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By T Krull, T J. Donohue, D Ilic

"Problematic issues in materials handling applications are often amplified in the iron ore industry due to the relatively high density of the ore as well as the abrasive nature of the product. One of the main issues arising from the handling of iron ore is excessive wear, with two applications typically suffering accelerated wear issues being transfer chutes and conveyor belts. These wear issues are problematic due to additional capital costs, but mainly due to the associated downtimes resulting in the accelerated wear. This study will focus on the modelling of iron ore in practical applications where design work was undertaken in order to reduce the wear rates of different materials handling equipment.CITATION:Donohue, T J, Ilic, D and Krull, T, 2013. Modelling of iron ore in materials handling applications with a focus on wear, in Proceedings Iron Ore 2013, pp 355-362 (The Australasian Institute of Mining and Metallurgy: Melbourne)."

Aug 12, 2013

By P Dowd, A Adeli, C Xu, X Emery

Geometallurgical modelling is increasingly being incorporated into mineral resource modelling and estimation as a means of increasing efficiency, decreasing operating costs and reducing risk in mining operations. Traditional geostatistical workflows for geometallurgical modelling face several difficulties, in particular, related to the non-additivity of process response variables, to highly heterotopic data sets and/or to preferential sampling designs, all of which may explain why most attempts to estimate geometallurgical response variables from assay data and mineralogy are still based on statistics and machine learning. The aim of the work presented here is to demonstrate the applicability of geostatistics to estimate copper recovery from copper sulfide ores at the Prominent Hill Iron Oxide Copper-Gold (IOCG) deposit in Australia. As recovery is non-additive, the preferred workflow is the joint estimation of the masses of metal in the feed and in the concentrate, both of which are additive variables. While the mass of metal in the feed can be estimated from abundant online assay analyses, the mass of metal in the concentrate can only be estimated from a very limited number of laboratory-scale batch flotation tests. Traditional approaches to estimating the masses of metal in the feed and in the concentrate, such as simple and ordinary co-kriging, are described and discussed. A modified version of co-kriging is introduced, which incorporates linear relationships between the mean values of the input variables, in addition to a spatial correlation model. Co-kriging with related means is shown to outperform traditional simple and ordinary co-kriging in terms of precision, accuracy and consistency of the estimates, and offers a practical and efficient tool to deal with highly heterotopic and preferential sampling designs.

May 24, 2023

Risk management for resources and reserves includes examining the fundamental processes of data collection, interpretation, modelling and estimation. Newmont Australia has developed a procedures manual to assist mine sites to build Resource block models, estimate Ore Reserves, validate the outcome and report the results. An audit scheme has been developed to compliment the procedures manual by assessing the degree of site compliance with recommended practice. A score of between one and five stars is awarded to each site depending on its performance in the audit. Audits are undertaken by a team of three Newmont personnel over a three to five day period at each site. Scores are ultimately compared between sites and reviewed annually. The objective of the program is to encourage continuous improvement in the modelling, estimation, validation and reporting practices used at sites and in advanced projects. The scheme provides a method of risk management for the companyÆs biggest asset û its Ore Reserves. Newmont Mining Corporation is preparing to use the audit scheme internationally in part to conform with recent legislation requiring US companies to demonstrate that management systems and procedures are in place to monitor and verify the companyÆs assets.

Jan 1, 2003

The emerging discipline of ægeometallurgyÆ is not new but is becoming increasingly recognised as a discrete and high-value activity that reflects an ongoing commercial and cultural trend towards more effective mine site integration and optimisation. The AMIRA International P843 æGeMIIIÆ project (Geometallurgical Mapping and Mine Modelling) is a major new cross discipline research collaboration designed to provide support for this emerging industry trend. The project is currently supported by 18 global mineral companies and involves collaboration between the CODES Centre of Excellence (University of Tasmania), JKMRC and BRC (University of Queensland) and CSIRO Exploration and Mining. These groups represent recognised research excellence in the fields of economic geology, automated core logging, advanced microscopy and process mineralogy, mineral processing, mine planning and resource optimisation. The needs and challenges of geometallurgy as an integrated activity will be outlined together with the ongoing contribution and aims of the AMIRA P843 æGeMIIIÆ project. The main emphasis is on development of predictive geometallurgical indices for key processing performance parameters that reflect inherent geological variability. The ultimate aim is to provide predictive indices of geometallurgical performance that can be confidently embedded into resource models and used for risk-defined mine planning and optimisation.

Jan 1, 2008

The Mineral Resources Act 1989 was assented to on 25th October, 1989 after more than two years of consultation and negotiation between Government, the mining industry and other affected parties particularly the major rural organisations.The legislation proposes major conceptual changes in a number of areas and adopts a totally new approach to the definition of land and the mechanisms available to the mining industry for accessing such land.Unfortunately the passage of the legislation through Parliament coincided with the lead-up to the State election. Ultimately it became an election issue generating much adverse comment in the media particularly from rural and landholder groups. It was obvious that much of this anti-mining propaganda resulted from a lack of understanding of the legislation and the benefits that flow to the majority of landholders as well as the mining industry.It is essential that the contents of the Mineral Resources Act be thoroughly understood by all parties. Only then will all the State's resources be able to be developed in a multiple land use environment.This paper outlines the philosophy behind the new Act and the more important provisions contained therein.

Jan 1, 1990

A considerable debate has arisen regarding the best route for the beneficiation of iron ore. Supporters of jigging technology claim that although the technology is old, due to recent advances in jig control and a better understanding of the separation processes within jigs, it offers significant advantages over dense medium separation, especially in terms of reduced capital and operating costs and simplicity of design. Supporters of dense medium separation claim that this technology is proven to provide the best possible separation and that the gain in efficiency over the life of the plant, compared to that of a jig, will more than offset any differences in capital or operating costs. The truth is that both viewpoints are valid and that the choice is ultimately determined by specific characteristics of the ore being treated. Factors that need to be taken into account in deciding upon the correct option include the size/density distribution of the ore to be treated, the different size fractions which must be treated (lumpy or fines), differences in yield at grade, plant layout and capital and operating costs. Each of these factors will be discussed in detail and a case study for both lumpy and fines will be presented.

Jan 1, 2007

By M English, M Yumlu

At times of high metal prices, mining projects that have previously been put into the ætoo hard basketÆ are now being more closely examined. Typically these projects include the potential recovery of small mineable tonnes with high contained metal values and often with poor ground conditions. For many underground mining projects, the drift and fill method is viewed as a high-cost method and a æmethod of last resortÆ. As a result the method is not well known in Australia and it is the authorsÆ view that the method is under utilised. The drift and fill method can be applied to a variety of underground mining situations and is a preferred method for some orebody geometries and where ore recovery is viewed as a key to project success. This paper examines some of the critical mine planning and backfill issues involved with the drift and fill mining method.

Jan 1, 2008

Dartbrook (Hunter Valley and South Bulli (Southern Coalfield) Collieries provide contrasting settings for gas sorption studies. Gas compositions at Dartbrook are dominated by carbon dioxide, with minor methane, while those at South Bulli are dominated by methane with minor carbon dioxide. Total gas contents at Dartbrook are also significantly greater than those at South Bulli. The two collieries are also contrasted in terms of coal composition and mining environment. Dartbrook Colliery mines a relatively small sectionb(4m) of very thick seam (up to mapproximately25m); the coal is vitrinite-rich, high volatile bituminous. South Bulli mines most of the seam thickness, with coal being an intertinite-rich, medium volatile bituminous coal.Coal samples have been collected from in-seam gas drainage holes for evaluation of relative gas desorption rate (methane versus carbon dioxide). Following adsorption isotherms, petrography, chemistry (proximate and ultimate analysis) and pore structure analysis (carbon dioxide surface area, mercury porosimetry). Bomb desorption studies indicate different behaviours for methane desorption at these two collieries desorbed gas compositions at South Bulli show a small enrichment in methane content. The opposite is observed at Dartbrook. Both collieries show enrichment in CO2 in the residual content. Adsorption studies show marked variation in adsorbed gas contents for methane and carbon dioxide at each colliery and between collieries. These variations are related to differences in coal pore structure, chemistry and Petrology.

Jan 1, 1998

By P Holtham, W Valery, P Baguley, A Jankovic

There is a growing interest in magnetite ores because of the increasing demand for this commodity. With these ores, there is significant cost associated with milling the ore to fine sizes using ball mills in closed circuit with hydrocyclones. Cyclone classification efficiency tends to be poor due to the large difference in density between magnetite and gangue. This decreases the grinding circuit efficiency and results in over-grinding of magnetite. The objective of the work described in this paper was to modify the Bond locked cycle milling test procedure to quantify the loss of grinding circuit efficiency due to the mineral density effect. The locked cycle test procedure described here includes a stage of magnetic separation treating the closing screen undersize, which allows simulation of magnetite classification. The effect of classifier efficiency on low-density particles (non-magnetics) was simulated by altering the proportion of closing screen undersize bypass returning to the mill. Using a magnetic separator and a screen in the magnetics stream, different proportions of the magnetic fraction can be bypassed, thus allowing simulation of the effect of particle density on classification efficiency. This laboratory test work has confirmed that the impact of mineral density on cyclone efficiency subsequently has a crucial negative effect on ball mill circuit capacity. The results are in good agreement with reductions in capacity observed in practice. Multicomponent grinding and classification models were also developed in the LIMN software environment and were able to successfully simulate both the industrial and the laboratory ball mill circuit. The test and modelling procedures established in this project could be used for improved design of new magnetite ball mill grinding circuits as well as the optimisation of existing circuits.CITATION:Jankovic, A, Baguley, P, Valery, W and Holtham, P, 2015. Effect of mineral density for milling magnetite ores, in Proceedings Iron Ore 2015, pp 159–164 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Jul 13, 2015

By R Willis, D Cooke, G J. Davidson

Mine-groundwater interaction at the Pasminco Rosebery Mine (PRM), western Tasmania, deserves special attention due to the unique climate and mining environment present. High rainfall and low evapotranspiration result in an excess of water, an uncommon problem at Australian sulfide bearing mines. Research is being undertaken to delineate current subsurface fluid flows and predict future fluid flows in order to improve management after mine closure. Acid mine drainage generation is well developed in abandoned mines throughout the area. If acid mine drainage is not controlled after mine closure, significant environmental degradation could occur in the receiving waters of the Pieman River system. The study area encompasses the heavily forested Mount Black, and underlying PRM workings. Groundwater flows beneath Mount Black through a crystalline fractured rock aquifer with faults and underground mine workings observed to act as the major hydraulic conduits. Recharge is controlled by local precipitation, and the ultimate discharge is thought to be the Pieman River system, which forms the topographic low in the area. Slug tests have been used in conjunction with the mineÆs extensive geotechnical database to spatially evaluate variation in hydraulic conductivity. In fractured rock terrain associated with mining, rock quality designation data can be a useful tool in delineating areas of similar hydraulic conductivity when combined with conventional hydrogeological methods. A GIS, mine planning software, an environmental and a geological database are linked to form the input for groundwater modelling.

Jan 1, 2003

By F P. van der Meer, E Lessing, E Matthies

High pressure grinding rolls (HPGR) technology is growing to be a common comminution tool in iron ore processing. The technology finds a wide acceptance and presents specific benefits in coarse ore grinding and closed-circuit grinding in preparation of ball mill feed, right down to the other end of the particle size spectrum for iron ore pellet feed preparation.A growing number of minerals processing plants are facing higher operating costs and difficulties due to a scarcity of process water, which in some cases is a result of more stringent environmental constraints. In addition, many new iron ore deposits are located in more arid regions of the world. These challenges have led to operators taking a new look at dry processing of iron ores.The use of dry crushing and classification technology in cement production from blast furnace slag, clinker material or limestone feed stocks indicates that the technology may be applied in minerals processing. In addition, dry processing provides the possibility of generating a final product from finely disseminated and inter-grown ores at sizes near or well below 100 µm, as may be required for beneficiation techniques such as in fine magnetic separation, flotation or magnetic flocculation.Dry grinding by HPGR has a number of specific features, challenges and opportunities, including balancing power input, moisture content requirements and classification efficiency in the process design. HPGR parameters and the latest HPGR design and sizing capabilities indicate considerable potential benefits from this dry processing technology.This paper highlights some of the specific issues that play a role in dry HPGR application, with respect to energy and materials balances. Examples of dry HPGR practices and process studies in iron ore mineral processing are discussed.CITATION:van der Meer, F P, Lessing, E and Matthies, E, 2015. Iron ore final grinding by high pressure grinding rolls and air classification, in Proceedings Iron Ore 2015, pp 197–204 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Jul 13, 2015

By Wilkinson LR

The object of this paper is to present a brief overview of applications of radioisotopes in mineral processing. The emphasis is towards on-line applications, and is to present the broad picture rather than become involved in the details of particular applications. For a more detailed and comprehensive coverage, the reader is referred to the International Atomic Energy Agency International Symposium on Nuclear Techniques in Exploration, Extraction and Pro- cessing of Mineral Resources, held in Vienna 7-11 March, 1977. Because of space limitations here, we have inmost cases restricted coverage to those applications of radioisotopes within the direct experience of Amdel and Australian research bodies. Radioisotopes spontaneously emit energy in tiie Form of a and S particles, and electromag- netic radiation. The electromagnetic radiation is generally referred to as y-radiation when it originates from the nucleus, and X-radiation when originating from the electrons orbiting the nucleus. X-ray and y-ray energies overlap, with X-rays extending from a few electron volts (%') up to about 100 keV. Gamma rays in the useful energy range extend from a few keV up to .feV.

Jan 1, 1978

By A Batnasan, K Haga, A Shibayama, K Higuchi, H Takeuchi

High silica (SiO2), alumina (Al2O3), and phosphorus (P) contents in iron ore adversely affect the quality of iron products. The removal of those impurities from iron ore is an essential point in further iron ore processing. In this paper, the removal of P, SiO2 and Al2O3 impurities from iron ore by alkaline drying followed by reverse cationic flotation is discussed. The reverse cationic flotation experiments are performed using the iron ore samples without and with alkaline drying pretreatment. All other flotation conditions except pulp pH (4–12) and particle size distributions (-45 to -250 μm) are held constant. A typical collector and frother, such as dodecylamine acetate (DAA) and methylisobutylcarbinol (MIBC), are used in the flotation experiments. Alkaline treatment is conducted before flotation using sodium hydroxide at fixed conditions. The impact of alkaline drying on the performance of iron ore flotation is evaluated based on the removal rates of P and SiO2 + Al2O3, iron grade, and iron recovery compared with the iron ore flotation without alkaline drying (direct flotation). X-ray diffraction (XRD) analysis indicates hematite and goethite are the main minerals in the iron ore, which assays 62.8 mass per cent Fe, 0.232 mass per cent P, 7.1 mass per cent SiO2 + Al2O3 (total) determined by X-ray fluorescence analysis (XRF). Results indicate that a combined approach is more effective for removing P and SiO2 + Al2O3 impurities from iron ore than the direct processing technique because the maximum removal rates of P and SiO2 + Al2O3 are 48.2 per cent and 66.5 per cent from the alkaline dried iron ore when 8.4 per cent and 13.1 per cent from the non-alkaline dried iron ore.

Sep 18, 2023

By C Artica

Two quantitative methods for Mineral Resource classification have been applied to a copper skarn deposit beneath a large open pit that is mining a world-class porphyry complex. A drill hole spacing study (DHSS) using the single block kriging method (SBK) and a conditional simulation method (CS) were applied to the skarn deposit and the results compared. Inputs to both processes included the proposed mining rate and stope designs to estimate the likelihood of achieving grade and metal production targets. Mineral Resource classification of the deposit considers the relative precision of tons, grade and metal predictions over quarterly and annual production periods. These relative precision estimates are calculated at 90 per cent confidence interval (CI). The SBK method represented the production period as a single large block. Kriging estimates were performed in the large block for various synthetic drill hole grids, and the estimation errors derived. The error was assumed to be normally distributed due to the large block size and quantity of samples, allowing CIs to be deduced. The CS method followed a conventional sequential Gaussian simulation workflow where grades were simulated with a 5 ft × 5 ft × 5 ft grid node spacing inside mineralisation domains. Each realisation was then averaged up to monthly production volumes represented by a combination of designed stopes, and the coefficient of variation (CV) for the averaged grade was calculated. CI on the relative precision of grade predictions were then deduced from the CVs. The two methods produced similar results; despite being calculated independently. CS results were used to report uncertainty in the proposed life-of-mine plan and highlight areas for additional drilling. SBK results were used as the basis for Mineral Resource classification as this method has been previously applied to the skarn deposit.

May 24, 2023

By F Baars, M Zu, C A. RosiFre, L Lobato

A genetic model for the genesis of high-grade (>65 wt per cent Fe) Proterozoic, banded iron formation (BIF)-related iron deposits such as the Tom Price, Mount Whaleback deposits in the Hamersley Province (Australia), the N4E, N4W, N5 deposits at Carajßs (Brazil), the Aguas Claras, Conceitpo, and Casa de Pedra deposits in the Iron Quadrangle (Brazil), the Donkerpoort West, Kwagas East deposit in the Thabazimbi iron ore district (South Africa), or the Saksagan ore field at Krivoy Rog (Ukraine), needs to take into account the: timing of regional metamorphism with respect to the upgrade of BIF to high-grade iron ore; significance and relationship of the proto-ore to the hydrothermal alteration minerals and zonation and the process of iron enrichment; source and oxidation state of the hydrothermal fluids that caused the iron enrichment; types of geochemical processes that caused the hydrothermal alteration and iron enrichment; and significance of the widespread carbonatisation of the host rocks as a prerequisite for high-grade BIF-related iron mineralisation.We argue that a unifying model for high-grade BIF-related iron deposits cannot, presently, adequately explain the geological and geochemical characteristics observed in these deposits and, therefore, provide two end-member models that take into account the diversity of geological and geochemical ore deposit features. Our discrete model for the genesis of high-grade, BIF-related iron deposits is based on the interpreted tectonic setting, distinct hydrothermal fluid source of, and processes observed in, major BIF-related iron deposits. We divide two end-members: Proterozoic deep fault-magmatic (Carajßs) type, and Proterozoic rift-basin (Hamersley) type.Both end-members experienced varying degrees of deep weathering episodes that effected the hypogene enrichment and, ultimately, yielded the high-grade iron ore mined in many places today.

Jan 1, 2005

The purpose of this paper is to explain the basic structure of how minerals are marketed, whilst highlighting the essential factors that mine management needs to be confident are incorporated into a mineÆs marketing strategy. The traditional mine management approach to marketing has been to defer its scrutiny to the marketing manager and take a largely passive role. It is this paperÆs assertion that mine management needs to become more proactive and provide greater strategic input into the marketing process. Irrespective of what mineral your mine produces, the key marketing principles remain constant and need to be understood and managed to extract the full benefit on behalf of the mining asset. From a mine management perspective, success is ultimately linked to understanding these marketing principles and ensuring that they are effectively addressed by your mineÆs marketing strategy. This paper will unashamedly attempt to simplify marketing by explaining how the basic fundamentals of supply and demand set market direction, the importance of a comprehensive marketing strategy, the importance of customer relationships and how contracts and prices are typically negotiated. This paper will use examples from the metallurgical coal (met coal) industry to highlight these points. The paper will also provide a template for developing the critical mine interaction that needs to exist between the marketing department and management to develop a æwhole of mineÆ approach to marketing. It is this core group that will be strategically responsible for delivering the commitments your mine has made to your customers. For mine management not to be actively involved in this process puts at æriskÆ the hard won production and cost efficiencies achieved at your mine and ignores the opportunity to maximise your current and future revenue streams. And whilst this paper recognises that is arguably unreasonable for mine management to become æmarketing expertsÆ, it also argues that it is unreasonable for a mine management to divorce themselves from the process.

Jan 1, 2006

By J-P Franzidis, M Esvelt, E V. Manla

The Floatability Characterisation Test Rig (FCTR) is a self-contained, highly instrumented, mobile pilot plant that is able to treat up to 2 tph solids. It consists of a bank of six 130 L WEMCO« SmartCells« and a bank of six 50 L WEMCO« SmartCells«. It was developed as part of the AMIRA P9 Project, primarily to determine ore floatability characteristics and to develop and validate flotation plant modelling, scale-up and simulation methodologies. However, it may also be used to carry out pilot-scale flotation test work. This paper briefly describes the circuit modelling, simulation and scale-up test work performed using the FCTR and the use of the FCTR in pilot-plant test work performed by the metallurgical staff at WMCÆs Kambalda Nickel Operations and Mount Keith Nickel Operation. At both Kambalda and Mount Keith the FCTR was found to be very flexible and straightforward to run, with an easily changeable circuit configuration and stable operation. Testwork was facilitated through having full stream sampling on all streams, and a high degree of instrumentation providing accurate measurement of process variables. The results obtained from the FCTR testwork were highly repeatable. As a consequence of using the FCTR, WMCÆs Kambalda Operation and Mt Keith Operation were able to complete a rigorous programme of pilot plant testwork more quickly than in the past, and with a high degree of confidence in the results.

Jan 1, 2003

By O Handayani, R Barr, E Isaaks

The mining industry has focused a great deal of attention recently on the impact of blast movement on grade control. Although the problem of blast movement and its contribution to dilution and ore loss is well known, solutions to the problem are less than satisfactory. Perhaps the most recent innovation is the application of blast movement monitoring (BMM) devices to quantify blast movement. These devices emit an electronic signal and are planted at surveyed locations within the preblast material. Following the blast, their new locations are found using an electronic scanner. The magnitude and direction of the blast movement is given by the vectors between the pre- and post-blast BMM locations. However, it’s not clear how the BMM vector data can be best used to minimise dilution and ore loss. One common solution is to displace preblast dig line polygons by distances indicated by the BMM vectors. However, studies of BMM vectors show that blast movement not only displaces material laterally but also mixes material internally within the bench (Thornton, 2009a).This paper presents a method for modelling the post-blast muck pile that accounts for displacement and internal dilution using simulated annealing. The preblast ore control block model is re-blocked to 1?×?1?×?1?m sub-blocks. Each sub-block is displaced by simulated BMM vectors conditional to post-blast surface topography and blast initiation sequence data in addition to BMM vector data. The displaced sub-blocks are aggregated into new ore control model blocks whose grades are calculated from the contained sub-blocks. New dig lines are then designed on the post-blast muck pile model using the new ore control block model grades. A case study based on actual data is provided.CITATION:Isaaks, E, Barr, R and Handayani, O, 2014. Modelling blast movement for grade control, in Proceedings Ninth International Mining Geology Conference 2014 , pp 433–440 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Aug 18, 2014

By P Marlow

Raiseboring is an attractive method of constructing shafts, being safe, fast and comparatively cheap. But this means back-reaming through weathered ground. However in the gravels and weathered near-surface rocks typical of the Western Australian goldfields, back reaming large diameter shafts through to the surface is risky and conventional sinking from surface has normally been required.An alternative construction approach has recently been used to stabilise the weak surficial materials and allow raiseboring through to the surface. The method is based on first installing rings of non-contiguous reinforced bored piles around the shaft perimeter, for temporary support, then back reaming shafts at full diameter through to the surface. Immediately after the reaming head is removed, the weak exposed materials are supported using remotely sprayed fibrecrete.The method has been successfully applied to four shafts since July 2007; 3 m and 4 m diameter shafts at Trident Mine, a 3 m diameter shaft at Wattle Dam and a 4.5 m diameter shaft at Athena Mine.Bored pile layout designs have varied from eight to 24 piles, of diameters 120 to 270 mm, in one or two rings. In one case, the top 10 m of the proposed shaft was pregrouted. Subsequent surveys have confirmed that fallout occurred in some shafts, out to the ring of piles, implying that the piles inhibited collapse.The practical implementation of the method was not always easy and many valuable lessons have been learnt. This paper documents key aspects of the method and the critical elements for its application.

Mar 21, 2011

By R J. Romañach

The theory of sampling (TOS) is now followed in the development of near infrared (NIR) spectroscopic methods for the pharmaceutical industry. TOS has been the guiding light for a two-step approach for spectroscopic composite sampling available for the development of real-time analytical methods for particulate-based industrial processes. The two-step spectroscopic sample composite has been used in the development of process analytical technology (PAT), an important regulatory initiative to improve the quality of pharmaceutical products. The two-step sample composite approach overcomes the low sample volume analysed by PAT methods; one of the key limitations to PAT implementation in the industrial production of particulate-based materials.PAT methods need to be validated demonstrating their accuracy, precision, specificity and robustness. TOS provides a deeper understanding of these validation studies which involve discrete particulate material. The validation of PAT methods is now being performed considering both sampling and analytical errors, while practically all previous method validations only addressed the total analytical error (TAE) of these methods. This has been a crucial impediment for the field of chemometrics as well.PAT is a key element of continuous manufacturing (CM) processes, which are considered an emerging technology capable of increasing the flexibility, agility and robustness of pharmaceutical processes while reducing their costs. The outflow of the continuous process is a 1D lot, and variographic analysis has been shown to discern process variation from sampling and analytical errors in pharmaceutical CM processes. Thus, variographic analysis is a process improvement tool with significant potential for improving CM processes. The possibilities for improving pharmaceutical manufacturing are enormous.CITATION:Romañach, R J, 2017. Theory of Sampling – from missing link to key enabler for process analytical technology, in Proceedings Eighth World Conference on Sampling and Blending , pp 63–68 (The Australasian Institute of Mining and Metallurgy: Melbourne).

May 9, 2017