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By Peter J. Barnard

Mitochondria play a key role in the regulation of apoptosis (cell death) and in diseases characterised by abnormal apoptotic responses such as cancer. Mitochondrial membrane permeabilisation (MMP), regulated by the mitochondrial permeability transition pore complex, is widely accepted as being central to the process of cell death. As a result there has been considerable recent interest in targeting mitochondrial cell death pathways in the development of new chemotherapeutic agents.(1) There is potential to overcome the two overriding problems in cancer chemotherapy?the common occurrence of drug-resistant tumour cells and the lack of selectivity of cancer drugs in differentiating between tumour cells and normal tissues. Significantly, carcinoma cells have an elevated mitochondrial membrane potential relative to normal cells and lipophilic cations are concentrated within mitochondria in response to mitochondrial membrane potentials. There is potential for the selective targeting to tumour cells with compounds having optimal lipophilic-hydrophilic character. Research stemming from the early 1980?s points to two distinct classes of Au(I) phosphine antitumour agents where an antimitochondrial mode of action has been implicated: (i) neutral linear two-coordinate Au(I) complexes such as triethylphosphinegold(I) chloride and the tetraacetylthioglucose gold(I) phosphine complex, Auranofin; (ii) cationic tetrahedral bis-chelated Au(I) phosphine complexes related to [Au(dppe)2]+.(2) Recently it has been reported that Auranofin, at submicromolar concentrations, induces MMP observed as mitochondrial swelling and dissipation of membrane potential.(3, 4) Both events are completely inhibited by cyclosporin-A, the specific inhibitor of MMP. The permeability changes were shown to occur at concentrations associated with the selective inhibition of mitochondrial thioredoxin reductase.(3) Auranofin is a potent and specific inhibitor of this enzyme due to Au(I) binding to the active-site selenol group.(5) The redox state of mitochondrial thiols may be critical in the control of MMP.(3) In general, swelling is stimulated by thiol blocking or oxidising agents and is prevented by thiol reducing agents.(1) Mitochondrial thioredoxin reductase may play an import role in the redox control of the permeability of mitochondrial membranes.(3) Our interest is in investigating the antitumour potential of Au(I) phosphine compounds using a number of different approaches. In recent work we have evaluated a series of hydrophilic analogs of [Au(dppe)2]+ containing pyridylphosphine ligands which have demonstrated greater tumour selectivity than the parent compound. To investigate the possible antimitochondrial mode of action we are studying the effect of [Au(dppe)2]+ and related compounds on isolated rat liver mitochondria. To assess whether the lipophiliccationic nature of the compounds determines the antitumour activity, we have synthesized a series of novel Au(I) complexes based on heterocyclic carbene rather than phosphine ligands. The similar chemistry and structural features of the two classes of complexes allow us to assess whether the phosphine ligands are essential for the antitumour properties.

Oct 1, 2003

By Michael R. McPhie

Topics of Discussion 1. The Global Mining Initiative (GMI) and MMSD North America (Brief) 2. Task 2 of MMSD North America ? A Test for Sustainability 3. The Seven Questions and their Application 4. Key Recommendations and Next Steps GMI = Global Mining Initiative Significant international collaborative effort supported by more than 30 of the world?s largest mining/minerals firms which sought to involve all communities of interest. Three major streams of activities: 1. Mining, Minerals and Sustainable Development Project (MMSD) ? 4 regional Process (North America, Southern Africa, South America, Australia) 2. Creation of ICMM (formerly ICME) 3. Major conference in Toronto in May, 2002

May 1, 2002

By K. Adham

Both the dry and the wet fluorination systems require hydrogen fluoride (HF) for the process of uranium conversion to uranium hexafluoride (UF6). The dry methods depend on the electrolysis of HF to generate the fluorine (F2) required for the high temperature pyro-fluorination. The wet methods require aqueous HF in water solutions for the low temperature hydro-fluorination (Argonne, 2019). This paper uses the available HF safety guidelines and industry information to discuss the issues of transportation, storage and utilization. Health effects and environmental considerations are reviewed. Safe practices for handling the HF (both as anhydrous and as aqueous) are considered. Proper selection of different materials of construction are discussed, for both the anhydrous and the aqueous HF.

Jan 1, 2020

By Y. -H. Cho, J. -M. Lee, J. -G. Jung

The effects of copper on the microstructure and mechanical properties of ultrasonic melt treated Al-xCu (x=0, 4) alloys were investigated. The densities of alloys were increased and their grain sizes were decreased by UST. The hardness and electrical resistivity measurements revealed that the amount of solute Cu within Al matrix was increased by UST. Both the yield and tensile strengths of Al-4Cu alloy were increased by UST. The improved mechanical properties of Al-4Cu alloy by UST were probably due to the reduced amount of casting defects (e.g. pore), grain refinement, and enhanced solid-solution hardening of Cu.

Jan 1, 2014

By J. A. Brusset

Introduction I am indebted for most of the information in this paper to Mr. P. S. Lea, Deputy Chief Inspector of Mines of Great Britain, and Mr. A. E. Crook, Engineering Inspector of Mines, Ministry of Fuel and Power. Other coal-mining men in Canada may be as surprised as I was to learn that there are twenty-five Diesel locomotives in service underground in British gassy coal mines. Many more are in use underground in non-gassy coal mines and in metal mines. Approval has been granted for an additional fifty flame-proof locomotives to be used in gassy mines, and these should be in operation by the end of 1946, or as soon as manufacturing facilities permit.

Jan 1, 1946

By E. Hardwick, K. C. Sole, Y. Jurrius

"The Luilu cobalt plant at Kolwezi, Democratic Republic of Congo, has been operating since the late 1950s, using a conventional precipitation flowsheet for removal of impurities from the cobalt process stream. Most impurities are, however, incompletely removed using this technology. Copper and zinc, both of which quantitatively deposit at the cathode in the cobalt electrowinning process, are two of the main impurities contaminating the cobalt metal product. Ion exchange offers a modern approach to removing these impurities from the cobalt advance electrolyte.Following a laboratory testwork programme to identify a suitable ion-exchange system, an on-site pilot-plant trial, treating 1500 to 3000 L/d of electrolyte, was operated for a period of six weeks to optimise the operating conditions and to determine full-scale design criteria. Copper removal was carried out using a fixed-bed lead-polish configuration with the Lanxess iminodiacetic acid resin, TP 207. Zinc removal was subsequently carried out in a similar configuration using the Lanxess aminophosphonic acid resin, TP 260. The optimised system proved capable of removing both copper and zinc from 20 to 30 mg/L to <1 mg/L from plant electrolyte containing ~20 g/L Co. Selective elution allows co-loaded cobalt to be returned to the main circuit and value to be obtained for the copper impurity. The process shows operational and economic advantages over the traditional flowsheet. Full-scale implementation of the developed process is in progress and some design considerations are discussed."

Jan 1, 2014

By Peter Clevenstine

Minnesota Iron Ore Trifecta 1. World Demand 2. Industry Consolidation 3. Competitive Advantages

May 1, 2011

By F. F. Langford

"The Athabasca Basin occupies about 100,000 km2 of the northwest corner of Saskatchewan with its western margin extending about 50 km into Alberta (Fig. 1). The basin is filled with a Helikian sequence of predominantly fluvial sandstones up to 1600 m thick. The sandstone beds are generally flat-lying, and rest unconformably on a crystalline basement which consists mostly of granitic intrusive complexes and quartzfeldspar- biotite gneisses. The basement rocks represent Aphebian sediments and Archaean basement rocks that were metamorphosed and remobilized to varying degrees during the Hudsonian Orogeny (ca 1800 Maj.Since 1968, three mining camps and several substantial unconformity-type uranium deposits have been discovered in the area (Figs. 1 and 2). These deposits lie along the unconformity surface, partially enclosed in sandstones, and partially in the basement rocks. The major deposits have elongate, pencil shaped orebodies that are parallel to the strike of underlying graphitic biotite gneisses. The total tonnage of uranium is in the order of 150,000 to 200,000 tonnes and mining grades range from 0.5 to 2.5 per cent U3O8.IntroductionUranium exploration started in Saskatchewan in 1945 when Jolliffe and Murphy headed field parties to investigate uranium occurrences on the north shore of Lake Athabasca (Kupsch, 1978). Their investigation lead to the development of the Beaverlodge camp in the following years. Some of the early prospectors were impressed by the fact that the uranium occurrences at Beaver lodge were centred on a thick sequence of unmetamorphosed arkosic redbeds which are now called the Martin Group. This sequence was referred to as the Athabasca Series by Christie (1949), and although some occurrences of uranium were found near Stony Rapids and Black Lake, the vast expanse of Athabasca sandstones south of Lake Athabasca was generally regarded as unpromising."

Jan 1, 1986

By J. Desroches, J. Burghardt, N. Whitney, B. Lecampion, A. Surdi, M. Houston, S. Stanchits

There is accepted evidence that multistage fracturing of horizontal wells in shale reservoirs results in significant production variation from perforation cluster to perforation cluster. In fact, only a fraction of the perforation clusters seem to contribute to production in many shale gas and shale oil plays. In many cases, the orientation of the lateral section of these wells is determined by lease boundaries rather than principal stress directions, and these often do not coincide. When horizontal wells are misaligned from the far-field principal stress directions, the fracture must reorient from the near-wellbore principal stress directions, which are aligned with the wellbore, to the far-field principal stress directions. The primary objective of this study is to learn how various completion designs influence the near-wellbore fracture geometry when such a misalignment exists. A secondary objective is to understand the influence of rock fabric features, such as mineralized natural fractures, on this reorientation process. To understand these effects, eight laboratory hydraulic fracturing tests were conducted using a true triaxial vessel with 914 mm × 762 mm × 762 mm samples of Niobrara shale. Several different completion designs were studied, including the use of fracture initiation slots with several different orientations and the use of perforations selectively located to encourage a smooth transition from the near- to far-wellbore region. The tests were carefully scaled as accurately as possible to provide insight into the field near-wellbore phenomena. Pressure and fluid flux at the wellbore, deformation of the block, acoustic velocity, and induced acoustic emissions were acquired during the tests. Additionally, sized particles were also injected to gauge the fracture width away from the wellbore. After the test, the blocks were dismantled, and the fracture geometry was mapped in 3D. These measurements allow one to clearly differentiate the fracture initiation and the breakdown—meaning the peak pressure—to be clearly differentiated; the fracture was already well developed when the maximum pressure was reached. The study reveals non-negligible tortuosity and aperture restriction in the near-wellbore region. In the field, this would translate to high treating pressures, uneven proppant distribution, and possibly near-wellbore screenouts. The test results show that, of the configurations tested, the best approach is to use deep slots that are aligned with the far-field principal stress directions. The oriented perforation design did not achieve the simple, smooth transition that was hoped for, and instead produced multiple competing near-wellbore fractures and considerable tortuosity. The study also demonstrated that the presence of planes of weakness, such as mineralized natural fractures, near the slot tip can result in poor near-wellbore fracture geometries, even for the best completion configuration. We conclude from these tests that the misalignment of the well with a principal stress direction creates near-wellbore complexity that, in turn, creates uncertainty in proppant distribution and, therefore, production; proppant might avoid up to a half of the created fracture. Regardless of the wellbore orientation, this uncertainty is further increased by the presence of mineralized features in the rock fabric that can strongly alter or stop the growth of the hydraulic fracture. Preventing those effects by changing the completion alone proves difficult, and new strategies are required to ensure a reliable stimulation of shales.

Jan 1, 2015

By H. D. B. Wilson

THIS PAPER has resulted from a preliminary draft of a background paper prepared anonymously for the Science Council's Special Study of the Solid-Earth Sciences in Canada. The draft was circulated to eighty-four Canadian geologists; forty-eight of these responded with criticisms of the draft. All critical re-marks were considered carefully and most have been incorporated in the final paper in an attempt to balance the author's bias, although this bias undoubtedly still appears. Indications of support for a particular statement or section were also helpful, because many of these contradicted criticisms and enabled the author to judge the consensus. Thus, all criticism could not be incorporated because the referees did not agree. It is interesting that some remarks were con-sidered overstatements by some and too bland by others. The most perplexing critical comment was one which suggested a new author was needed, and went on to name the existing author as the most likely candidate.

Jan 1, 1970

Presentation Overview Corporate Overview Kutcho Project History Exploration Development Permitting Capstone -Pursuit of Value Building a mid-tier copper producer focused in the Americas Two operating copper mines; Cozamin& Mintomines High grade and low cost 2010 forecast: 80-85 million pounds of copper in concentrates Total Cash Costs* of ~US$1.10/lb to US$1.20/lb of payable copper produced Significant by-products of gold, silver, lead & zinc Growth potential Further expansions at existing Cozamin& Mintomines High grade copper development: Kutcho project, BC Investments in Nevada Copper & Silver Wheaton 100% North American assets Low risk ?Canada & Mexico ?Conventional operations

Oct 1, 2010

By D. G. Sinclair

In any discussion on the subject of mine-safety, it is well to honestly face the fact at the outset that mining is a hazardous occupation and that certain inherent dangers attach to the work, which, in spite of the greatest vigilance on the part of everyone concerned, will from time to time exact their toll of in jury or death from the underground worker. Great progress has been made of late years in narrowing down the range of these necessary risks, and, illustrative of what can be done along these lines by concerted effort, it is pleasing to read from time to time of large operating mines running for weeks, months, a year or more, without a single lost-time accident. To achieve any results in the work of accident prevention it is necessary, first, to have a definite goal, such as a no-accident period, be it a week, a month, or a year, to aim at; and, second, to set up definite standards to work by. The legal code of regulations should form the basis of all standards of work at every mine and should, for this reason, cover as far as possible all conceivable phases of operation. This represents the ideal, but in practice it is unattainable, largely because of the many variables that must be considered, due to the divergence in the scale of operations and to differing geological conditions at the different mines. Hence it becomes necessary for the operator who wishes to attain the maximum in the establishment of high standards of safe operation to so amplify the code as to meet the peculiar requirements of his operation.

Jan 1, 1930

By M. A. Creaney

"The Construction Group is responsible for the construction of all of Placer Dome’s major projects and contributes to the development of most major feasibility studies. This group includes an international collection of Placer Dome people who have built mines in Papua New Guinea, Australia, Chile, the United States and Canada. This paper outlines the changing role of the Construction Group from the early days of single projects to today, when several projects are in various phases from feasibility to construction. The projects’ total annual budgets have from time to time exceeded one billion dollars. IntroductionAs the competition increases globally between the major gold mining companies, the impetus continues to build mines at the lowest cost with the shortest construction schedule. Placer Dome has more than met that challenge by building mines around the world at a pace that was not contemplated 15 or 20 years ago. Since 1960, Placer Dome has built 30 mines and expansions at a cost of nearly 4.5 billion dollars.In the last six years alone, Placer Dome has built 14 mines and expansions, worth 2.6 billion dollars. The company’s success is due primarily to Experience, Innovation, People and Standards.The diversity between projects, let alone the pace, has been a challenge. Placer Dome has built mines around the world in a variety of extreme climates and distinctive cultures. The construction experience gained from these projects has allowed Placer Dome to develop an extensive knowledge and data base making it easier to “fast track” projects.Through the years Placer Dome has developed a human resource base. It now has an experienced and adaptable core team of people able to set up construction projects and build mines anywhere in the world. By developing standards and systems to support the projects they can act as soon as a new project is approved, and complete the projects quickly and effectively. The result is that Placer Dome now has the construction expertise to build its own mines, giving them the competitive advantage that allows them to design and construct a mine in the least time at the lowest capital cost. This was demonstrated in March 1997 with the completion of the construction of two new mines in 12 months."

Jan 1, 1998

By A. Ignatieff

"Excavation, the principal mining process, 'which hitherto has been based largely on the intuition and logic of mining men, is increasingly receiving the attention of engineers and scientists versed in rock mechanics. The paper intro-duce the principles of this science in simplified form, directed both to underground and open-pit mining. Reference is made to the large annual tonnage from ore and rock excavations, which in 1967 were responsible for 250 million tons of mineral production in Canada.The urge to transform excavation into a continuous instead of an interrupted process is discussed with references to the various types of energies employed or proposed in rock breakage or excavation. Due to the rapid decay of applied energy in the discontinuous and heterogeneous rock environment, large confined blasts proposed for in-situ mining do not give much expectation of success as yet. Raises and ventilating shafts are already bored in reasonably hard rock. Tunnelling machines will be used for drifting and cross-cutting in the future, but continuous mining machines of the cuttmg and shearing type are not 'around the corner' for stoping typical orebodies. On the other hand, bed mining, particularly of coal, has led the way in continuous mining, and Remotely Operated Long-wall Face (ROLF) experiments are progressing in an encouraging way. Some reflections on the mining environment in relation to the human element are made."

Jan 1, 1970

By S. W. Marcuson

In the late 1960&apos;s concerns about the natural environment reached high levels within North America and provided activists with suitable platforms for exerting influence over the general public and politicians. In response a host of regulatory mechanisms were developed, statutes, voluntary measures, land grants, codes of practices etc. Emerging environmental awareness from the era provided impetus for rapid technological change that encompassed all industries, especially the base metal business. The resulting clean up impacted all aspects of copper production, dealing with issues such as waste disposal, water and air quality with specific impact on emissions of sulfur dioxide and particulate. This paper provides a perspective of these changes reviewing the macro-economic impact of environmental movement in mining with its specific implications to the copper smelting industry. The fundamental challenges that were faced by the old, but capital-intensive North American plants and the approaches taken to deal with the changing times are reviewed with special emphasis on the conceptual approach to smelter S02 abatement and different paths taken in the USA and Canada. The role of economics, sustainable R&D and presence of technical infrastructure that facilitated the change process is elucidated, and speculations are made about the future state of pyrometallurgy and the natural environment. Cu2007 -

Jan 1, 2007

By D. E. Gill, A. Piche, S. Dufresne

"SOMMAIREUne méthodologie de prévision des coûuts de forage en galeries est proposée. Cette méthodologie a été élaborée pour les perforatrices pneumatiques manuelles. Elle est composée de quatre modèles: (1) un modèle de pénétration conduisant à la prévision du temps de forage; (2) un modèle d&apos;estimation de la durée de vie des fournitures; (3) un modèle d&apos;estimation de fa quantité d&apos;énergie consommée; et (4) un modèle de calcul de couts. Elle fait intervenir la résistance en compression uniaxiale de la roche du massif foré, le diamètre des trous, Ie type de perforatrice utilise, fa pression d&apos;air d&apos;opération, la longueur des fleurets, les temps morts associes au forage ainsi que le rendement des compresseurs, des perforatrices et du réseau de distribution de l’air comprime. L &apos;application de la méthodologie est illustrée à l’&apos;aide d&apos;un exemple, suivi d&apos;une courte analyse de sensibilité et d&apos;une brève discussion. ABSTRACTA drilling cost estimation methodology for underground headings is described. This methodology has been developed for percussive hand-held drills. It comprises four models: (1) a drillability model used for the prediction of the drilling period; (2) a model for the prediction of bit and rod lives; (3) an energy model; and (4) a cost model. It makes use of the uniaxial compressive strength ofthe rock drilled, hole diameter, drill type used, operating air pressure, drilling rod length, dead times that may occur during the drilling operation as well as compressor, air distribution network and drilling machine efficiencies. The application of the methodology is illustrated with an example, followed by a short sensitivity analysis and brief discussion."

Jan 1, 1994

By J. T. Fyles, C. G. Hewlett

"THE TOWN OF Salmo, rail centre for the Salmo lead-zinc mining district, is in southeastern British Columbia 26 miles by road east of Trail an about the same distance south of Nelson. The belt in which the mines occur is a few miles east of Salmo and extends about 6 miles north of the town and 17 miles south and southwest to the International Boundary. The belt includes the H. B. mine of The Consolidated Mining and Smelting Company of Canada, Limited, the Jersey mine of Canadian Exploration Limited, the Reeves MacDonald mine, and the Jack Pot property of New Jersey Zinc Explorations Limited.Since 1949, the Jersey and Reeves MacDonald mines have produced most of the lead and zinc in the district. From 1949 through 1954 these two mines together produced a total of 233,134 ounces of silver, 87,659,399 pounds of lead, 215,708,856 pounds of zinc and 475,397 pounds of cadmium. This amounts to more than 80 per cent of the total production of lead and 95 per cent of the total production of zinc from the district since the first recorded production in 1906. Reserves at the largest properties amount to several million tons of ore containing 4 to 7 per cent combined lead and zinc. Several prospects are potential producers.Regional StructureThe main structural units in the Salmo area are outlined in Figure I, and the major rock units of the stratigraphic column are listed in the following table. The lead and zinc deposits are replacements in a highly deformed limestone formation near the base of the Laib group, and all mineralized zones are on the south and east side of structural unit 2 (see Figure I)."

Jan 1, 1949

By Tom Setterfield

Conclusions ?Canada is a prospective place to explore for IOCG deposits ?Time distribution of IOCG mineralization in Canada mimics that in the rest of the world ?Canada may have been the first country to start mining IOCG deposits ?Production from newly discovered IOCG deposits in Canada may start soon

May 1, 2006

Agenda ?The Context ?The Challenge ?The Solution ?Benefits and lessons learnt from pilots ?Next Steps The Context ?Facilitate management decision making process by supporting the development of value/risk based business cases. ?Large scale investments by extractive industries are expected tobring broad-based benefits to local communities (e.g.: health, education, jobs, infrastructure) ?Investors continue to expect the demonstration of social performance?Specific interventions bring direct value to companies (e.g. skills development) ?Social Investments are key to protecting a company?s license to operate ?Quantifying the value of these investments and planning accordingly, however, has long posed a challenge for the extractive industries and community development practitioners

May 1, 2011

By I. Filzwieser, A. Filzwieser

The Peirce Smith converter is the key metallurgical vessel in the majority of copper smelters. During the two step process, oxygen enriched air is injected through a row of tuyeres into the matte received from a primary smelting unit. Additionally, in the first step the iron content is oxidized into a fayalite slag by the addition of silica. During the second step, the remaining copper sulphide is converted into blister copper with a final sulphur content of approximately 200 ppm. The overall efficiency of this process is determined by the total reaction time, the slag quality and quantity, and the chemistry of the final blister copper. To increase the reaction kinetics during both stages, the METTOP Process Control and Regulation (MPCR) system was developed, which consists of four elements: OPC - Optical product control ACR - Automatic computer regulation GCU - Gas control unit GIS - Gas injection system The OPC system from SEMTECH records the optical spectrum emitted by the off gas flame providing immediate, detailed process information. Using this online data, additional gas can be automatically injected into the converter through a gas injection system opposite the tuyere zone. An improved oxygen distribution in the melt and the accurate determination of the process end point results in a significant reduction in the process cycle time. Furthermore, by maintaining the reaction closer to the equilibrium the final sulphur and oxygen content can be reduced compared to the conventional process. In particular, the final sulphur content can be lower than 70 ppm, eliminating the need for an oxidation step in the anode furnace.

Jan 1, 2007