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By J. H. Zhang

An atomic force microscope has been used to measure the forces acting between two silica and two rutile surfaces in the presence and absence of cationic surfactants, CnTACl (n = 12~18). The forces measured in the absence of surfactant can be fitted to the DLVO theory. At short separations, however, the silica surfaces exhibited repulsive hydration forces, while the rutile surfaces did not. On the other hand, the forces measured in the presence of the cationic surfactants show long-range attractions that are larger than the van der Waals forces. The long range attractions are the strongest at of the point of charge neutralization (p.c.n.), which decreases with increasing surfactant chain length. The possible origin of the long-range attraction has been tested in view of the charged-patch model of Miklavic et al. (1994). However, the sizes of the patches back-calculated from the model were much larger than those the patches (or hemi-micelles) determined experimentally and reported in the literature. It is, therefore, suggested that the long-range attractions observed in the present work are due to the structural response of the water molecules in the vicinity of hydrophobic surfaces.

Jan 1, 2014

By G. B. Harris, C. W. White

Cyanide has been used for the recovery of gold since the mid 1800s, but several jurisdictions have already banned its use, and environmental pressures are increasing to finding an alternative. Gold also forms chloride complexes similar to those of cyanide, but the use of chloride has never achieved widespread acceptance. This paper describes a chloride-based flowsheet, wherein the key unit process is the recovery and recycle of chloride ion. It is shown that the chloride-based flowsheet is competitive economically with the conventional cyanide-based flowsheets, and that it has a number of other advantages, particularly environmentally.

Jan 1, 2011

By Steve W. Webb

The Bureau of Mines is researching a new technology for dewatering clay suspensions that consists of flocculation by high-molecular-weight poly-ethylene oxide (PEO) polymer and subsequent removal of water from the floes via a trommel. The minimum amount of PEO required to dewater the clays depends on the ions adsorbed on the surface of the elay particles. Infrared studies were performed on clays with Li+, NH4+, K+, Mg2+, Ca2+, Ba2+, or 8r2+ adsorbed, with and without adsorbed PEO, to develop data to aid in understanding the dewatering mechanism. Hydroxyl stretching modes between 3,400 and 3,250 em-I, associated with water adsorbed on the clay, showed changes in intensity proportional to the ionic eharge-to-radius ratio; that is, the ionic potential. In addition. a water-bending vibration of adsorbed water at 1,630 cm-1 showed variations associated with water desorption. The data are consistent with changes in adsorption of PEO resulting from variation of the acidity of water coordinated with the exchange ions, induced by the variation in field strength of the ions with the ionic potential.

Jan 1, 1986

By Chang-Young Choi

Korea Zinc commenced zinc production in 1978 with a capacity of 50,000 tpa. Since then, continuous investments have been made and resulted in Korea Zinc now being the biggest zinc and lead producer in the world. In the course of increasing zinc production capacity, the company management realized that the company needed a lead smelter to prevent the solid waste disposal problems by treating the lead containing solid waste. This paper begins by briefly stating the objectives and the roles of the lead smelter at Onsan. It describes the QSL process and the TSL process, and further extends the description of the TSL process, through which harmless inert solid waste could be produced for secure final disposal. It is also mentioned that the TSL process plays an important role in the integration of zinc and lead production. Throughout the paper, a positive attitude in handling the environmental issues in the non-ferrous smelting industry is emphasized. Finally, a solution for the solid waste disposal problem in the zinc and lead industry is proposed, with which the environmental issues can be an opportunity rather than a crisis. The current operation at Ousan suggests the future direction of the non-ferrous smelting technology that all of the zinc and lead producers should pursue.

Jan 1, 2003

By Vas Choudhry

The eighties are likely to witness the first commercial-size coal-to-gasoline plant(s) in the U.S., although uncertainty regarding crude prices and cautious involvement of the Federal Government in the synfuels development are evident. The formation of The U.S. Synthetic Fuels Corporation with passage of the Energy Security Act is projected to pave the way for some of the projects on a moderate scale. The corporate objectives (1) are to provide funds for supporting a number of feasibility studies and loan guarantees for the construction of at least some commercial-size plants and the possibility of product price supports or purchase commitments. There are a number of coal conversion processes (2) currently under evaluation for producing either gaseous or liquid plus gaseous fuels, the other processes such as SRC I are for producing desulfurized deashed clean solid fuel for commercial use.

Jan 1, 1982

During a period of six months in FY2018, a series of trials were conducted to compare drilling accuracy using two different methodologies and the subsequent impact this had on ore dilution. Testing was conducted at Cracow underground gold mine in Queensland, Australia. The drill rig’s existing alignment process was compared to a new technology system with the following observations: - Using the existing alignment process only 20% of holes surveyed recorded toe points within the +/-300mm (11.8in) tolerance blast-hole deviation. - The new technology was proven to limit rig alignment error, reducing average blast-hole deviation and increasing the number of holes drilled within tolerance by 160%. The increased accuracy reduced stope dilution by reducing over-break of subgrade ore: - Stopes drilled using the new technology recorded 62.6% less average dilution. - This contributed to an overall reduction in dilution for the full year (FY18) of 5 percentage points compared to FY17 - from 22% to 17% (a net decrease of 22.7%). A cost-benefit analysis extrapolated from the trials stipulates that if the new technology were in use for a full 12 months, when applied to FY17 full year data, a 10 percentage point reduction in dilution would represent a net 45.4% decrease, and would result in AUD8.2M (USD5.9) additional ore recovered, with AUD4.5M (USD3.2M) less spent on wasted cost of haulage and processing of diluted ore. As a result, return per tonne would increase 22%, from AUD87 (USD63) to AUD106 (USD77.1). INTRODUCTION Dilution – planned and unplanned – remains a significant cost impairment in the mining process. A series of trials were held over a six-month period in FY18 which established the cost-benefit of new technology as it applies to the alignment accuracy of production drilling rigs in underground mining, thus confirming its ability to limit drilling as one of the causes of dilution. The trials identified three underlying factors affecting drilling accuracy, measurable by blast-hole deviation surveys of planned vs actual toe data. These were; rig alignment error, collar location change/error, and in-hole deviation. The trials involved a comparison of existing rig setup processes and technology, with the new technology (Minnovare’s Production Optimiser system). The trials were undertaken in the same environment; an operating underground gold mine - Cracow Gold Mine. The comparison first revealed the extent to which rig alignment impacts blast-hole deviation. Secondly, the new technology was proven to limit rig alignment error, thereby reducing average blast-hole deviation and increasing the number of holes drilled within tolerance by 160%.

Jan 1, 2019

By J. E. Terry

This paper outlines the steps that are being taken to close the gap between training and industry and indicates areas in which more work needs to be done. Although based on experience in the Maritime Provinces, it is applicable to industrial and educational studies across the length and breadth of Canada.

Jan 1, 1970

By R. S. C. Smart

Surface chemical factors, including the balance of hydrophobic (e.g. collectors) and hydrophilic (e.g. oxidation products, precipitates) species, are major control determinants in flotation rates of specific minerals and therefore grade and recovery. There are a number of challenges involved with the surface analysis of different mineral phases from process streams in a flotation facility. The first is to collect samples that are representative of the process and retain their surface chemistry prior to introduction into the instrument. The second challenge in studying the surface chemistry of specific minerals is to find reliable methods of mineral phase recognition. In surface analysis of mineral particles, confident mineral selection can be difficult with many multi-metal minerals and with precipitated, adsorbed, reacted and contaminant species in the outermost molecular layers. The third challenge is to provide a statistical surface analysis of multiple grains of the same mineral. Methods to achieve these aims are described. Principal component analysis (PCA) of ToF-SIMS data provides improvement in phase recognition, particle selection and associated variations in surface species. Specific examples from both lab and plant operations, demonstrate that this technique can be utilized to differentiate surface chemical factors promoting (hydrophobic species) or inhibiting (hydrophilic species) flotation. A study of copper ion transfer (inadvertent activation) from chalcopyrite to pyrite and sphalerite clearly identified a statistical difference in copper intensities between the sphalerite and pyrite phases corresponding to their flotation response. The PCA analysis applied to concentrate and tails samples collected from the Inco Matte Concentrator demonstrated extensive CuOH and NiOH transfer between chalcocite and heazlewoodite minerals. The statistical analysis has been able to identify mechanisms controlling recovery and selectivity. High intensity conditioning (HIC) tests in which sphalerite was separated from a complex sulfide ore gave a 5% increase in the overall Zn recovery. The PCA/ToF-SIMS statistical analysis revealed the discriminating depressant action of adherent aluminosilicate (gangue) fine particles and adsorbed ions on the surface of sphalerite grains. HIC conditioning resulted in the removal of these gangue fines improving surface collector attachment efficiency.

Jan 1, 2014

To enable ammonium nitrate-fuel oil (AN-FO) to be used on an equal weight basis with nitroglycerine explosives, smaller diameter bore holes became necessary with consequent modifications to drill steel and burden on holes. Detonation of AN-FO in small diameter holes proved successful both with and without primer charges but some alterations were required to adapt anoloders to the smaller holes.Important factors in training all operators in the new charging method were the retention of improved fragmentation, avoidance of excessive overbreak and keeping wall rock dilution to an absolute minimum. The successful storage of ammonium nitrate in climatic conditions with daily temperature fluctuations above and below the critical 90°F has been achieved.INTRODUCTIONTechnical aspects of ammonium nitrate-fuel oil (AN-Fa) blasting agent are well covered in recent literature. This paper deals primarily with the manner of its introduction as the principal explosive underground at Great Boulder Gold Mines Ltd. and with the many problems encountered in the process. Following reasonably successful experimental firings in June 1962', using granular ammonium nitrate and an anoloder, permission was granted by theWestern Australian Mines Department to carry out test work in selected areas of the mine. The permit allowed for fuse firing only, and for a mixture of AN-Fa containing between 5t and 6 per cent fuel oil, with an adequate primer.The use of AN-Fa on an equal weight basis with nitroglycerine explosives, involved smaller diameter holes with alteration to ground burden and modification to drill steel.Initial tests indicated that it was apparent that AN-Fa could not replace gelignite on an equal weight basis if the...

Jan 1, 1965

By M. A. El-Sayed

"Double oxide films (bifilms) are significant defects in light alloy castings that occur when, during melt handling, the oxidized surface of the melt is folded over onto itself and then entrained into the liquid metal, encapsulating a portion of the local atmosphere. These defects create crevices in the final castings and have been shown to decrease tensile and fatigue properties, and also to increase their scatter, making casting properties unreproducible and unreliable. This paper reports on two different experiments performed to study the behaviour of such defects in Al alloys. In the first experiment and as a proxy for a bifilm, air bubbles were held in an Al-5Mg alloy melt for varying periods of time before the melt was allowed to solidify. The composition of the gas content of the bubbles was subsequently analysed using mass spectrometry to ascertain how it changed with time. In the other experiment the influence of the age of bifilms on the mechanical properties of Al-5Mg castings was assessed by holding castings in the liquid state for different times before solidification, followed by mechanical property testing and SEM and EDX studies of the fracture surfaces of tensile test bars. This research could provide a better understanding of the behaviour of double oxide film defects, and may lead to the development of new techniques by which these defects could be eliminated, or at least deactivated, in light alloy castings. Introduction One of the major structural defects affecting the reproducibility of mechanical properties of aluminium castings is the double oxide film defect (El-Sayed and Essa, 2017; El-Sayed and Ghazy, 2017). This type of defect is usually created as a result of poor filling system design. Owing to the very high reactivity of liquid Al-Mg alloy with oxygen in the air, the surface of the liquid metal can be considered to be permanently coated with an oxide film (Weigel and Fromm, 1990). As a consequence of surface turbulence, the oxidized metal surface can become folded over onto itself, but not fused, and then submerged into the bulk liquid, with a portion of the mould atmosphere being entrapped within it (Campbell, 2003; Al- Sayed, 2016; El-Sayed, Hassanin, and Essa, 2016)."

Nov 1, 2018

By D. A. Rice

In pelletizing magnetic iron ore concentrates, about 6 to 18 lb of bentonite binder are added per ton of concentrate during balling to give green and dry strengths to the unfired pellets. The dry bentonite is mixed into the filtercake following the magnetic concentration circuit of the plant. The filtercake contains about 10% moisture, and the water may be of highly variable composition, depending on the particular concentration circuit, its source, and the ore being treated. A knowledge of the parameters that influence the balling operation is essential for optimal efficiency in producing balls strong enough to survive the treatment during transportation from the balling device to the furnace and during the firing operation. Furthermore, very weak unfired pellets probably contribute to high dust losses and poor furnace control. The factors that determine the strength of unfired pellets have received considerable study (1,2,3,4). Tigerschiold and Ilmoni(l) pointed out the significance of the surface area of the particles being pelletized. Merklin and Childs(2) reported on the effect of material size consist, chemical additives such as soda ash, lime, balling time, ball size, and the moisture content of green balls. Iwasaki and Zetterstrom(3) examined the detrimental effects of fatty acids on the pelletizing process. Stone(4) correlated the zeta potential of bentonites with the strength of unfired pellets. He found that, in general, a high negative charge on the bentonite is conducive to good balling. Although studies of pelletizing in the iron ore industry deal with a complex multicomponent system consisting mainly of the iron mineral, bentonite, and water, the last of these has received little attention, particularly with regard to the possible effects of mill water chemistry on the pelletizing process and the strength of unfired pellets. It is widely known that the composition of mill process water is an important variable in unit operations such as flotation, thickening, and filtering and that impure water can lead to poor metallurgical results. The results of the present study indicate that the chemistry of the mill water may be an important variable in the balling operation as well. Knowledge about this variable should contribute to lowering bentonite and oil consumption and to improving furnace performance. Such knowledge can also assist those who use balling in evaluating commercial bentonites for plant use as well as those investigating balling from a more fundamental point of view In this study we have examined 1) the effects of replacing mill process water in the magnetic concentrate filtercake with pure water, and 2) the effects of several chemical impurities that are commonly found in mill process waters upon the strength of unfired pellets. The results are interpreted in terms of the zeta potential of the bentonite and magnetite particles. The data lend support to a suggested mechanism whereby the electrostatic attraction of oppositely charged particle surfaces causes bentonite-bentonite and magnetite-bentonite bonding. This mechanism would also explain why several chemical additives e.g., sodium carbonates and phosphates, have such marked effects on increasing the strength of unfired pellets.

Jan 1, 1971

By John A. Church

Jan 1, 1880

By R. Duinker

"This paper, an update to the 2003 paper titled "Knowledge, Technology and Profit" (Twigge-Molecey, 2003) analyzes 45 "problem projects" from the mining and metals industry over the last eleven years representing $133 billion in CAPEX. The projects have been designated as "problem projects" as they did not meet their owner’s initial expectations for project performance as defined in the paper. This paper explores some of the challenges that were present, through interviews with the knowledgeable individuals that were familiar with the projects and investigations using publically available information. The aim of the exercise was to identify the key challenges faced by the projects, and the contributing factors that led to the project failures so that the lessons can be applied to future projects.The project challenges have been categorized into four themes, technical, organizational, environmental & social and missing "homework" prior to board approval. Of noteworthy interest is that environmental permitting aspects have risen to become a significant and notable contributor to problem projects in 11 years from 2003 to 2014. It is further observed that many projects have been challenged by increasing size and complexity and with execution in more remote locations since the previous paper.It is a reality that every project will face challenges. Some projects are simply more challenging than others, and success or failure of the project is often determined by whether the project team is fully prepared to respond to the challenges. This in turn is largely dependent on whether the project "homework" was adequately completed and considered for all aspects of the project."

Jan 1, 2015

By H. B. Merlin

"The past demands for energy and the contributions by the major sources are shown for the world and regions, and for Canada. Three forecasts of future demand are presented. By the year 2000, the world will be consuming energy at a rate of 670-700 x 1015 Btu/year. Canada's rate is estimated at 20 x 1015 Btu/year. Electricity will increase its portion of energy from 7.5 per cent to 15 per cent, and more than 40 per cent of the primary energy w1ll. be required to generate 1t. World, regional and Canad1an forecasts are g1ven for total electricity generated and for electricity generated in nuclear stations. The integral world requirement for energy by the year 2000 will be over 12 x 10 18 Btu. Current recoverable fossil and hydro reserves are about 18 x 1018 Btu. The total reserves are estimated to be seven times greater.World production of electricity in nuclear stations by the year 2000 will be almost three times the electricity produced in the world today. The amount of fuel consumed in generating this electricity will depend upon the types and mix of reactors installed. The heavy water reactors, alone or in conjunction with fast breeders and liquid fuel reactors, are the most efficient users of uranium and thorium resources. The heavy water reactors are also the most efficient producers of plutonium which will be required as fuel for fast breeders."

Jan 1, 1969

By Hidenori Hatta, Takero Watanabe, Hideo Yoshida

"The effect of the quenching rate on age hardening in an Al-6.0mass%Zn-0.75mass%Mg alloy sheet was investigated. The quenching rates and aging conditions were as follows: water quenching (WQ) or furnace cooling (FC) followed by pre-aging at 20°C,then artificial aging at 120, 160 or 200°Cwere performed. The peak strength of the FC and the WQ are very similarat120°C aging. It is important high strength was obtained even at the extremely slow quenching rate. On the other hand, the strength of the WQ significantly decreased compared to the FCat200°C aging. GP(I) zones were formed during the pre-aging at 20°C even if the cooling rate was very slow like the FC, and were transformed into the GP(II) ones at 70°C or higher and then into the ?’ phase. However, these zones were dissolved by reversion during heating to 200°C. Thus the strength of the WQ decreased. On the other hand, it is considered that an unknown cluster or GP zone with a thermal stability formed during the FC was not dissolved up to 200°C and was transformed into the ?’ phase. Therefore, a higher strength was obtained in the FC for the200°Caging.INTRODUCTIONAl-Zn-Mg alloys are widely available in commercial production because these alloy have lower quench sensitivity and can be produced by air cooling (AC). Heat treatable aluminum alloys are usually produced by water quenching (WQ) to increase their strength because a high cooling rate inhibits the precipitation of the stable phase during cooling and increases supersaturated solute atoms. However, Baba(1967)reported the strength of an Al-6%Zn-1.8%Mg(mass%) alloy without additional elements quenched by very slow cooling (15°C/min) was 96% of that quenched by WQ. Furthermore,the age hardening at room temperature (RT) occurs after annealing at 410°C followed by furnace cooling (FC, 0.5ºC/min or less)in these alloys. Therefore, the process of annealing at 410 to 430°C for 120 min followed by AC, and reheating at 230°C for 240 min, then cooling is recommended in the specifications (Japan Aluminum Association, 2011). Matsuda and Yoshida(1996)also recommended annealing at 300°C for Al-Zn-Mg alloy extruded products to inhibit age hardening at RT by precipitating the solute atoms and decreasing them in the matrix. It has been considered that the higher the content of excess quenched-in vacancy becomes by WQ, the higher aging rate at RT is obtained. Therefore,it is theoretically and commercially important to clarify the reason why the age hardening occurs relatively quickly in almost no excess quenched-in vacancies such as the FC, and why the same strength as the WQ can be obtained in the FC"

Jan 1, 2018

By J Jackson, M F. Young

"Ore is the economic portion of a mineral deposit that can be extracted economically. Hence an ore type is a classification of the ore based on one or more dominant characteristics in order to enable communication between unit operations and/or technical disciplines.In project evaluation, ore types are often defined early based on geological observations by geologists and initial metallurgical testing is based around this classification even though a number of processing options can be under evaluation. However, the geological drivers of performance for each of these processes can be very different and the ore type classification for one process may not be relevant for another. In operations an ore type, as either defined in the project evaluation phase or those that evolve with additional knowledge, is unlikely to provide the knowledge required across all the unit operations. The ore type has a meaning to someone but does not necessarily for all unit operations across the value chain.Geometallurgical or orebody knowledge has evolved through the consideration of multiple processes within the value chain, the improved understanding of variability of process performance within ore types and the effect on the complexity of the mineral extraction processes. Furthermore orebody knowledge has been moving from personal based knowledge and understanding to a more process oriented approach where measurement and spatial and process performance modelling is playing a greater role. Advances in mine planning and scheduling allow for both detailed analysis of the block model and the expected extraction processing attributes across various time scales. This capability of analysing and describing the complexity still requires to be communicated to the various unit operations, which may be beyond the traditional classification of an ore type.The limitations of an ore type and potential alternatives to enable the relevant information to be communicated to the relevant groups are outlined through a number of case examples across the value chain.CITATION:Jackson, J and Young, M F, 2016. Ore Type – Everything to Someone but Nothing to Anyone, in Proceedings The Third AusIMM International Geometallurgy Conference (GeoMet) 2016, pp 267–274 (The Australasian Institute of Mining and Metallurgy: Melbourne)."

Jun 15, 2016

By A. E. Cameron

The curve of coal production in Nova Scotia over the past forty years shows a definite maximum reached in 1913. Continued production to this maximum will require a greater tonnage per man-day, and this means there cannot be any increase in total man power used in the operations. There are still large reserves of coal but much of it will require washing or beneficiating to make a usable product. By-product recovery based on the present product ion is relatively satisfactory. Further development of secondary industries requires adequate markets for the bulk materials produced by the processing. It also requires access to other raw materials as well as markets for the principal product of the operations. Scientific investigation and research are needed to prove the quantity and value of lower grade or poorer quality coals, and methods for their recovery and utilization. Economics of further processing of present and future production must be investigated beforehand, if a successful development is to be assured. Such development cannot be expected largely to replace present markets. Production of coal for genera l use must continue to form the major function of the coal industry of the Province. Costs per ton must decrease, or subsidies or other assistance must increase, if the industry is to survive. Costs of investigation and research and costs of capital outlay for further development muse be met.

Jan 1, 1944

By M Sykes

Gold was initially discovered at Ballarat in 1851. After initial alluvial mining, underground quartz mining commenced in 1853, continuing until 1918. The historic miners were considered to be capable of mining anywhere in the world after overcoming the difficult conditions within the Ballarat goldfields. Whilst mining has changed dramatically since the early 1900s the challenges with underground mining at Ballarat have not. Modern pumping systems cope with the moderate water inflows. However, modern machinery and efficient mining methods influence opening sizes and extraction techniques. In some cases modern techniques have accentuated the challenging ground conditions and complex orebodies that were faced by the historic miners. As the Ballarat East project has progressed towards production, technical challenges relating to geomechanics and mine planning are being resolved resourcefully.

Jan 1, 2008

By D. L. Yopps

In research conducted by the U.S. Bureau of Mines, platinum-group metal (PGM) flotation concentrate from the Stillwater Complex, MT, was subjected to biooxidation using Thiobacillus ferrooxidans in an effort to break down the sulfide minerals and liberate the associated PGM's for subsequent chemical leaching. Bacterial preleaching oxidized up to 94 pct of the sulfide present, destroyed the PGM-bearing pentlandite [(Ni,Fe)9S8] mineralization, and dissolved most of the nickel in the concentrate. Cyanidation at 80° C proved to be the most attractive chemical leachant, removing 34 pct of the platinum, 76 pct of the palladium, 94 pct of the rhodium, and 97 pct of the gold from the biooxidized concentrate. Research also indicated that increased sulfide oxidation during the preleach phase led to improved PGM recovery in the subsequent chemical leaching phase.

Jan 1, 2010

By D. M. Lewis, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, J. H. Kang, V. Castronova

"Tetrandrine is a bisbenzylisoquinoline alkaloid which has been shown to exhibit antifibrotic activity against silicosis. Tetrandrine is characterized by its strong binding to alveolar macrophages and inhibition of particle-induced respiratory burst activity in these phagocytes. In contrast, tubocurine and tubocurarine are structurally similar to tetrandrine but exhibit little effect on fibrosis or activation of alveolar macrophages. The objective of the present study was to test the effect of tetrandrine on macrophage production of monokines in response to occupational dusts, and to determine tetrandrine's effect on monokine-medicated cell growth using a mouse thymocyte proliferation assay and lipopolysaccharide (LPS) as a positive control. Stimulation of alveolar macrophages by respirable silica dust resulted in a release of monokines which caused a fourfold increase in thymocyte proliferation. Coal dust, on the other hand, had no effect on macrophage production of this cytokine. Tetrandrine was found to exhibit a dose-dependent inhibition of monokine release from both silica and LPS-stimulated alveolar macrophages. In experiments where thymocytes were directly treated with tetrandrine, a dose-dependent inhibition of thymocyte proliferation was noted with both interleukin-1- (IL-1) specific and nonspecific mitogenic (concanavalin A) actions. In contrast to the inhibitory potency of tetrandrine, tubocurarine was found to have no effect on either the production of monokines by LPS-stimulated alveolar macrophages or IL-I-mediated thymocyte proliferation. These results provide a correlation between the ant:fibrotic effect of tetrandrine and inhibition of macrophage activation. INTRODUCTIONThe pathogenesis of chronic pulmonary fibrosis caused by inhalation of occupational dusts has been associated with abnormal activation of alveolar macrophages such as the release of various cytokines capable of inducing fibroblast proliferation and collagen synthesis. These macrophage-derived cytokines include interleukin-1 (IL-1), tumor necrosis factor (TNF), platelet-derived growth factor (PDGF), transforming growth factor-B (TGF-(B), macrophage derived growth factor (MDGF), and interferon [1, 2].Interleukin-1 is a major macrophage-derived cytokine that has been shown to exhibit multiple biological effects on a variety of target cells. It is known to cause leukocyte [3, 4] and endothelial cell activation [5, 6], and to affect the synthesis and maintenance of the extracellular matrix by stimulation of fibroblast proliferation [7-9], synthesis of collagens [10] and gluco-saminoglycans [11], and prostaglandin E2 production [12]. In addition, IL-1 plays an important role in the initiation of an immune response through its direct activation of lymphocytes and stimulation of the production of other cytokines, such as interferons and hemopoietic colony-stimulating factors, needed for the expression of an immune response [13]. As a major cytokine in the immune-inflammatory sequela, IL-1 is also produced by epidermal, epithelial, lymphoid, and vascular tissues after infection, injury, or antigenic challenge [14]. Agents such as lipopolysaccharide (LPS), phorbol myristate acetate (PMA), immune complexes, and particulates are known to activate the synthesis and release of IL-1 by monocytes and macrophages [15]. These substances also trigger intracellular signals leading to altered arachidonic acid metabolism. Although the mechanism is still not clear, prostaglandins have been shown to suppress IL-1 translation via the induction of cyclic adenosine-monophosphate (CAMP), whereas leukotrienes produce a positive signal for IL-1 production [13]."

Mar 1, 1992