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By A. W. Khair, M. Ahmad, L. D. Gehl

"This paper presents an analysis of the dynamics of bit wear on the productivity of the continuous miners. Two field surveys have been carried out. The first survey was to assess the impact of bit wear on productivity and production cost. The second survey was to study the wear characteristics of the cutting tool (i.e. magnitude, forms, and mechanisms of bit wear). Primary factors affecting bit wear is identified and laboratory experiments were carried out to study the effects of some of these primary factors on wear in detail. Results indicate that bit wear has a significant effect on the productivity of the continuous miners. Furthermore under the severe geologic conditions (i.e. cutting rock partings and roof and floor rocks) bit wear not only hampers the productivity, but also increases the production cost due to a higher number of bit consumption. This study also indicated that bit wear accelerates beyond 20% of the conical height loss which corresponds to 7% of the weight loss. This increase rate of wear is an indicative of higher abrasion between bit body and cutting material, resulting in a more dusty environment.IntroductionThe high demand for coal production has increased the need for mechanized coal cutting in underground coal mines. Continuous miners have been used in the United States of America for nearly four decades and now presently more than 2000 are in operation. Almost half of the underground coal production of the country is by continuous miners. Today, competition in the coal industry has increased, due mainly to market conditions and legal restrictions, thus placing an emphasis on production, efficiency, and safety. The use of continuous miners has resulted in the generation of respirable coal dust which causes black lung in mine workers. On the other hand, bit wear presents a serious problem as it affects productivity and economy.Much research in the put has been done on energy requirements and mechanism of energy dissipation for ideal rock fragmentation in the cutting process. Recently, dust hazards in underground coal mines as a result of coal cutting has been a great concern to mining engineers as well as environmentalist of the country. In past, much emphasize has been given to fragmentation mechanics (Khair et al, 1989), dust generation due to regrinding (Khair and Xu, 1991) and dust generation due to bit wear (Khair, Xu. and Ahmad, 1992). These studies concluded that dust concentration increased considerably after a bit weight loss of 7% and thereafter the bit should be replaced. Thus, legal restriction by the Mine Health and Safety Administration for the respirable dust concentration in underground might be a factor deciding the level or rate of production using continuous miners. While efforts in research are on reducing dust generation, it is also important and relevant to study bit wear in more detail.Bit wear is affected by three major groups of parameters: (1) machine operating parameters, (2) insitu conditions and (3) properties of rock. Again, past studies have shown that depth of cut, material of tool, position of water jet and velocity of the rotating drum are very important machine operating parameters. The content of the rock/coal material is important as bit wear is usually due to abrasion or adhesion. Diffusive wear becomes dominant only when the temperature exceeds the sensitive range i.e critical temperature. Mechanical tools have indicated that a rise in temperature is a function of drum velocity, properties of cutting material (rock or coal) and properties of tool. Bit wear due to chemical reaction and oxidation art almost negligible in coal cutting."

Nov 1, 1995

By Maria I. De Rosa

Table 1 and figure 1 show the number of fires and fire in¬juries that occurred in underground coal mines by state during 1990-1999. Table 1 also shows by state the risk rates, employ¬ees' working hours, lost workdays, and coal production. Over¬all, 87 fires occurred in 12 states. Twenty-seven of those fires caused 34 injuries (the yearly average was 8.7 fires and 3.4 injuries). One fire and one injury involved a contractor. The underground mine fires required 25 mine rescue team interventions and 30 mine/section evacuations followed by 13 mine/section sealing/flooding/CO2/N2, gas injections. The Ewhr value was 1,003 x 106 hr (In = 0.007), the CP value was 4,008 x 106 st (Frr = 0.022), and the LWD value was 208. Virginia had the most fires (15 fires and 7 injuries). Pennsyl¬vania had the most fire injuries (12 fires and 9 injuries), fol¬lowed by Kentucky (12 fires and 6 injuries), and Alabama (12 fires and 4 injuries). Among these states, Alabama had the highest fire risk rate value (Frr = 0.073), whereas Pennsylvania had the highest injury risk rate value (In = 0.016). Table 2, partly illustrated in figure 2, shows by time period the number of fires, fire injuries, risk rates, employees' working hours, lost workdays, and coal production. The number of fires and fire injuries show a decrease followed by an increase during the five time periods (see table 2 and figure 2). This was ac¬companied by a decline in employees' working hours throughout the periods and an overall small decrease in coal production. The In and Frr values follow patterns similar to those shown by the fire and injury values. By comparison, data from Pomroy and Carigiet [1995] show that during 1978-1992 a total of 11 states were involved in 164 underground coal mine fires (yearly average, 10.8) with 43 injuries (yearly average, 2.9) and 27 fatalities (yearly average, 2; however, the 27 deaths occurred during a single fire caused by an overheated air compressor [MSHA 1984]). The CP value was 5,340 x 106 st (yearly average, 356 x 106 st) (Fn = 0.031). Data on employees' working hours and injury risk rates were not available. Tables 3-8 show the number of fires by ignition source, method of detection and suppression, equipment involved, location, and burning material by time period. Figure 3 shows the major variables during 1990-1999. Table 9 shows the number of fire injuries per number of fires causing injuries and total fires by year, ignition source, equipment involved, and location.

Jan 1, 2004

The production of harmful pollutants from coal mines and/or from coal and associated strata has been a recognizable fact in the United States for over two hundred and seventy years. In 1698, Gabriel Thomas observed(l) that the colored water flowing from streams in this country was similar to that which flowed from the coal mines in Wales. Hence, water pollutants such as acid were being produced before any known coal mines were operating in this country. The coal mining industry has contributed to the increase of pollution by exposing large amounts of sulfide materials that enable the reaction of water, oxygen and sulfur containing materials to form acid. A map of the United States coal fields can be seen on Figure 1. The anthracite regions of Pennsylvania, although small when compared to the total reserves, have produced some of the country's major water problems. The map indicates the extent of bituminous reserves of the Appalachian and midwest regions. Also evident are the bituminous, subbituminous and lignite coal reserves in the west which have recently come into greater demand. Acid mine pollution is encountered in numerous states, but the major problem is found in the Ohio, Susquehanna, and Potomac River basins.(2) Most coal beds contain some sulfur which may be in the inorganic, sulfate, or sulfide form, and thus have the potential to produce sulfuric acid. However, much of the strata that overlays the coal beds also contains acid neutralizing materials. Therefore, the amount of acid produced depends upon the amount of both acid and alkali materials that dissolve in the water in any given mine. The common sources of sulfurous material in the seam or surrounding rock are generally called sulfur balls or "nigger heads" by the miners. Sulfur balls that have been observed(3) seem to be equally divided between those containing sulphuritic iron capable of producing sulfuric acid upon oxidation and those that are primarily calcium carbonate. It has been observed in many instances that two types of water, acid and alkaline, are being produced in the same mine. A study of the geological strata and a survey of subsidence, faults and sulfur balls will usually give some indication of why this happens. The reaction of pyrite (FeS2) with oxygen and water to form ferrous sulfate (FeSO4) and sulfuric acid (H2SO4) by a series of complex chemical interactions is well documented but not well understood.(4,5) However, it is well known that the reactions to form the acid cannot occur unless all three constituents are present. Since pyrite is inherent in most coal seams and air is needed to sustain the miner, the most logical answer is to eliminate water infiltration into the mine, or to remove it from the mine before acids can form.

Jan 1, 1970

By F. E. Cash

The Holmes Safety Association , organized and named in honor of the late Dr. Joseph A. Holmes , first director of the United States Bureau of Mines , has for its object the prevention cf accidents , the improvement of health conditions at work, in the home , and in public places , and the promotion of the general welfare of its members . As a means of preventing accidents and advancing health and safety , the Holmes Safety Association disseminates information , gives instructions on subjects related to safety , and promotes first -aid and other forms of protective and accident - prevention training . This organization is intended to work and cooperate in the closest possible way with existing mine or plant safety organizations in conducting educational , social , and recreational activities for the promotion of health , safety , and efficiency .

Jan 1, 1929

By Elaine T. Cullen

Safety training materials appropriate for specific underground noncoal operations in the United States are often outdated or nonexistent. The Spokane Research Laboratory (SRL) of the National Institute for Occupational Safety and H ealth has developed several new training tools, including three videos on common underground activities, software that will allow trainers to create a virtual training mine using their own mine map, and toolbox training materials. SRL is working closely with industry in the development of these tools. Teams of safety professionals are involved in the early stages, and actual mines and miners are involved throughout the production phase. This presentation describes the development process and results of SRL’s safety training projects.

By B. J. Scheiner

The Federal Bureau of Mines has successfully demonstrated an electrooxidation-solvent extraction-carbon adsorption process for recovering molybdenum and rhenium from offgrade concentrates. The flow sequence consists of dissolution of metal values by electrooxidation, liquid-solid separation by thickening, acidification and chlorate ion removal by sulfur dioxide treatment, solvent extraction to concentrate the molybdenum and rhenium, separation of molybdenum and rhenium by carbon adsorption, and metal recovery by crystallization. Molybdenum and rhenium were recovered as ammonium paramolybdate and ammonium perrhenate. Electrolysis of brine-concentrate pulps to generate a hypochlorite oxidizing agent in situ resulted in the dissolution of 98.9 and 99.1 pct of the molybdenum and rhenium, respectively, at an energy consumption of 13.7 kwhr/lb of molybdenum extracted.

Jan 1, 1976

By Thomas C. Miller, Charles E. Mongan

"This publication is a progress report on Bureau of Mines studies in applying sonar techniques to roof-control problems in coal mines. Preliminary tests in the laboratory were made on layers of roof rock. To apply the experience thus obtained, a unit was designed and constructed and was used underground.The term ""sonar technique"" refers to the system of generating a beam of sound waves, shaping and directing the beam, introducing the beam into a medium to be studied, and examining any returning waves with a view of inferring the nature of the material traversed by the waves and the presence of interfaces or obstacles in the medium.The theory and actual underground experiments indicate that the sonic method is feasible. Information from physical tests made in the Bureau's Experimental mine confirmed the validity and potential usefulness of the sonar method. Lighter and more compact apparatus is desirable, and permissible equipment suitable for use in gassy or dusty mines must be developed. However, no particular difficulties are anticipated; consequently, this scientific approach to the exploration of roof strata shows definite promise. INTRODUCTIONThe problem of roof control in the coal-mining industry is of major importance. More than 50 percent of all coal-mine fatalities and 25 percent of all nonfatal serious injuries are caused by falls of roof, face, or ribs. The Bureau estimates that more than $128 million was spent by the coal-mining industry in 1958 for supporting roof."

Feb 1, 1960

This chapter details the perspective from which collected data have been examined. The first part, intended primarily for lay readers, discusses several topics related to mining as an enterprise. Initially, the organizational functioning of atypical large mine will be described. It is the formal structure above a miner that decides the conditions of his or her work. A second point of concern is the technology itself An underground coal mine is a sociotechnical system, with workers and machines organized in particular ways during production. Third, general conditions and dangers underground will be described in detail. The physical environment of an operation is a powerful factor in the work life of miners. Fourth, a discussion of the process of formal training is given. During this training, a new worker is taught what the organization expects of him or her in the role of safe, productive, coal miner. Next, there are outside organizations that act as significant forces in the workplace. Examples include the Mine Safety and Health Administration (MSHA), State agencies, and the United Mine Workers of America (UMWA). The roles of these entities will also be examined. The second part of this chapter will depict each study site as a concrete setting, so that findings can be interpreted in their proper context. The Organizational and Technical Nature of Mining A coal mine is a complex system. It is defined as all parts of a mining plant's property (both underground and surface) that contribute, under one management, to the extraction or handling of coal [American Geological Institute 1997]. As suggested, many functions that must be carried out at an operation are only indirectly related to coal mining and processing. Even the jobs that are di¬rectly related tend to be numerous and varied [Wallwork 1981]. According to Palowitch [1982], the chief reason for this sophistication is that "after more than two centuries of exploiting our coal resources, today's coal industry finds itself saddled with a horrendous legacy of human impairments and environmental damages which society demands be corrected." Now, the effects of government regulation are evident in every aspect of the mining industry. Any operation, if it is to survive, must be administered with an eye for social efficiency and accountability. Long-range planning is needed to ensure that the mine produces coal in a cost-effective manner. One of the first things that must be considered is location and method of access. To extract coal from an underground mine, a coalbed (or "seam") must be reached from the surface. The term "portal" is generally given to any entrance that provides access to a coal mine. In hilly terrain, such as is found in Appalachia, the coal may "outcrop" on a hillside. This allows direct

Jan 1, 2000

By G. R. Hopkins

According to reports received by the United States Bureau of Mines, Department of Commerce, as of January 1, 1929, there were 2,205 cracking units completed or being built in the United States, with a total daily charging capacity of 1,476,874 barrels. A similar survey of a year ago showed 2,334 units of 1,288,000 barrels total capacity. This indicates that despite a decrease in. number of units, there was a material increase in capacity. The year 1928 was, in general, an important one for the cracking branch of the industry. Gasoline consumption reached record levels, prices were higher than in 1927, and it is probable that in the late months of the year the cracking plants were operating very close to capacity.

Jan 1, 1929

By John Taber, JOHN B. HOPKINS

During World War II , a critical shortage of domestic abrasive corundum developed . Late in 1944 , the shortage became so acute that it was deemed advisable to investigate certain low-grade corundum prospects in Madison and Gallatin Counties , Montana . The Gallatin , the Bozeman , and the Bear Trap deposits were the principal ones investigated . The Bear Trap deposit was examined by E. W. Newman and Robert S. O'Brien , engineers of the Bureau of Mines , in August 1944. Exploration was started in October 1944. Field work was completed late in the spring of 1945 . report presents the data obtained from the exploration .

Mar 1, 1947

By V. A. Marple, K. L. Rubow

"In our laboratory several impactors have been developed in the past which have penetration characteristics that approximate that of the ACGIH or the British MRC respirable curves. In these impactors the large nonrespirable particles are collected on an impaction plate of a multiple round nozzle stage where the nozzles are of different diameters. The principle for designing a respirable cut impactor is quite simple in that the respirable curve is divided into two or more segments and the nozzles are designed with the correct diameters and number of nozzles to have collection characteristics with 50% cutpoints at the center of each segment. The particles not collected on the impaction plates are then collected upon a filter. These particles represent the respirable fraction of the aerosol. Therefore the respirable curve is approximated in a stepwise fashion with the approximation becoming better as the respirable curve is divided up into increasing numbers of segments. It has generally been felt that three segments is satisfactory for most cases.A new version of the respirable impactor has recently been developed in our laboratory. This impactor approximates the ACGIH respirable curve in three steps at a flow rate of 30 liters per minute. However, unlike previous models where all of the particles larger than the three cut points designated by the three steps are collected upon one impaction plate, a separate impaction plate is now used for each of the three cut sizes. To approximate the respirable curve in three steps, the cut sizes must be 2.2, 3.5 and 5.8 microns diameter. Therefore, on each of these stages the particles collected will be the mass of particles that are larger than these three cut sizes. By determining the mass of particles collected on each of these three stages plus that on the after filter using Gravimetric techniques, some information can be obtained on the size distribution of the aerosol being sampled. Furthermore, the impaction plates of the three stages are rotated and the nozzles are placed in such a position such that a uniform deposit is obtained on each of the impaction plates. Therefore, the deposits collected are suitable for X-ray fluorescence analysis or other types of analysis where a uniform deposit is required."

Jan 1, 1988

By C. Travis Anderson

"A recent critical study by Ralston3 of the iron system points out the importance of and necessity for work upon the preparation of ferrous oxide. Not only are ferrous oxide samples desired for determination of the important physical and chemical properties, such as specific heats and heats of formation, bat also information on the stability and behavior of this material is of considerable technical importance. Related. problems where the properties of Fe0 are important have to do with desulphurization of iron, the formation and occurrence of magnetite in copper smelter slags, and sulphur elimination in copperFerrous oxide also has valuable catalytic properties, as is demonstrated in nitrogen fixation.Pure ferrous oxide has never been prepared in quantities large enough to furnish adequate physical and chemical data on its properties. Only two or three experiments4 have produced a fraction of a gram in a state approximating purity and have collected evidence that has been sufficient proof of their having done so. Ferrous oxide is stable only above about 570°C., and below that splits into magnetite and iron according to the reactionUp to about 1920, those who had endeavored to prepare FeO made no provision for rapid chilling, so that although their product. may have had the proper iron oxygen ratio for FeO, in reality it-probably did not consist of pure FeO. The above reaction is reversible; above 570oC. magnetite and iron are supposed to recombine almost completely, and if so, should constitute a direct and easy method of preparation. The data, however, were somewhat conflicting, and the extent to which the reaction goes in either direction needed checking. Preliminary experiments on the interaction of molten Fe304 with solid Fe gave Fe0 of about 85 per cent purity, corresponding to. the approximate purity obtained by some previous investigators. The present work is concerned chiefly with the results cf repeated interaction between partly reduced magnetite and iron, and the calculations which may be made from such results. Repeated treatments are necessary, because molten impure ferrous oxide and iron can not be kept in contact for more than short periods of time."

Oct 1, 1928

1. Data from the Mine Safety and Health Administration (MSHA) indicate that a total of 241,502 employees worked in surface mining locations in 2003, corresponding to 212,113 full-time equivalent (FTE) workers. • Surface employees accounted for 84.6% of all mining employees. • The majority of surface employees (73.7%; n = 177,927) were mine operator employees as opposed to contractor employees. • Stone operator employees comprised the greatest percentage (27.2%; n = 65,743) of surface employees.

Feb 1, 2005

By D. Harrington

"In order to stimulate general interest in mine safety among their employees the mining companies of Butte, Mont., instituted in 1918 a Miners' Field Day, and this field day has since been held annually about the end of July, the last one being on July 25, 1921. The mining companies of the Butte district finance this meet in proportion to the number of men employed at the time of the meet, the contributing companies with number of working force, end proportional contributions for the opening field day in 1918 being given below:COMPANY NUMBER EMPLOYED AMOUNT CONTRIBUTEDAnaconda Copper Mining Co.,12,500,$ 1,078.53Butte & Superior Mining Co.,1,800,155.32North Butte Mining Co.,,1,294,111.67East Butte Copper Co.,,850,73.36W. A. Clark Interests,,600,51.78Davis-Daly Mining Co.,,340,29.35,,,,17,384,$ 1,500.00*Note: In many mining districts it is now the custom to hold an annual Miners' Field Day. The field day, as a rule, is financed principally by the mine operators, and was instituted primarily to promote interest among miners in the ""Safety First"" movement. Usually demonstrations or contests in first aid and mine rescue are the leading feature of the day's events, which include games, races, dancing, and all the other amusements usual to a gala holiday. Thus the field (ley serves the double purpose of stimulating interest in mine safety and promoting cordial relations and community fellowship. This paper is an interesting account of the way in which the Miners' Field Day in the Butte district is organized, with data on costs, plan of organization, method of conducting, and the practical benefits derived from it. - Ed"

Oct 1, 1921

By RUDULF KUDLICH

Pennsylvania anthracite coal is almost universally recognized to be the solid fuel best suited for domestic use when cleanliness , convenience and cost are considered . At various times and in various localities , however, conditions so affect the supply that it becomes insufficient or is too high in price and recourse must be had to other fuels as substitutes . In practically every district in the United States where anthracite has been the common domestic fuel , some other fuel is available as a substitute . In even the most severe climates such fuels are used either as emergency substitutes for anthracite , or as the ordinary domestic fuel . There may be some drawback to the use of such fuel , such as the need of more frequent attention to the furnace , smoke , soot and dust , in the case of solid fuels lower in price than anthracite , but these inconveniences must be accepted as necessary accompaniments to a decreased fuel bill . The cleanliness and ease of handling anthracite in the house must be considered in the light of a luxury and a higher cost of heating with this fuel must be expected . That a growing number of people are willing to pay for such added convenience is evident from the increasing mumber of heating installations using oil , gas and electricity , all of which are more convenient and usually more expensive even than anthracite .

Aug 1, 1923

By Sidney Katell

This Bureau of Mines study estimates typical capital investments, operating costs, and selling prices for two bituminous coal strip mines in the Eastern and Interior provinces and a subbituminous coal operation in the Northern Great Plains province. The annual productions were based on tonnage required to fuel a 250-million-standard-cubic-foot-per-day, high-Btu gas plant. The annual tonnage for the Eastern province mine is 4.8 million tons; for the Interior province mine, 6.72 million tons; and for the Northern Great Plains province mine, 9.2 million tons. It is assumed that the mines have a 20-year life. Wages and union welfare payments are considered as of December 6, 1974, under the terms of the Bituminous Wage Agreement of 1974, and costs for material and equipment are based on 1975 indexes. Initial capital investment varies: $65,137,900 for the 4.8-million-ton-per-year (MM tpy) mine in the Eastern province, $78,514,600 for the 6.72-MM-tpy mine in the Interior province, and $42,050,100 for the 9.2-MM-tpy mine in the Northern Great Plains province. Total capital investments for the Eastern province mine, the Interior province mine, and the Northern Great Plains province mine are $86,969,900, $109,378,500, and $78,543,500, respectively. Corresponding selling prices for the coal, per ton, are $6.94, $6.03, and $3.39, assuming a 15-percent discounted cash flow rate of return after Federal income taxes. These studies are considered typical for the areas involved. Costs will vary depending on specific locations in these areas.

Jan 1, 1976

By NIOSH Publications

In 2004, 14,478 mining operations reported employment statistics to the Mine Safety and Health Administration (MSHA). Almost half (48.9%) were sand and gravel mines, followed by stone mines (30.4%), coal mines (13.9%), nonmetal mines (5.1%), and metal mines (1.7%).

Sep 1, 2007

By Liming Yuan

In order to reduce fire hazards caused by spontaneous combustion in longwall gob areas, a computational fluid dynamics (CFD) study is being conducted by National Institute for Occupational Safety and Health (NIOSH) to simulate the spontaneous heating of coal in longwall gob areas. A CFD model was first developed to model the spontaneous heating process in a two longwall panel district using a bleeder ventilation system with a stationary longwall face. The spontaneous heating is modeled as the low-temperature oxidation of coal in the gob using kinetic data obtained from previous laboratory-scale spontaneous combustion studies. Heat generated from coal oxidation is dissipated by convection and conduction, while oxygen and oxidation products are transported by convection and diffusion. CFD simulations were then conducted to model the spontaneous heating in longwall gob area with a bleederless ventilation system. A single longwall panel with a bleederless ventilation system was simulated. The effect of gob permeability on the spontaneous heating was also investigated.

Jan 1, 2009

By D. M. Lewis, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, J. H. Kang, V. Castronova

"Tetrandrine is a bisbenzylisoquinoline alkaloid which has been shown to exhibit antifibrotic activity against silicosis. Tetrandrine is characterized by its strong binding to alveolar macrophages and inhibition of particle-induced respiratory burst activity in these phagocytes. In contrast, tubocurine and tubocurarine are structurally similar to tetrandrine but exhibit little effect on fibrosis or activation of alveolar macrophages. The objective of the present study was to test the effect of tetrandrine on macrophage production of monokines in response to occupational dusts, and to determine tetrandrine's effect on monokine-medicated cell growth using a mouse thymocyte proliferation assay and lipopolysaccharide (LPS) as a positive control. Stimulation of alveolar macrophages by respirable silica dust resulted in a release of monokines which caused a fourfold increase in thymocyte proliferation. Coal dust, on the other hand, had no effect on macrophage production of this cytokine. Tetrandrine was found to exhibit a dose-dependent inhibition of monokine release from both silica and LPS-stimulated alveolar macrophages. In experiments where thymocytes were directly treated with tetrandrine, a dose-dependent inhibition of thymocyte proliferation was noted with both interleukin-1- (IL-1) specific and nonspecific mitogenic (concanavalin A) actions. In contrast to the inhibitory potency of tetrandrine, tubocurarine was found to have no effect on either the production of monokines by LPS-stimulated alveolar macrophages or IL-I-mediated thymocyte proliferation. These results provide a correlation between the ant:fibrotic effect of tetrandrine and inhibition of macrophage activation. INTRODUCTIONThe pathogenesis of chronic pulmonary fibrosis caused by inhalation of occupational dusts has been associated with abnormal activation of alveolar macrophages such as the release of various cytokines capable of inducing fibroblast proliferation and collagen synthesis. These macrophage-derived cytokines include interleukin-1 (IL-1), tumor necrosis factor (TNF), platelet-derived growth factor (PDGF), transforming growth factor-B (TGF-(B), macrophage derived growth factor (MDGF), and interferon [1, 2].Interleukin-1 is a major macrophage-derived cytokine that has been shown to exhibit multiple biological effects on a variety of target cells. It is known to cause leukocyte [3, 4] and endothelial cell activation [5, 6], and to affect the synthesis and maintenance of the extracellular matrix by stimulation of fibroblast proliferation [7-9], synthesis of collagens [10] and gluco-saminoglycans [11], and prostaglandin E2 production [12]. In addition, IL-1 plays an important role in the initiation of an immune response through its direct activation of lymphocytes and stimulation of the production of other cytokines, such as interferons and hemopoietic colony-stimulating factors, needed for the expression of an immune response [13]. As a major cytokine in the immune-inflammatory sequela, IL-1 is also produced by epidermal, epithelial, lymphoid, and vascular tissues after infection, injury, or antigenic challenge [14]. Agents such as lipopolysaccharide (LPS), phorbol myristate acetate (PMA), immune complexes, and particulates are known to activate the synthesis and release of IL-1 by monocytes and macrophages [15]. These substances also trigger intracellular signals leading to altered arachidonic acid metabolism. Although the mechanism is still not clear, prostaglandins have been shown to suppress IL-1 translation via the induction of cyclic adenosine-monophosphate (CAMP), whereas leukotrienes produce a positive signal for IL-1 production [13]."

Mar 1, 1992

By S. R. Borrowman

Mill tailings from conventional uranium extraction processes contain nearly all of the radium originally in the ore. Such tailings require controlled storage in perpetuity to safeguard the surrounding environment from radioactive contamination. Alternatives to controlled storage of the tailings are (1) removal of the radium from the tailings for separate storage or use or (2) removal of the radium when processing the uranium ore. In laboratory tests conducted by the Federal Bureau of Mines, radium was leached from tailings using either hydrochloric acid or ethylenediamine tetraacetic acid. A hydrochloric acid leaching method was used to extract both radium and uranium from the ore to yield tailings containing less radium than those produced by either conventional sulfuric acid or alkaline leaching processes. From 77 to 94 percent of the radium in mill tailings was concentrated by sedimentation in slime fractions representing nearly 25 weight-percent of the original sample.

Jan 1, 1975