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By Nelson R. Shaffer

Biotechnology has become a household word of the nineties, and it is expected to become as important in the next century as the computer is in the present. Numerous books and articles portray biotechnology developments as nothing less than a scientific revolution. Almost everywhere one looks new biotechnical breakthroughs are being reported that offer almost limitless opportunities to harness the force of living things to produce materials and manipulate their properties. Biotechnology has been broadly defined as any applications of biological organisms, systems, or processes to manufacturing and service industries. This seemingly new technology is, in fact, one of mankind's oldest scientific activities (Table l), which has been recently revolutionized by techniques of genetic engineering that arose out of basic research in biology, biochemistry, genetics, and information sciences. From fields as old as agriculture and medicine to those as new as monoclonal anti-bodies, transgenic plants, or biocomputers are encompassed by biotechnology. Like most human endeavors, industrial minerals play critical roles in biotechnology. In addition biotechnology holds real potential to improve extraction and beneficiation of certain industrial minerals themselves. BIOTECHNOLOGY OVERVIEW Companies using established biotechnical techniques make up large and diverse groups such as agriculture, chemicals, and pharmaceuticals. The massive US Pharmacopia (Anon., 1990a) provides detailed specifications for minerals used in medicines. Alumina, zirconia, apatite, and bioactive glass have seen service as implant materials (Williams, 1990) and new uses for minerals in health sciences are being actively researched. Agriculture produced $361 billion worth of food and drink during 1991 in the United States; organic chemicals, pharmaceuticals, and enzymes accounted for $68, $59, and $42 billion, respectively (Anon., 1992a). It is not possible to separate the contributions of industrial minerals to biotechnical products, but they represent a very large and rapidly growing new field of uses. The new biotechnology has nearly 300 small companies, plus 15 established companies with 742 biotechnology-related firms (Dibner, 1991b). Revenues exceeded $2 billion in 1990 and are expected to grow to $50 billion by 2000 (Anon., 1992c), with worldwide sales exceeding $100 billion (Burrill and Roberts, 1992). Federal research amounted to $3.4 billion in 1990 (Anon., 1992b). The United States is the world leader in biotechnology, but other countries have large, well-funded programs. Despite debate about safety, obstacles to new biotechnology products are declining (Embers, 1992, Gibbons, 1991). Fifteen biotechnology drugs valued at $1.2 billion (Thayer, 1991a) are on the market, and more than 100 are in various stages of testing (Edington, 1992). Many diagnostic tests are also in use or development (Demain, 1983, Anon., 1992). Large scale efforts to produce or transform important chemicals are also underway (Ng et al., 1983, Hinman, 1991), and research into geologic uses of biotechnology has begun. Much has been published about microbial mining, oil recovery, desulfurization, bioremediation, and other geologic aspects of biotechnology, but this chapter is the first attempt to explore interactions of biotechnology and industrial minerals. This chapter examines uses of minerals in biotechnology; how biotechnology can be used to discover, recover, and beneficiate industrial minerals; and speculates on some potential, but as yet untried uses. Definitions What exactly does the word biotechnology mean? Bud (1989) states that the first use of the term was by Karl Ereky in 1919 to cover the interaction of biology and technology, and in 1933 the term was used in Nature. After citing seven different definitions, Smith (1988) concludes that biotechnology is a series of enabling technologies involving practical applications of organisms or their subcellular components to manufacturing and service industries or to environmental management. Walker and Cox (1988) suggest a definition of "the practical applications of biological systems to the manufacturing and service industries and to the management of the environment." Primrose (1991) says that it is "the commercial exploitation of living organisms or their components." There is essentially an older broad use of the term and a new use. The US Office of Technology Assessment (Anon., 1984) uses a broad definition that includes any technique that uses living organisms (or parts of organisms) to make or modify products, to improve plants or animals, or to develop micro-organisms for specific uses. Definitions are different, but they all have several fundamental elements that include the control, management, or manipulation of living things for commercial, industrial, or useful ends. While such a definition encompasses all of agriculture in practice the "new" biotechnology is restricted to processes involving microorganisms-plant and animal cells, or enzymes. Many consider biotechnology to be recent, but it is one of our oldest technologies as evidenced by the prehistoric origin of brewing, cheese-making, and other techniques. [Table 1] gives some of the important developments in the history of biotechnology. Smith (1988) breaks down historical developments of biotechnology into four phases: 1) prehistoric with no understanding of underlying processes; 2) nonsterile processes; 3) sterile processes after 1940; and 4) genetic and recombinant DNA technology deliberate design of special organisms or processes.

Jan 1, 1994

By R. H. Derammelaere

With renewed interest in coal slurry pipelines in China, Indonesia, Australia and Canada for electric generation, it appears worthwhile to update the relative economics of transporting coal by slurry pipeline. Three slurry pipeline technologies are evaluated for the commercial transportation of 3.0, 6.0, and 9.0 million tonnes per year (MMT A) example cases, over distances of 250 km, 500 km and 1000 km.

Jan 1, 1998

By D. A. Swanson, G. Danziger, G. Savci, C. Barnes

Hydrologic assessments of existing and proposed waste rock stockpiles are typically required for application of operating and closure permits at mine sites. A hydrologic assessment should include an evaluation of climatic data and prediction of the net infiltration rate through the waste rock stockpile surface. In addition, hydrologic factors such as the time required to deplete available moisture storage in the stockpiles and the time required for potential seepage to migrate to the underlying aquifer should also be predicted.

Jan 1, 2000

By H. Barry Holt, Charles A. Bischoff

On November 15, 1990, President Bush signed the Clean Air Act Amendments of 1990. The new legislation is sweeping in its demands for cuts in smog, acid deposition, toxic air pollutants and ozone-depleting chemicals. The Amendments will siqnificantly alter air quality permitting and compliance and are estimted to cost billions of dollars to implement. This article provides an overview and summary of each of the eleven titles of the Amendments. It also addresses how the Amendments will be implemented.

Jan 1, 1991

By K. B. C. Brady, B. E. Scheetz, J. E. Cuddeback, T. W. Bergstresser, W. A. Telliard, S. C. Parsons, R. J. Hornberger

Two weathering procedures are being developed by the Acid Drainage Technology Initiative in cooperation with federal agencies(OSM and EPA). Objects are to: (1) standardize existing humidity cell and leaching column procedures; (2) improve test methods by maintaining a carbon dioxide enriched environment needed to optimize carbonate mineral dissolution, and quantifying particle size variables to evaluate reaction kinetics, and (3) provide flexibility in test method implementation consistent with EPA guidelines for Performance-Based Measurement Systems. Preliminary results indicate the CO2enriched leaching environments produce alkalinities that are similar to field observations and greater than the tests run under atmospheric PCO2. Leaching columns produce higher alkalinity than humidity cells.

Jan 1, 2003

By Philip K. Chan

Batu Hijau is a new copper and gold mine located on the island of Sumbawa in the Republic of Indonesia. This paper details the design and construction of the Batu Hijau overland conveyor, one of the most challenging efforts of the project. The 1.8 m wide, 5.6 km long conveyor has a design capacity of over 10,000 mtph and carries primary crushed ore through the steep mountains of Sumbawa, which necessitated a 160 m vertical downhill section, a 75 m vertical uphill section, ten vertical curves and one horizontal curve.

Jan 1, 2000

Currently the challenge that our society faces is to combine the economic activity for the continuously increasing needs of our expanding population with the necessary environmental integrity and the humanistic social concerns. In this paper, the methodologies that should be applied by the progressive mining industry in order to fall within the frame of the sustainable development are summarized. The Sappes project, an advanced gold mining project in north-eastern Greece, is presented together with the approaches adopted by Thrace Minerals S.A.

Jan 1, 2003

The Waste Isolation Pilot Plant (WIPP) is a geologic repository for disposal of transuranic waste and is operated by the US Department of Energy. The repository is located at a depth of 655 min the Permian age salt beds of the Salado Formation. The exhaust air from the facility is independently monitored by the Environmental Evaluation Group to verify compliance with regulatory release limits for radioactive materials. A May 1995 video inspection of the exhaust shaft identified fluid migration into the uppermost 25 m of the shaft. Since then, water has been observed flowing in from cracks in the shaft lining between 16and 25 m below surface level at an estimated rate of between 5 and15 m3/d. This water inflow has not only negatively impacted the equipment in the shaft, associated duct-work and monitoring equipment located at the top of the shaft, but also challenged efforts to verify compliance at the WIPP. This paper provides an analysis of these effects.

Jan 1, 2004

By Paktunc. A. Dogan, Nand K. Davé

Unsegregated pyritic uranium mill tailings from Elliot Lake, Ontario, with and without limestone amendment, were subjected to column leaching experiments for the purposes of predicting the onset of acidic drainage and the magnitude of metal and radionuclide release under various treatment and control strategies. The unamended tailings produced acidic drainage after approximately one and a half year. The tailings mixed with various grain-sized limestone did not produce acidic drainage during the study period. The tailings consist essentially of quartz, K-feldspar, muscovite and pyrite. The unsegregated tailings amended with very fine limestone displayed the least amounts of pyrite loss whereas those without limestone amendment had the greatest pyrite losses. Predicted onset of acid generation varied from 16 to 75 years for the top sections and in most cases greater than 100 years for bottom sections of the unsegregated tailings with limestone amendments. Unsegregated tailings mixed with fine- and very fine-grained limestone proved to be the most effective in controlling or delaying the onset of acidic drainage under unsaturated conditions.

Jan 1, 2000

By D. R. Babich, E. R. Bauer

Noise induced hearing loss (NIHL) continues to be a problem in the mining industry. New noise standards (Part 62) promulgated by the Mine Safety and Health Administration (MSHA) are aimed at reducing NIHL in the mining industry. The National Institute for Occupational Safety and Health (NIOSH) is conducting a cross-sectional survey of noise sources and worker noise exposures to address NIHL in mining. Noise surveys, including full-shift worker noise exposure and equipment noise profiling, have been completed in several surface coal mines, with an emphasis on draglines. The results of these studies are reported, their implications concerning worker NIHL are addressed, and their application to administrative and engineering controls is discussed.

Jan 1, 2003

By Brian H. Jasperse, Nicholson Peter J.

Gravity retaining walls have been constructed using Deep and Shallow Soil Mixing (DSM and SSM) since 1991 in the United States. These walls, for both temporary and permanent uses, were constructed by mixing cement with in-situ soils over a volume containing 100% of the required gravity wall zone. Modern design techniques have reduced costs substantially by forming the required gravity wall section as a composite mass. Using ratios of 15-35% by volume, treatment f the ground forming the required gravity section has reduced the cost from about $40 to about $20 per square foot. Design, construction and actual performance of these gravity walls are presented.

Jan 1, 1999

By Winfield G. Wright, Philip L. Verplanck, Philip L. Hageman, Douglas B. Yager, Dana J. Bove, M. Alisa Mast

Geological, hydrological, and geochemical information synthesized in a Geographical Information System (GIS) for water and rock surrounding South and Middle Forks of Mineral Creek, northwest of Silverton Colorado, was analyzed to distinguish between the natural and the mining-related sources of metals to dace waters in the watershed An important natural source of metals to surface water emanates from a porphyry molybdenum deposit south and upslope from the Middle Fork of Mineral Creek. Interaction of surface and ground water with fractured, altered rocks and permeable, Quatemay-age surficial deposits produces downstream water quality that does not meet current State of Colorado water quality standards for metals and pH. GIS site characterization and three-dimensional modeling distinguish surficial deposits as volumetrically substantial, significant sources of naturally occurring metals that strongly influence water quality and complicate ongoing mine-site mitigation efforts. Our findings indicate that regional hydrologic and geologic information needs to be evaluated before realistic water quality guidelines are established and mitigation recommendations are confidently implemented.

Jan 1, 2000

By V. K. Kollipara

Dust dispersion characteristics in mine airways are important for developing engineering controls for dust and explosions. Authors here have used CFD modeling approach to analyze the dust dispersion characteristics in mine airways. The technique was initially validated with the published field experimental data. The results obtained were in a reasonable agreement. CFD validation results show that in a single entry the dust concentration decreases exponentially as a function of distance. Finer particles can travel up to a distance of 350-400 m away from the source. Parametric studies indicate that air velocity and input dust concentration has significant influence on dust concentration distribution. CFD modeling was then applied to study the dust dispersion characteristics in a room-and-pillar mine layout. Preliminary results show that dust concentration distribution is highly dependent on the airflow patterns and air velocity distribution. The distribution is not exponential until the velocity in the travel way becomes uniform. Data developed in this study may be used to design mine layouts and engineering controls for dust control and explosions.

Jan 1, 2011

By Gordon T. Clark, Stephen H. Gleaton

This paper discusses the conceptual design of cut-and-cover tunnels currently being considered as one of the replacement options for the earthquake damaged, elevated double-deck highway and seawall built in downtown Seattle 50 years ago. The 4.8 km (3 mile) long, 6-lane improvement consists of 1.6 km (1 mile) of at-grade roadway with aerial interchanges, 1.6 km (1 mile) of large two-level cut-and-cover tunnels along the Elliott Bay waterfront, and retrofit of the 50-year old, 1.6 km (1 mile)long Battery Street tunnel and north transition to grade. Construction of deep cut-and-cover tunnels, in complex glacial geology overlain by hydraulically placed fill immediately adjacent the existing sea wall, will require extensive use of concrete diaphragm walls, ground improvement and dewatering. The potential liquefaction and lateral spreading of the fill materials in this active seismic region pose significant design challenges and risk.

Jan 1, 2003

By Gary R. Krieger

Baseline Risk Assessment: - Data Collection and Evaluation - Exposure Assessment - Toxicity Assessment - Risk Characterization Lead - Problems and Pitfalls: - Sources - Pathways - Receptors - Toxic Endpoints - Modeling Options - Health Based Clean-Up Options

Jan 1, 1990

By Arun Kumar Singh

Wide variation in the nature of the coal seams and the surrounding rock mass of the Indian coalfields and very little information about the associated stress fields were observed to be the major hurdles in the straight forward application of a continuous miner (CM) based mechanised depillaring approach. Due to various techno-economic reasons, a considerably large number of coal seams have been developed and are standing on pillars in India. The development of pillars is done as per Indian coal mines regulation, which results in pillars of relatively large size. In fact, the large size of the pillars provides stiff natural support to control caving of the massive overlying strata. However, the size of these pillars is not conducive for the single pass pillar stripping technique and, therefore, there is a need for pillar splitting before pillar extraction/retreating. Splitting of the pillar may reduce the competency/stiffness of the pillar, which creates a chance of overriding during final extraction below a massive roof stratum. This paper first discusses the existing coal mining scenario in India followed by a brief presentation of geo-technical details of pillar extraction at the three sites where a CM has been introduced for depillaring/pillar retreating in the country to date. Based on past rock mechanics experiences with conventional depillaring faces, stability issues of the pillars, fenders, and stumps in and around the depillaring face are discussed. This may prove to be an important factor in the success of future CM faces. It is recognized that the application of the modern strata movement monitoring techniques may improve operation safety by providing valuable qualitative and quantitative information that can be used to improve the design of modern concepts like roof bolt based breaker line support during pillaring.

Jan 1, 2009

By Dell H. Adams

Coal exploration may be defined as the acquisition of data necessary to define and acquire a block of coal which can be mined at a profit. Unlike ore minerals, coal resources are widespread and relatively abundant with supply exceeding demand in almost every case. Thus simple discovery of coal is generally not enough. The chemical and physical variability of individual coal seams, the capital intensive nature of coal mine development, and the changing patterns of utilization require that a multiphase, three-dimensional evaluation be made of each potential reserve. Factors which must be investigated include not only the quantity and quality of the coal but also the geologic, hydrologic, and engineering characteristics of the seam and its surrounding strata. Acquisition of property to provide a secure base for exploration and mine development is equal in importance to the geologic and engineering programs. The successful development of a coal reserve requires that control of coal and, in the case of a strip mine, the surface be in the form of contiguous blocks of sufficient size to support mining.

Jan 1, 1981

By G. Blackwell, E. Bozorgebrahimi

The trend in open pit mining has been to maintain cost competitiveness through economies of scale, particularly by implementing larger trucks and shovels. This paper considers the potential adverse impact of such scale adjustment, however, on dilution, maintenance, flexibility, and other aspects of operations. It examines the mine production characteristics affected by increased equipment size and attempts to quantify the impact on the overall operation. Reference is made to data from operations that have experienced a variety of equipment size ranges changes over the last decade.

Jan 1, 2003

By Y. B. He

The effect of the stability and rheological properties of magnetite dense medium on the separation performance of a 6" dense medium cyclone (DMC) is studied with the use of fine density tracers. The tests in which different size fractions of magnetite are used to prepare the dense media reveal that at low medium densities (<1.5 s.g.), the best separation is achieved when using the magnetite with intermediate particle sizes (du3.2=18 11m). At medium densities above 1.5 s.g., however, it is beneficial to use coarser magnetite. With the fine magnetite dense medium, an increase in medium density results in a decrease in separation efficiency. With the coarse magnetite, an opposite trend is observed; the separation efficiency is improved with increasing medium density. An accurate cutpoint control is critical in gravity separation. The cutpoint shift for coarse feed particles is found to decrease with increasing medium stability (density). It assumes values close to zero in a highly stable fine dense medium. When the size of the treated particles is small (<0.5 mm), the cutpoint shift is mainly determined by medium rheology. With increasing medium density, a continuous increase in cutpoint shift is observed.

Jan 1, 1993

By J. Y. Kim, R. W. Stanley, L. Rosato

Silver contained in zinc calcines undergoes several phase changes as it proceeds through the leaching circuit of a roast-leach-electrowin zinc plant. In this study, the flotation response of silver, from leach residues prepared under a variety of carefully controlled operating conditions in the pilot plant has been examined. Flotation of neutral leach residue is shown to be technically viable and to merit consideration for those plants without a high-acid leach circuit, but having significant silver values in the feed. Residue leach conditions must be kept slightly acidic to promote the formation of Ag2S, (AgCu) 2S and Ag2S rims on residual unroasted sphalerite, while simultaneously avoiding the hydrolysis of soluble iron, which depresses silver recovery and grade. Factors to be considered during integration of a flotation process into an electrolytic zinc plant are discussed.

Jan 1, 1992