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By V. Castranova, L. Wu, K. Van Dyke, J. Gutierrez, V. Vallayathan

Since it has been demonstrated that silica caused phagocytic cells to activate lipoxygenase metabolism of unsaturated fatty acids we thought selective inhibition of this metabolic pathway might be helpful in treatment of silicosis. It is known that lipoxygenase metabolism plays a role in the pathogenesis of a variety of inflammatory and hypersensitivity conditions. Further, it is believed that the alveolar phagocytic cells which engulf silica begin the inflammatory cycle which produces the metabolic products, cytokines and growth factors which causes fibrosis in the lung. There have been indications that drugs which inhibit lipoxygenase can inhibit fibrosis from other causes. Previously, we developed a method which detects the activity of lipoxygenase metabolism by measuring free radical oxidation via light production or chemiluminescence (CL). We decided to apply this method to phagocytic cells that would be found in the lung in the presence of silica with and without newly developed inhibitors of the lipoxygenase reaction. We used drugs which inhibit lipoxygenase directly including AA861 (TAKEDA), A63162 (Abbott), and an inhibitor that scavenges free radicals produced from the lipoxygenase reaction, nordihydroguairetic acid. In addition we used an indirect inhibitor, tetrandrine. We found drug inhibition of silica activated CL from alveolar macrophages, neutrophils and human leukemia (HL-60) cells differentiated with DMSO. Nordihydroguairetic acid 2x10-5M produced almost complete inhibition in all three cell types. In human leukemia cells (HL-60) A63162 and tetrandrine were equally inhibitory at 42% while in human neutrophils A63162 and tetrandrine were less active 22 and 10% respectively. In macrophages A63162 and AA861 were less than 50% inhibitory to cellular CL at 2xl0-5M. Direct assay of tetrandrine (2x10-5M) with sodium arachidonate and soybean lipoxygenase reveals no inhibition. All antilipoxygenase drugs regardless of mechanism were inhibitory to cellular chemiluminescence from all three types of phagocytic cells. These drugs alone or in mixtures could prove useful in treatment of silicosis.

Jan 1, 1991

Ferric (Fe3+) ions are omnipresent in flotation circuits. Depending on pH and the nature of the ore body, Fe3+ ions may play a role in the adsorption of thiol collectors on sulfide minerals. To investigate this possibility, a two-compartment galvanic coupling cell was designed. This cell was used to monitor changes in contact angle of a sulfide mineral in one compartment, while varying concentrations of the Fe3+ ions in the other. The results showed that Fe3+ ions promote xanthate adsorption as indicated by the increase in contact angle. Implications of this finding in sulfide mineral flotation in general will be discussed.

Jan 1, 1998

By James M. Krese

The West Kentucky Division of Island Creek Coal Company, which is a wholly owned subsidiary of Occidental Petroleum Corporation, operates the new Hamilton Mine. It is located six miles West of Morganfield, Kentucky, in the Northwest section of Union County, adjacent to the Ohio River in Lock 50. On July 15, 1968, a unique new coal conveying system was put in operation. This system consists of eight conveyor units carrying coal from the bottom of the mine slope ultimately to barges on the Ohio River. It is over two miles in length and has a total of 3175 connected horsepower. The river loading conveyor is the longest 72" wide conveyor in operation in this country.

Jan 1, 1969

By H. E. Rojas

The primary objective of most comminution operations is liberation; however, mill performance is generally quantified in terms of particle size. Only recently has the use of image analysis equipment made it possible to quantify mill performance on the basis of liberation. In this investigation, a series of tests were carried out to study the effect of mill operating parameters on the liberation of sphalerite from a sphalerite/dolomite ore. The parameters studied included mill rotational speed, mill loading and ball size. The results of this work appear to indicate that sphalerite liberation is improved under conditions that promote impact breakage, while dolomite breakage is enhanced under attrition conditions.

Jan 1, 1990

By Y. J. Wang

The Hardy Cross iterative method is the most popular technique for solving a ventilation network problem with natural air splitting. This method traditionally solves each mesh equation by an approximation during each iteration. Thus, it is interesting from both a theoretical and a computational viewpoint to be able to solve for an exact solution to the mesh equation. Presented in this paper is an algorithm for computing the exact solution to the mesh equation with a variable fan pressure. The algorithm uses signum functions for air quantities to generate an alternative mesh equation in the form of a quadratic equation that has two solutions defined by the well-known quadratic formula. The condition that the derivatives of the alternative and the original equations must be the same provides a basis for the correct choice between the solutions.

Jan 1, 1998

By Rudolf E. Pfister

One of the Swiss transalpine highways includes two remarkable tunnels: the 16.3 km long Gotthard Road Tunnel and the 9.3 km long twin tube Seelisberg Tunnel, both presently under construction. Large diameter shafts up to 900 m long are required for ventilation. Excavation techniques for rock formations ranging from loose sedimentary rock to granite and very hard siliceous limestone were carefully evaluated. The methods finally applied include excavation of shafts in hard rock, conventional drilling and blasting, excavation by ripper-tooth excavator ("Big John") in marlstone, shield protected heading in loose material and soft rock, and tunnel and shaft lining, both by poured concrete and by prefabricated elements. A critical review of the success of these methods can now be made after a five year construction period.

Jan 1, 1976

Reaction kinetics for gold dissolution in acid thiourea solutions were investigated using formamidine disulfide as an oxidant. For the conditions studied it appears that a surface reaction limits the rate of gold dissolution. The rate was found to be first order with respect to thiourea concentration and half order with respect to the concentration of formamidine disulfide; the apparent activation energy for the reaction was 10.40 kcal/mol (43.40 kJ/mol); and the reaction rate was independent of pH for the pH range 1.0 to 3.0.

Jan 1, 1999

By Irwan Halim, Stephane Polycarpe, Brian Hann

The Narragansett Bay Commission Phase III CSO Program includes construction of the 11,600-foot long, 30-foot ID, deep rock Pawtucket Tunnel in Rhode Island. This paper provides an overview of the Design Build Project features and highlight some of the important design considerations, features, and innovations, including geologic conditions and related TBM design, and deep shaft and tunnel segment designs. The paper provides the most recent updates on some of the project construction activities including TBM tunnel progress and retrieval schemes, tunnel pump station and deep vertical shaft liner installations, SEM construction, and microtunneling for the longest adit using Fiberglass Reinforced Polymer Mortar pipes.

Jun 23, 2024

By W. W. Wen

Approximately 3 percent of the raw coal processed in U. S. Steel coal-preparation plants ultimately reports to slurry- tailing disposal. The usual disposal method is to pump the refuse slurry containing the minus-48 mesh (300 µm) refuse into dams or impoundments that are constructed of the coarse refuse. The failure of an impoundment at Buffalo Creek, Saunders, West Virginia and the sliding failure of a coarse refuse pile at Aberfan, Wales, England, resulted in an evaluation of refuse disposal methods by various regulatory agencies as well as coal producers. The result of this evaluation was the promulgation of Federal regulations dealing with the construction, operation, and final abandonment of coal refuse disposal areas. As a consequence of these regulations the use of the landfill/impoundment method of disposal became in some cases economically urlfeasible or technically impossible. U, S. Steel has studied a number of alternative methods of refuse disposal. During an investigation of mechanical dewatering with a pressure filter, Portland cement was added to the slurry to solidify the filter cake. Because of the success of the cement addition it was decided to study the stabilization of fine-coal-refuse slurry through use of cement-type additives.

Jan 1, 1979

By Alan G. Fricker

Cyprus Gold NZ Ltd will be recovering residual free cyanide in barren gold pulp by air stripping. Laboratory investigations by DSIR have indicated additional advantages by recovering the cyanide from pregnant pulp. These are a lower leach pH, a greater cyanide recovery and less carbon consumption. They have a net economic advantage of $1.20/tonne over recovery from barren pulp. The realisation of these advantages is dependent on three crucial technical aspects -optimum pH for dissolution, the absolute loss of cyanide and the stability of the aurocyanide ion. The laboratory investigations described herein address these aspects. Earlier work had indicated that the rate of dissolution of freely revolving gold discs at constant cyanide ion concentration increased with decreasing pH from 11 to 8. Attempts to repeat the work in a more controlled manner by measuring the corrosion potential and current density have, to date, not been reproducible, but do not contradict the earlier observations. Cyanide recoveries and balances were obtained on leaches at pH 10.5 and 9 at the same cyanide ion concentration -the lower pH requiring three times as much total cyanide. Unaccounted-for losses, unfortunately, exceed the accounted-for losses, making interpretation of the balances difficult. Nevertheless, it appears that the additional amount of cyanide at the lower pH of 9 may not be fully recoverable. It may not, however, prove necessary in practice to use more cyanide at a lower pH. Both the gold and silver cyanide complexes remain available for carbon adsorption, as do mercury, copper and iron. Zinc, and probably cadmium, nickel and lead, may precipitate during stripping, which is an environmental advantage.

Jan 1, 1991

By S. S. Klima, A. L. Mazzella, J. S. Driscoll, T. W. Beck

Previous testing was performed by researchers at the National Institute for Occupational Safety and Health (NIOSH) to improve longwall dust control using underside shield sprays with a longwall directional spray system. This testing provided encouraging results toward respirable dust exposure reductions for longwall personnel, achieving as high as 99% dust reduction at some sampling locations along the longwall personnel walkway. Additional laboratory testing was conducted to test these underside shield sprays in conjunction with a shearer-clearer spray system located on the longwall shearer body. The purpose of this testing was to determine if the underside shield sprays interacted positively or negatively with the shearerclearer sprays. Results from this testing indicate that while the shearerclearer system influences where the respirable dust particles are directed, underside shield sprays can still lower respirable dust exposure for longwall personnel.

Mar 2, 2022

By Michael R. Grubbs

In most resource recovery plants the incoming solid waste material is first shredded and then air classified into a light and a heavy fraction. The light fraction which contains mostly paper, cardboard, etc., can be used either as a fuel for power generation or in the production of new paper products. The heavy fraction which remains consists mostly of glass, ceramics, wood, ferrous metals and non-ferrous metals. The ferrous metals may be removed from the heavy fraction by conventional magnetic separators. After primary shredding, most of the glass and ceramic is fine in size and may be screened away leaving a residue of wood, cardboard, and non-ferrous metals. This residual heavy fraction is the input material for the separator described in the present paper. A new metal separator was recently reported by t. Schlömann1. The author described the theoretical relationships and presented results of tests on samples of the residual fraction of municipal solid waste. This paper describes the operation of the metal separator and develops the basic separation relationships controlling the process.

Jan 1, 1976

By J. Peterson, P. G. McKneight, R. W. Riggle

"In today’s tough mining environment, the key difference between surviving and thriving is how effectively miners optimize their mining operations. This paper explores the compounding effects material fragmentation has on mining costs and productivity. Starting with Drilling & Blasting and moving through Loading, Hauling and Crushing, we will illustrate the opportunities to improve operating costs and thus reduce the Total Cost of Ownership (TCO) of the total mining system. Material size and volume requirements are defined by the needs of the mill or plant, and drive the rest of the mining operation from the bench through the primary crusher. At the start of the cycle, where the rock mass is drilled and blasted, the degree of fragmentation and the muck pile configuration is determined, as are the effects on cost and productivity of all subsequent operations. The cost of managing oversize material, including secondary handling, overloading, reduced diggability, higher load factors, extra pass loading, increased wear factors and reduced throughput rates are all opportunities for improvement. INTRODUCTION Having visited many mine sites, customers are asking about the end to end mining value stream from loading to the crusher and how to measure the cumulative effects on each part of the mining value chain. All too often improvements with the drilling and blasting may impact fragmentation but do not improve the diggability so the net change on cycle times or fill ratios is perceived to be negative at the point of loading but they may have a measured improvement going through the primary crusher. This makes it imperative to measure performance at each segment of the overall cycle and not just to the crusher but thru it. The mine material process originates with solid rock, in-situ, and progresses to the output of the primary crusher. Once the material has passed the primary crusher the fragmentation size will be fairly consistent and promote consistent throughput of the plant or mill. In late 2015 a team was conducting a reassessment visit to a mining site where we had conducted the original assessment the previous year. Though many recommendations had been implemented some had been so recent they had not resulted in the expected improvements. Several of our discussions kept returning to the impact fragmentation has to both the individual components of the mining cycle but also the effects compounded throughout the end to end process. Let’s move on to the big picture before we zoom in on any specific operation. To get from native solid rock in the ground to a concentrate or a saleable rock product we have the same steps from one end of the chain to the other. We start with a good geological understanding of the rock type, characteristics and structure to design a program to drill and blast the rock. The height of the bench is relevant to the annual production requirements and the specific digging equipment models best sized to make that production possible. The equipment selection influences the bench height which has a minimum and maximum hole diameter to maintain a safe blasting operation. The diameter of hole burden and spacing all contribute to a good distribution of explosives in the rock mass that maximize the fragmentation and preconditioning of the rock when blasted. The timing and sequencing of hole initiation will yield a fragmentation ratio and diggability factor. Fragmentation size adjustments will change the meters drilled per cube and the explosives consumption will change accordingly. Drill cost is measured by meter drilled so a direct relationship exists between cost and fragmentation sized achieved."

Jan 1, 2017

By K. W. Vincent

This paper, deals with the beneficiation of a low grade Western phosphate to ore. More specifically it summarizes the results of a study made to optimize a scrubbing step in the process, and to provide firmer data for use in plant design. The deposit is situated about 30 miles northeast of Pocatello, Idaho, in the Fort Hall Indian Reservation. It is a bedded deposit and throughout most o the orebody includes three contiguous layers of phosphatic material which differ in P205 content. The J. R. Simplot Company, as operator for a Simplot-FMC joint venture, mines the ore selectively by open pit methods The lower bed containing a nominal 30% P205 is shipped to the Simplot Company fertilizer complex near Pocatello; the middle layer averaging about 24% P205 supplies the FMC elemental phosphorus plant also near Pocatello, The top layer averaging around 16% P205 and designated as mill grade shale is stockpiled for future beneficiation. This paper is concerned with some aspects of the processing of this low grade shale.

Jan 1, 1965

By W. J. Adamson

Strategic Data Planning (SDP) is an emerging technique for the analysis and design of information systems. This paper describes the use of strategic data planning in the formulation of a complete integrated set of mining technical systems for the Koolan Island iron ore mine. Applications covered include hydrogeology, geology, mine planning, surveying, quality control, laboratory and mine production recording. Koolan Island is 13 kilometres long and 5.5 kilometres wide at its widest point. Its sole industry is an open pit iron ore mine of 3 million tonnes annual capacity, owned and operated by BHP Minerals. Some of the production is used by BHP Steel International, but most is exported. The orebody is steeply dipping and is mined bench by bench. Outturn grades for run-of-mine product are iron 66.5%, silica 3.0%, alumina 1.0%. Computer systems are run on Data General equipment, currently an MV10000. Computer applications, which are shared across mine sites, are developed and maintained by BHP Information Systems in BHP's Melbourne Office.

Jan 1, 1986

By Paul Madsen, Bade Sozer, Thomas Hennings, Eileen Test

The Rondout Bypass Tunnel in New York has two access shafts. The upper sections of the shafts are lined with steel pipe to resist a substantial net internal water head . Initial design included a ¾-inch-thick cement mortar lining (CML) for all three components. Because of concerns with CML application on large-diameter pipes, the protective lining was redesigned for shotcrete application. This paper discusses the details of that design, mock-ups, and shotcrete application.

Jun 13, 2023

By J. A. Jirestig

Laboratory investigations on the possibility for magnetic separation of sulphide minerals are reported. A survey of several sulphide ores and flotation concentrates shows that magnetic separation in most cases is not a suitable primary method of beneficiation. However encouraging results have been obtained in concentrate purification. At the Boliden complex sulphide ore concentrator in Garpenberg a Allis-SALA MK III carousel High Gradient Magnetic Separator (HGMS) is used together with a small flotation circuit to recover sphalerite lost to the galena concentrate in lead flotation. The result after four years of refining the HGMS process, show increasing zinc recovery and enhanced quality of the lead concentrate.

Jan 1, 1993

By J. P. Golightly

The structure and occurrence of nickeliferous laterite profiles are described and explained in terms of mineral solubility and drainage conditions. Complete profiles, from top to bottom, include: limonite zone; nontronite or silica zone; and saprolite zone. The middle zone is present only where drainage is sufficiently slow to allow saturation conditions to build up with resulting quartz or smectite precipitation. This precipitation may occur in any climate at a water table or in tropical climates with a long dry season. The degree of serpentinization of the laterite parent rock is important in determining the nature of the saprolite zone. Unserpentinized peridotite produces saprolite ores with hard residual rock cores, nontronitic or amorphous saprolitic rims, and fracture fillings of garnierite and quartz. Ser-pentinites yield relatively homogeneous serpentine saprolite, with minimal quartz or garnierite.

Jan 1, 1979

By R. R. Klimpel

This paper describes four new families of flotation products which are currently being introduced at the industrial level. A brief summary of the chemical basis behind each product family will be given. This is then followed by a selection of flotation examples which illustrate the more important use characteristics that have been observed to date. It is becoming more apparent with further testing that these four new product families can offer both technical and economic advantages to the industrial flotation process operator.

Jan 1, 1992

By X. Xie

The dissolution behavior of palladium powder in thiourea solutions has been studied. The variables studied included temperature, stirring speed, and concentrations of thiourea, acid and ferric ion. Palladium was found to be soluble in thiourea solutions in the presence of an oxidant such as ferric ion. The dissolution of palladium in thiourea solutions was found to be chemical reaction controlled with an apparent activation energy of about 2S.3 kJ/mol.

Jan 1, 1995