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By N. S. Dalal, V. Castranova, K. Van Dyke, V. Vallyathan, J. H. Kang

"We have reported previously that crushing or grinding crystalline silica results in the generation of silica-based radicals on the particulate surface and that these radicals can generate hydroxyl radicals in aqueous solution. Data in the present study indicate that freshly ground silica is more cytotoxic and is a more potent activator of alveolar macrophages than comparably sized aged silica. That is, compared to aged silica, fresh silica is 4.2-fold more potent in decreasing the membrane integrity of macro· phages; is 50% more potent in activating hydrogen peroxide secretion by macro· phages; and is 4.frfold more potent in stimulating cellular chemiluminescence. Prosil 28, an organosilane material, is an effective coating agent for fresh silica. It decreases the cytotoxicity of fresh silica by as much as 78% and decreases the ability of fresh silica to induce chemiluminescence from alveolar macrophages by 58%. The data suggest that surface radicals associated with freshly cleaved dust may be an important factor in the induction of pulmonary disease. Furthermore, treating dust with coating agents may substantially decrease toxicity. INTRODUCTIONThe U.S. Department of Labor estimates that over 1.25 million American workers may be exposed to crystalline silica and that nearly 60,000 may be at risk of developing some degree of occupational lung disease (Parkes, 1982; Peters, 1986). Occupations of concern include miners, stone quarry workers, sand and gravel workers, sandblasters, foundry workers, and glass workers. Acute silicosis is characterized by inflammation, alveolar lipoproteinosis, and the rapid development of respiratory disability (Banks, 1986). In contrast, chronic silicosis develops 20-40 yr after initial exposure and is characterized by the appearance of concentric hyalinized nodular lesions and the progressive development of dyspnea (Parkes, 1982; Ziskind et al., 1976)."

Mar 1, 1992

By D. M. Lewis, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, J. H. Kang, V. Castronova

"Tetrandrine is a bisbenzylisoquinoline alkaloid which has been shown to exhibit antifibrotic activity against silicosis. Tetrandrine is characterized by its strong binding to alveolar macrophages and inhibition of particle-induced respiratory burst activity in these phagocytes. In contrast, tubocurine and tubocurarine are structurally similar to tetrandrine but exhibit little effect on fibrosis or activation of alveolar macrophages. The objective of the present study was to test the effect of tetrandrine on macrophage production of monokines in response to occupational dusts, and to determine tetrandrine's effect on monokine-medicated cell growth using a mouse thymocyte proliferation assay and lipopolysaccharide (LPS) as a positive control. Stimulation of alveolar macrophages by respirable silica dust resulted in a release of monokines which caused a fourfold increase in thymocyte proliferation. Coal dust, on the other hand, had no effect on macrophage production of this cytokine. Tetrandrine was found to exhibit a dose-dependent inhibition of monokine release from both silica and LPS-stimulated alveolar macrophages. In experiments where thymocytes were directly treated with tetrandrine, a dose-dependent inhibition of thymocyte proliferation was noted with both interleukin-1- (IL-1) specific and nonspecific mitogenic (concanavalin A) actions. In contrast to the inhibitory potency of tetrandrine, tubocurarine was found to have no effect on either the production of monokines by LPS-stimulated alveolar macrophages or IL-I-mediated thymocyte proliferation. These results provide a correlation between the ant:fibrotic effect of tetrandrine and inhibition of macrophage activation. INTRODUCTIONThe pathogenesis of chronic pulmonary fibrosis caused by inhalation of occupational dusts has been associated with abnormal activation of alveolar macrophages such as the release of various cytokines capable of inducing fibroblast proliferation and collagen synthesis. These macrophage-derived cytokines include interleukin-1 (IL-1), tumor necrosis factor (TNF), platelet-derived growth factor (PDGF), transforming growth factor-B (TGF-(B), macrophage derived growth factor (MDGF), and interferon [1, 2].Interleukin-1 is a major macrophage-derived cytokine that has been shown to exhibit multiple biological effects on a variety of target cells. It is known to cause leukocyte [3, 4] and endothelial cell activation [5, 6], and to affect the synthesis and maintenance of the extracellular matrix by stimulation of fibroblast proliferation [7-9], synthesis of collagens [10] and gluco-saminoglycans [11], and prostaglandin E2 production [12]. In addition, IL-1 plays an important role in the initiation of an immune response through its direct activation of lymphocytes and stimulation of the production of other cytokines, such as interferons and hemopoietic colony-stimulating factors, needed for the expression of an immune response [13]. As a major cytokine in the immune-inflammatory sequela, IL-1 is also produced by epidermal, epithelial, lymphoid, and vascular tissues after infection, injury, or antigenic challenge [14]. Agents such as lipopolysaccharide (LPS), phorbol myristate acetate (PMA), immune complexes, and particulates are known to activate the synthesis and release of IL-1 by monocytes and macrophages [15]. These substances also trigger intracellular signals leading to altered arachidonic acid metabolism. Although the mechanism is still not clear, prostaglandins have been shown to suppress IL-1 translation via the induction of cyclic adenosine-monophosphate (CAMP), whereas leukotrienes produce a positive signal for IL-1 production [13]."

Mar 1, 1992

By R. V. Ramani, R. Bhaskar

"An airborne dust cloud is an ensemble of particles of varied size, density, shape and states of aggregation. An understanding and quantifying of the dispersion and deposition of the du.st generated in mines is essential to the development of measures for reducing worker exposure to dust.In coal mining, the major portion of the dust is generated during the cutting of coal using a shearer or a continuous miner. The major phenomenon affecting ambient concentration is the deposition of dust. Panicle deposition may take place due to the effect of gravitational, inertial, electrostatic, and thermal forces, and mechanisms such as Brownian and eddy diffusion and inenial impaction. The three major mechanisms of deposition in turbulent flow in mines are diffusion (Brownian and eddy), sedimentation and inertial impaction. The mechanisms determining panicle deposition are size dependent.From a review of the literature, there appears to be a knowledge gap in the understanding of the deposition phenomena in mine airways. In order to obtain a better understanding of the deposition of dust for various particle sizes, and to develop a set of data for evaluating predictive mathematical models/or dust flow in mines, a series of dust-flow experiments was performed under controlled conditions in mine airways. It appears that the deposition data generally follow the theoretical behavior of dust based on the combined effect of diffusional and gravitational deposition. Jn this paper, the findings of the study on the deposition of dust in mine airways and its dependence on size, velocity and concentration are discussed. A set of deposition equations that could be used to determine the approximate deposition at various points in a mine airway are presented.IntroductionThe major factor affecting ambient dust concentration in mine airways is the deposition of dust. Particle deposition may take place due to the effect of gravitational, inenial, electrostatic, and thermal forces, and mechanisms such as Brownian diffusion, eddy diffusion and inertial impaction. The major mechanisms of deposition in turbulent flow in mines are diffusion (Brownian and eddy), sedimentation and inertial impaction. Inertial impaction is significant only during changes in direction, but the change in direction of flow with resultant powerful eddies may cause increased re-entrainment of the particles, thus having a compensating effect. While the literature in aerosol sciences contain several references on deposition, most studies were done in small diameter tubes for diffusional deposition (Liu and Agarwal, 1974). The deposition data from small diameter, short tube experiments may not be applicable to studying deposition in mine airways that have large areas and extend several hundred meters. Further, the change in concentration along the length of a mine airway may significantly affect the deposition an aspect that may not be easily determined in short tubes in laboratory experiments."

Mar 1, 1992

By N. S. Dalal, B. Jafari, F. H. Y. Green, M. Petersen, V. Vallyathan

"Stable coal radicals (SCRs) were detected by electron spin resonance (ESR) spectroscopy in the lung tissue of autopsied coal miners. The SCR concentrations were measured in the lung tissues from 98 coal miners with and without (a) coal workers' pneumoconiosis (CWP), (b) cancer, and (c) a history of cigarette smoking. Concentrations of SCRs were also determined in the lungs of nonminer controls. The SCR concentration was related to longer mining tenure, CWP disease severity, lung cancer, and cigarette smoking. The mean concentration of SCRs in the lung tissues of miners with 30 ± 1.4 y of coal mining exposure was 5.3 ± 1.3 x 10"" spins/g versus controls who had a nondetec¬table level (< 10 15 spins/g). An increase in disease severity was accompanied by a progressive increase in SCR concentration. A SCR concentration of 4.8 ± 0.7 x 10"" spins/g was found for simple CWP (with moderate coal macules) versus 7.8 ± 4.6 spins/g lung tissue for complicated CWP (with progressive massive fibrosis). Significantly higher (i.e., 10 x 10"") concentrations of SCR in the coal miners' lung tissues were associated with an exposure history in the anthracite regions of northeastern Pennsylvania. These results in¬dicate a possible role for SCRs in the disease process. Furthermore, ESR appears to be an adequate methodology for the quantitation of coal dust retained in the lung and for distinguishing exposures to anthracite and/or bituminous coal.THE PREVALENCE AND SEVERITY of coal workers' pneumoconiosis (CWP) differ markedly between geographic locations, mines, and coal fields irrespective of comparable levels of exposure to coal mine dust These differences cannot be fully explained by the presence of silica and other minerals in the coal mine dust.' Rank of coal is also an important factor in the pathogenesis of CWP. Equally important is that the prevalence of CWP decreases from east to west in the United States,' and South Wales miners develop more severe CWP than miners in Scotland.' However, there are conflicting reports that cast uncertainty on the influence of rank of coal in the development of CWP."" These problems are complicated but will be solved as new technology emerges and as more is learned about the disease process."

Mar 1, 1992

By D. V. Venugopal, W. W. Gardiner

Spessartine-quartz rocks are manganiferous sedimentary rocks rich in spessartine and quartz which occur in north-central New Brunswick. They represent a recrystallised manganiferous siltstone/chert that is contained in or associated with red manganiferous siltstone (RMS) units. The spessartine-quartz rocks and RMS form part of an Ordovician volcanic and sedimentary succession within the Appalachian-Caledonian orogen which hosts numerous massive sulphides and polymetallic vein deposits. The New Brunswick spessartine-quartz rocks are spatially and temporally associated with stratiform base-metal, precious metal and hydrothermal tin-tungsten deposits. This suggests that spessartine-bearing lithologies and zones can be useful in predictive metallogeny and for the understanding of the stratigraphy and palaeographic setting of the early Palaeozoic rocks of the Appalachian-Caledonian orogen.

Jan 12, 1992

By J. Ostwald, L. T. Matthews, C. E. Loo

Australia has large reserves of pisolitic limonite. Mining recently commenced on the Yandicoogina deposit to produce a high-grade sintering ore. The ore contains about 10 wt% combined water and simulated sintering temperature profiles indicate that progressive dehydration of ore particles occurs in the temperature range 300-700 degrees C. Studies by optical microscopy show that although the dehyrdrated ore particles contain numerous cracks, there is no change in the microstructure of the ore because topotactic transformation to haematite results in the formation of compact masses of very fine-grained haematite microcrysts. When the ore is held at around 1 200 degrees C for 1 min significant recrystallisation of these microcrysts occurs, resulting in the formation of optically visible, micrometre sized haematite crystallites. Studies to simulate the behaviour of ore particles during sintering (as nuclear particles surrounded by a standard adhering fines mixture) show that the recrystallisation process occurs much earlier at temperatures of about 900 degrees C. Further studies indicate that CaO in the adhering fines mixture enhances the recrystallisation of the ore nuclei. The results of the investigation indicate that the pseudo-relict haematite in sinters produced from ore blends that contain significant levels of pisolitic limonite consists of dehydrated goethite that has undergone significant recrystallisation and grain growth, a phenomenon that is facilitated by the presence of lime derived from the sintering melt.

Jan 12, 1992

By F. Boudreault, M. J. Scobie, J. Szymanski, C. Hendricks

The development of new stoping methods and more effective control over dilution, recovery and fragmentation depends on improved accuracy in blasthole drilling. The mechanisms and factors which control accuracy are poorly understood. Canadian blasthole stoping and the practices adopted for monitoring and controlling drilling accuracy are reviewed. The techniques and problems associated with blashole set-up and trajectory surveying are discussed. Four new blasthole trajectory survey systems are evaluated on the basis of their performance in recent underground trials. Conclusions are drawn as to the technological developments required so that more precise control over drilling accuracy can be achieved.

Jan 12, 1992

By L. J. Barnes, R. O. Koch, J. H. Versteegh, C. J. N. Buisman, P. J. H. Scheeren

Several water treatment options have been studied and piloted. A process based on activity of sulphate reducing bacteria combines sulphate removal and heavy metal removal in one process step. The anaerobic bacteria reduce the sulphate to sulphide and consequently metal sulphides will precipitate. The final design for the commercial scale plant is described.

Jan 12, 1992

By NA NA

Reports of discussion at sessions held in Keyworth, UK, on 22-23 April 1992.

Jan 12, 1992

By L. J. Barnes, R. O. Koch, J. H. Versteegh, P. J. H. Scheeren, F. J. Janssen

Following two years of laboratory research with bench scale reactors, a 9 m3 experimental process demonstration reactor was installed at Budelco's zinc refinery to treat their underlying groundwater. A 600-fold scale-up was successfully achieved. It has demonstrated that this anaerobic microbial process can remove a wide range of heavy metals and sulphate to the required levels. Extended operation of the demonstration unit has shown that the process is robust, can withstand wide variations in feed composition, rapidly recovers from operational upsets and is easy to start up and shut down. The metal sludge produced can be processed in a metal refinery to recover both metals and sulphur.

Jan 12, 1992

By International geochemical

During the production of the Geochemical Atlas of Finland till samples were collected throughout Finland at a density of one sample per 300 km2. The material studied was the fine fraction of till (less than 0.06 mm). The geochemical mapping has shown that elements that are locally enriched in bedrock in the form of ore mineralisation are also enriched in a wide area of the surrounding till. These anomalous enrichments of ore elements take the form of rectangular or curvilinear zones that are some tens of kilometres wide and hundreds of kilometres long. The mineralised zones host ore deposits of different genetic types and can be termed "ore provinces". They stand out prominently on the geochemical maps and can be divided into sub-units of different chemical composition.

Jan 12, 1992

By R. Vikram

IMAGES (Integrated Mapping Applications Graphical Evaluation System) is a computer graphics system developed by British Coal for mine planning. The objectives of the system are to increase the profitability of mined coal through a combination of direct and indirect benefits. The system is flexible and can be used in part or in full at a mine as a stand-alone system or as a remote location of a central corporate system.

Jan 12, 1992

By D. J. Buchanan

British Coal's mining research programme is directed towards the strategic objectives of reducing production costs, improving product quality and resolving health, safety and environmental issues. The strategy for R&D is described and selected parts of the programme are reviewed. Two major initiatives are directed towards reducing production costs: geotechnics and automation. Integrated exploration techniques are used to delineate geological structures as an aid to mine planning. Rockbolting is being rapidly introduced and the in situ stress field has been found to be of significant influence. Automation is the subject of a major programme. A strategy for coal quality has been devised. The health, safety and environmental programme concentrates on the traditional hazards together with surface environmental problems.

Jan 12, 1992

By M. J. Russell, W. E. Stephens, D. B. Mohamad, A. B. MacKenzie

Redox front processes in rocks are important in the context of both radioactive waste disposal and the development of orebodies. Results are presented from a study of the distribution of uranium and thorium and the natural decay series equilibrium about redox fronts in a granite at the Criffel pluton and Craignair quarry, Dalbeattie in southwest Scotland. The results are considered in the context of large scale uranium aqueous transport in the region and compared with those from a previous study of highly developed redox fronts at Pocos de Caldas, Brazil. Results show that the Criffel pluton has experienced a recent and rapid removal of uranium from the uppermost section of the granite whereas thorium has remained relatively immobile. The radium and uranium distributions indicate that diffusion processes probably control the distribution of radionuclides about the front. These processes are similar to those observed at Pocos de Caldas. The trends of concentration and activity ratio about the Dalbeattie redox front are less pronounced than those at Pocos de Caldas owing to the shorter time available for the process and the lower intensity of weathering at Dalbeattie.

Jan 12, 1992

By G. B. Hooper, G. A. Ferguson

The technical capabilities and user-friendliness of the major computer-aided mining design software systems are reviewed. Recent experiences with three systems are outlined to indicate the practical problems that arise. The examples were: Microlynx software from Lynx Geosystems at the Great Dyke platinum mine in Zimbabwe; Lynx software from Lynx Geosystems at a copper mine in central Africa; and PC-MINE software from Gemcom Services at an open-pit gold project in Western Australia. Difficulties in the use of mining design software has led to an alternative approach. Falconbridge, Canada, has developed an integrated mine-planning system on a CAD platform that encompasses ore reserve estimation, stope design, development layout and survey control. Future directions of computer-aided mining design using this basis are discussed. A major advantage of using mainstream software packages, such as spreadsheets, databases and CAD programs, is that most engineers and geologists are experienced in handling such systems in the normal course of their work.

Jan 12, 1992

By Mohammed Ali Shah, Martin Waller

The mining industry depends to a large extent on the availability of high performance equipment. For drilling this means a requirement for well engineered, reliable machines with mechanised handling and widespread utilisation of automatic control. Such machines enable performance optimisation of drilling operations and integration into a high productivity mining system. A review is presented of the current status of drilling technology as applied to the mining and minerals industry. This covers developments in: drill bit materials and design; drilling techniques; machine design; mechanisation; automation; and drilling control. It also covers the ways in which current and future mining methods and practices will influence the applications and demands placed on drilling activities. The probable impact of current research on the industry is discussed.

Jan 12, 1992

By P. Danson, D. A. White, S. Bashir

Composite ion exchange materials made of SnO2, TiO2 and MnO2 can be used to remove radioactive contaminants from nuclear waste streams. In several cases their selectivity and capacity are enhanced by mixing hydrous silica into the matrix. MnO2-SiO2 materials are especially useful for a number of reasons, such as their selection of heavy elements over caesium. Distribution constants and determinations of exchange capacities show that in many instances the properties of the composites are better than those of the oxides alone, while the presence of a chelating agent has been found to reduce the uptake of nuclides considerably. Methods are being developed for the bulk manufacture of the materials. Further work on sorption mechanisms is required to explain anomalous results, particularly the variation in exchange capacity for different elements and the ability of the oxides to sorb colloidal material in alkaline solution.

Jan 8, 1992

By I. A. Scott, T. J. Napier-Munn

Size-by-size partition curves for mineral separation in dense-medium cyclones pivot about a single characteristic point. This is defined for stable, non-segregating media by the medium density and the proportion of the medium reporting to the underflow. The pivot point departs from these values for unstable, conventional media. The phenomenon can be represented by an equation with two parameters defining pivot point coordinates and two the Ep value. On the basis of experiments in a 200 mm cyclone using ferrosilicon media, simple regression equations were developed for the separation parameters in terms of operating conditions (the coefficients were likely to be site-specific). The experiments successfully decoupled the effects of medium density and viscosity and showed that the value of Ep was independent of the former but strongly dependent on the latter. A classification model was used to predict the density of the underflow medium, a knowledge of which is required to determine the pivot parameters. The model correctly reflects the performance trends observed in dense-medium cyclone operation and has the potential to be generalised to a wide range of industrial practice.

Jan 8, 1992

By M. Thompson, B. Coles, M. Hale

The use in regional geochemical reconnaissance of replicate analysis of natural coatings of iron and manganese oxides on the surface of pebbles in stream sediment is described. Pebble coatings were selectively analysed for their relative contents of absorbed trace elements by ablating a small quantity of the coating with a laser beam and sweeping the aerosol obtained into an inductively coupled plasma atomic emission spectrometer. Using this procedure, a geochemical survey in northwest Wales revealed anomalous concentrations of Cu, Mo, As, Zn, Cd, Pb and Co in the pebble coatings of streams draining the mineralised Coed-y-Brenin diorite and the Dolgellau gold belt.

Jan 4, 1992

By R. G. Siddall, W. Gale

In the UK the development of the science of strata control has been strengthened by a resurgence of interest in the specialism of roofbolting and its associated techniques. The evolution of the theories and practices of strata bolting in roadway stabilisation is discussed. Practical experiences are considered, principally the use of Australian techniques, the relationship between bond strength and annulus and the effects of stress in the ground. Areas of new technology such as cable bolting, injection anchors and on-board bolters are also discussed. The recent advances in computer technology and rock testing equipment and methods have provided the opportunity to simulate ground behaviour under various conditions. Computer modelling developments and the use of techniques to predict ground behaviour are described.

Jan 4, 1992