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By R. L. Pearson

The 1987-88 Denver Brown Cloud Study was performed to determine the sources of the particle cloud which forms over Denver each winter. The study was organized under the leadership of Colorado Governor Roy Romer , EPA Region VIII and the Greater Denver Chamber of Commerce. The study was sponsored by over 40 organizations representing governmental agencies, the natural gas industry, the coal industry, utilities, oil companies, railroads, the motor vehicle industry, and other Denver area companies and organizations. The cost of the study was $1.5 million which was raised almost entirely from private sources. The study team was headed by Dr. John Watson of the Desert Research Institute of the University of Nevada. Dr. Watson is a recognized expert in conducting studies of this type.

Jan 1, 1990

By Steve Kral

Despite low commodity prices and mining industry cutbacks throughout the world, Peru remains one of the industry’s bright spots. The country’s remarkable economic turnaround during the 1990s remains a model for other developing nations to follow. And the Peruvian government has not forgotten the industry that was instrumental in that turnaround. True, the country has not been spared the effects of the mining industry’s retrenchment that has occurred in other parts of the world. However, foreign mining companies remain committed to doing business in Peru. And the government remains committed to attracting foreign investment and maintaining a strong mining industry. This commitment was evident in September 1999during the 24th Convention of the Institutos de Ingenieros de Minas del Peru in Arequipa, Peru. More than 3,000 mining industry professionals from around the world attended the convention. And Extemin, the accompanying exhibit, featured more than 450 companies, many from the United States, Canada, Australia, South Africa and other countries.

Jan 1, 2000

By A. Carbonari

In order to gain competitiveness and compete at a global level, construction companies should improve their efficiency. The problem is even more relevant in the construction field, whose work processes find it hard to evolve towards new automated methods and techniques in the management field. For that reason, this paper suggests how construction companies could apply new technologies to implement automated management of environmental hazards. Based on a survey regarding the environmental risks presently experienced in construction sites, noise and dust were considered two of the main hazards. So in this paper a networked system for real time remote monitoring of the spatial distribution of dust in construction sites was developed. Such a system would relieve builders from the commitment of on-site surveys, allowing for a continuous monitoring of the site conditions and of the real exposure of each worker and pass-by to the pollutants generated by construction works. The main system requirements considered are: easy to deploy, reliable, as accurate as needed to be able to send real-time warnings and store a good estimation of the real exposure to which involved people have been subject to. So far the research produced a prototypical hardware for dust monitoring made up of wireless sensors which can be easily deployed on site. The sensors were calibrated by means of laboratory tests, where their measurements were compared with those collected by means of highly accurate instruments, which were taken as a reference. Thanks to these experiments, calibration curves for the sensors were worked out, showing also the measurement range of the sensors.

Aug 1, 2013

The problem of comparison of island arc's andesites in terms of petrochemical data is exa- mined. It is definitely established that only two main factors exist controlling the petroche- mical variety of the Kurile arc's andesites.Ori final multivariate statistical technique and computer software are used to extract these fac- tors. It is shown as well that the chemical com- position of igneous rocks depends on the type and structure of the Earth's crust. The follo- ~cing interpretation is proposed for the two factors describing petrochemistry of andesites: the first one is the depth to the Benioff seis- mofocal zone and the second one is supposed to indicate the position of the peripheral magma chambers. The basic trends of variations in the chemical composition components depending on the changes in the controlling factors are de- Tcnnined.

Jan 1, 1987

By M. Piboule et J. M . Charbonneau, C. Picard

In the western part of the Chapais syncline (Abitibi-east, Quebec), the lava flows belonging to the Haliy Formation separate in two distinct sequences. The basal sequence contains prophyri tic metabasalts of calc-alkaline af f inity overlain by porphyritic metatrachyandesites and metatrachytes of alkaline to shoshonitic affinity. The upper sequence contains porphyritic metabasalts similar to those of the basal sequence along with highly potassic metaandesites trending to a subalkaline affinity. A geochemical study of trace and REE elements established that the composition of these lava flows results from a mixing or contamination process. The primitive tholeiitic liquids which are enriched in LREE were modified by the addition of a crustal contaminant enriched in Y, Zr, Th and K20. The magmatic liquids resulted from successive steps in the admixing process, evolved by fractionated crystallization. The mechanism of gradual admixing seems to be the major cause of the observed ea le-alkaline characteris ties and may also be the cause of the alkaline to shoshoni tic affinity in those lavas. The tendency to differentiation by fractional crystallization reveals the tholeiitic character of the primitive liquids.

Jan 1, 1984

By L. D. Snyder, J. K. Russell

"The Lower Jurassic Iron Mask batholith intrudes Upper Triassic Nicola Group volcanic rocks in the Quesnellia terrane of southcentral British Columbia and hosts Cu-Au mineralization. The batholith comprises three mappable intrusive phases, including: Pothook gabbro to diorite, Cherry Creek monzodiorite to monzonite and Sugarloaf diorite. The Iron Mask hybrid forms a fourth mappable unit that makes up to 45% of the areal exposure in the batholith. It is highly variable in texture and composition and subdivided into three types; Type I and II have abundant (partially digested) xenoliths, many of which are derived from the Nicola Group, whereas Type III is xenolith-poor and shows extreme outcrop-scale textural diversity.Pothook and Cherry Creek rocks are similar in texture, mineralogy, whole rock and mineral composition and style of alteration. Contacts between the two can be intrusive or gradational. Rocks collected from these two suites have compositions that are permissive of a single magma batch, although simple crystal fractionation does not explain all chemical variations within and between the two suites. The Sugarloaf unit comprises a diverse group of amphibole-phyric rock types and is texturally and mineralogically distinct from Pothook and Cherry Creek suites.The Iron Mask hybrid represents progressive stages of physical and chemical interaction between Nicola Group country rocks and Pothook magma. Magmatic assimilation (selective or partial) is supparted on the basis of field relationships, petrographic observations, and REB compositional data. Thermal dehydration and partial assimilation of Nicola Group rocks by Pothook magma is shown to be a valid means of promoting early and extensive volatile saturation in the Iron Mask batholith."

Jan 1, 1995

By N. B. Aughenbaugh

A study was made to determine those petrographic parameters that are correlative with carbonate-aggregate quality as indicated by the Los Angeles abrasion and absorption tests. Samples collected at 28 sites in northern and eastern Indiana were analyzed petrographically, chiefly for void content, grain size, grain-size variation, grain shape, and grain interlock. Most of the sampled sites are in the belt of Silurian rocks of east-central and north- western Indiana. Though a few sites lie outside this belt, most of these have only a thin Devonian section above the Silurian. Three sites are non-Silurian and are included for comparison. Most of the samples studied are from Middle and Upper Silurian units. Both biohermal and nonbiohermal facies are included. The biohermal rocks are typically dense but vugular, finely crystalline granular dolomite. Nonbiohermal facies are porous, medium to coarsely crystalline, granular dolomite with dolomite rhombs The Los Angeles abrasion losses ranged from 20 to 46 per cent, the rocks in the eastern part of the state showing the higher values. Absorption tests indicate the same general quality trend. Comparison of petrographic studies with Los Angeles abrasion- and absorption-test results indicate the following correlations. (1) As per, cent of voids increases, quality decreases. (2) As average grain size increases, quality decreases. (3) Variations from mean grain size appear to have no effect on the quality. (4) As angularity and roughness of the grains increase, quality increases. (5) As grain-to-grain interlock increases, quality increases. Variations in the calcium-magnesium ratio have no apparent effect on aggregate quality, except as they affect the texture.

Jan 1, 1966

By D Craw, P V. Angus

Gold mineralisation at Macraes occurs as late quartz-carbonate veins within a body of sheared and hydrothermally altered Otago Schist, the Intrashear Schist. The alteration is characterised by the presence of rutile and the absence of epidote and titanite, indicative of an alteration fluid containing >10 mol per cent CO2. In areas of high strain, a fabric of black microshears develops, gradational to mylonitic cataclasite in the high strain zone adjacent to the hanging wall of the duplex shear zone. The microshears contain hydrothermal graphite, inferred to have been deposited from a methane-rich fluid. The mylonitic cataclasite is characterised by abundant pyrite, the absence of albite and extreme grain size reduction. Gold recovery in the CIL processing plant at Macraes can drop to 50 per cent or lower for some unfavourable ore types. Preg-robbing by a component in the ore, possibly graphite, was suspected as the cause. Mylonitic cataclasite was identified as the lithology responsible for the poor recoveries, with the capacity to bind about 30 ppm of gold in the leach tanks. A program of detailed geochemistry and quantitative grain-size measurement using Coulter analysis was undertaken to identify specific mineralogical factors associated with preg-robbing. The results indicate that pyrite, graphite, and extreme grain-size reduction are the factors associated with highly preg-robbing ores at Macraes. The evolution of the mylonitic cataclasite is accompanied by strong potassium enrichment, as muscovite, and depletion in sodium as albite is removed. This suggests that a simple powder XRD ratio of the albite to illite peaks would suffice to distinguish the preg-robbing ore for grade-control purposes.

Jan 1, 1999

By Li Shibo, C. Halls

The compositions of olivine, pyroxene and chromite from the Proterozoic ultramafic complex are analagous to those of cumulate ultramafic rocks of tholeiitic origin, suggesting that the parent magma may have been tholeiitic rather than komatiitic. The complex contains economically significant Ni-Cu sulphide mineralisation. The high sulphide/silicate ratio is best explained in terms of the segregation of sulphides from a large volume of magma, of which all but the ultramafic cumulate fraction has since been eroded. Platinum-group minerals that have been identified include sperrylite, moncheite, native platinum, froodite, merenskyite, michenerite and Pd-rich pentlandite lamellae exsolved from pyrrhotite. They are characteristically found in close association with chalcopyrite, either along the contacts between hydrosilicate and sulphide grains or in cracks within pentlandite and chalcopyrite, which may also be intergrown with galena. Crystallisation from a Cu-rich residual magmatic liquid also enriched in Pt, Pd, As, Sb, Bi, Te, Zn and Pb is postulated.

Jan 12, 1993

By Unkown

The Province-wide road ban on movement of heavy loads has had the effect of curtailing or stopping development in several areas. In the Leduc area, the discovery well has been restricted in flow to only a fraction of normal due to limited storage space, but drilling at Imperial Leduc Nos. 2, 3, and 4 has been continued for the past few weeks. The No. 2 well is within 100 feet of the producing horizon and should be completed within the next few days. According to reports, it has been logging slightly lower, structurally, than the discovery well, but, regardless of the outcome, it has been an important test to determine westerly cross-section of the Leduc structure. No official reports have been made available of any tests made during the drilling of the well, but it is understood that promising oil and gas shows have been indicated in higher formations. Actual drilling operations have not been commenced by any of the other companies holding leases in the immediate area but it is expected that, when road bans are removed and equipment is assured, several wells will be commenced. Announcement has been made that Imperial Oil, Limited, will drill a well near Battle lake, about thirty-five miles southwest of the Leduc field. Location of the well has been made following an extensive seismograph survey of the area, with total depth of the test well expected to be in the 8,000- to 8,500-foot range. Drilling will be done with the heavy-duty rig last used at the De Winton test. Imperial Oil have abandoned hope of oil production in the Provost area after drilling nine wells, but will retain their interest in the gas field that has been developed. Of the wells drilled, four indicated gas flows ranging from 1,060 to 13,200 M.c.f. per day.

Jan 1, 1947

By Ralph H. Espach

Wyoming contains many petroleum and natural-gas fields, and more than 250 geological structures have been mapped; however, only about 85 have been found (July 1938) to contain petroleum or natural gas, or both, in commercial quantities. To January 1938 approximately 434 million barrels of oil and 915 billion cubic feet of gas have been produced, and it was estimated that proved oil reserves in Wyoming amounted to 300 million barrels.' The Salt Creek field, the largest in the Rocky Mountain area, alone has produced 64 percent of the State's oil and 46 percent of its gas. This field ranked thirteenth among the producing fields of the United States in total cumulative production as of January 1, 1938. On this basis it ranks with the Kern River and Huntington Beach fields of California and the Butler County fields of Kansas. The Salt Creek field has declined in relative importance; in 1937, while still the largest oil-producing field in the State, it produced 31 percent of the oil and 11 percent of the gas extracted from all wells in Wyoming.

Jan 1, 1941

By C. A. Fisher

THE advent of the Rocky Mountain States into prominence as an oil-producing region is comparatively recent. Scarcely more than a decade has passed since the number of producing oilfields in this part of the country were few and their combined yield small and relatively unimportant. However, oil was discovered and recorded near the present site of Lander, Wyo., as early as 1833 and in 1867, on the comple-tion of the Union Pacific R. R., the site of this oil discovery was located, among other things, as a natural resource of economic importance. In that year a well was drilled for oil, to a depth of 480 ft., near Evanston, Wyo., but later was abandoned. In 1883, the Lander district witnessed the successful completion of the first oil well in the state. In Colorado, oil was first produced from shallow open wells near Canon City and sold to prospectors in 1864; in 1887, the Florence oilfield was discovered and a commercial production developed. While the Rocky Mountain States have never gained the prominence as an oil-producing region attained by the Pacific Coast, Mid-Continent, or Gulf fields, a substantial and increasing production is being taken from the Rocky Mountain province. At the close of 1923, the oil industry in this region has 38 oil and 21 gas fields producing, or capable of producing, oil or gas in a commercial way with a combined annual yield of nearly 47,000,000 bbl. of oil, a daily refining capacity aggregating about 90,000 bbl., upwards of 17,000,000 bbl. of crude in storage, and an 8-in. pipeline, nearing completion, 600 miles long which will connect the most prolific oilfield of the Rocky Mountain States with a trunk pipeline between Mid-Continent and the east at Carrollton, Mo. Several of the larger standard and independent operating companies are now represented in this region and, in the last ten years, there has been developed at Casper one of the large refining centers of the west. Fig. 1 illustrates the rise in production of four of the larger fields, also in the total production of the state; in addition there is given the yield of the larger fields of Wyoming and Montana for 1923.

Jan 3, 1924

By O. C. Wheeler

In order that the series of reports on oil and gas in Colombia may be complete, the report for the year 1941, which was not available for Volume 160 of the TRANSACTIONS, is given here. The report for 1945 begins on page 4o6.

Jan 1, 1946

By D. B. Williams

The end of the war in Europe and the Pacific failed to curb the upward trend of production in Venezuela,- which easily surpassed that of any previous year. The total production for 1945 amounted- to 323,369, 430 bbl., which was 26 per cent over the total for 1944, the previous peak in the history of the oil industry of the country. This increase was caused mainly by the greater demand for petroleum in the last stages of the war; the fact that the danger from enemy submarines had been overcome, which allowed all oil companies to use increased shipping facilities, and the fact that more materials were available for drilling operations. However, the materials supplied were by no means adequate and considerable credit is reflected on the Venezuelan petroleum industry for the increased production obtained by utilizing all available equipment to its fullest extent.

Jan 1, 1946

By Donald J. MacNeil

THE opinion, based upon geological knowledge, that certain areas within the Province of Nova Scotia might yield commercial quantities of petroleum, is not new. It dates back to at least 1864, when the Pioneer Oil and Salt Company drilled some shallow holes in search of oil near lake Ainslie, Cape Breton. As a matter of fact, several companies were engaged in oil exploratory work near lake Ainslie at about that time; included among them were the Inverness Oil and Mining Company, the Victoria Oil Company, the American Oil Company, and the Cape Breton Oil and Mining Company. Oil exploration by these and other companies was conducted sporadically on Cape Breton island until 1914. In several instances, the depth of the test holes exceeded 1,000 feet; the deepest was carried to 3,260 feet. The Lake Ainslie area was selected because oil seepages were present along certain sections of the lake shore, but the tests that were drilled to tap the oil-bearing zone failed to yield anything of commercial value. Currently, there are three areas in Nova Scotia wherein active exploratory work is being conducted, namely, at Pugsley Siding close to Amherst; at Kennetcook, Hants county; and near Mabou, Inverness county. The Pugsley Siding test is being drilled by the Sun Oil Company, of Philadelphia; the work at Kennetcook is under the direction of the Nova Scotia Oil and Gas Company; two relatively deep holes were drilled by the Lion Oil Refining Company in 1944 near Mabou, and, as a result of the additional geological information derived therefrom, another test probably will be drilled by this Company in the same area. Aside from these activities in the search for petroleum, the oil possibilities of several other sections of the Province are being studied by means of surface geological mapping.

Jan 1, 1945

By J. S. Stewart

THE Mackenzie River Valley proper extends from Great Slave lake to the Arctic ocean (see map, Figure 1). From Fort Providence, near Great Slave lake, to Aklavik, near the Arctic coast, the distance by river is 1,000 miles. This will give some idea of the extent of the region. Throughout the length of the river valley, the Precambrian complex rocks are overlain by unaltered sedimentary rocks several thousand feet in thickness. These sediments are dominantly marine and Palaeozoic in age. In places, the Palaeozoic strata are overlain unconformable by Cretaceous an Tertiary sediments. The strata have been folded and, in general, the inclination of the beds to the horizontal is comparatively gentle. Here, then, we have the essentials for potential oil fields covering an area over 1,000 miles in length. This is probably the largest comparatively unexplored potential petroleum region in North America, and surface evidences of oil in the form of seepages occur in several places. Many of these seeps were known to the early explorers, and the first Geological Survey report on the Mackenzie River region, containing the results of field work carried out by R. G. McConnell in 1887-88, noted the petroliferous character of the Devonian strata and the indications of petroleum(l). This region is, however, handicapped by distance from markets and sources of supply of materials; by lack of modern transport facilities; by short season for river transport, and mountainous country separating the valley from the Pacific seaboard; and by the long winter season with weather that makes outdoor work difficult. These factors have tended to discourage the enthusiasm of would-be promoters, and so development in this region has been slow In 1920, a test well drilled about fifty miles northwest of Fort Norman discovered oil in commercial quantity, and three additional wells proved a small area to be productive.

Jan 1, 1944

By Laszlo Imreh, Pierre Trudel, André C. Tessier

"The Siscoe gold mine is ranked as the fourth largest mine in the history of the Val d' Or mining district with a total production of 27.4 tAufrom1929 to 1949. Most of the gold mineralization occurred in quartz veins, hosted in a small (.69 km2) intrusion of altered quartz gabbro known as the Siscoe stock. The southern contact of the Siscoe stock is crosscut by a major shear zone (the ""K"" zone) trending 295/80 NE and from which gold mineralization was also exploited within the limits of the stock. Field and petrographic observations of the Siscoe stock combined with chemical analyses of major, trace and rare earth elements of the stock and its volcanic host rocks (Dubuisson Formation) suggest that:The Siscoe stock comprises four alteration facies formed from a homogeneous precursor: 1) the actinolite - Mg-chlorite facies, characterized by low FeOt,Na2O andTiO2 , and highAlp3 and MgO; 2) the albite- Fe-chlorite facies, containing high concentrations of FeOt and Nap; 3) the Mg + Fe-chloritefacies, which is transitional between the actinolite- Mg-chlorite and albite- Fe-chloritefacies; 4) the carbonate-chlorite facies, which consists of rocks that were subjected to extreme hydrothermal alteration, is spatially associated with mineralized veins and part of the K-zone. The first three facies are depleted in SiO 2, CaO and Au, and enriched in MgO, relative to fresh rocks of the Siscoe stock and the equivalent rocks of the Dubuisson Formation.Hydrothermal fluids introduced mainly along the K-zone ""channelway"" induced three types of element remobilization, resulting in the various alteration facies: 1) redistribution of elements within the stock from one facies to another (e .g., FeOt, Nap, Ti02 migrated from the actinolite- Mg-chlorite facies to the albite- F e-chlorite and Mg + Fe-chlorite facies); 2) remobilization of elements from the intrusive rocks into veins (e.g ., SiO 2 and CaO ); 3) introduction of elements by hydrothermal fluids in rocks of the Siscoe stock (e .g., Al2O3, MgO, H2O, CO2 and FeOt).The Siscoe stock and the Dubuisson Formation form part of the same tholeiitic suite. Similarly, the Bourlamaque batholith and the Val d'Or Formation belong to a single calc-alkaline suite. In view of this relationship, dissimilarities between the petrochemistry of the Siscoe stock and the Bourlamaque batholith suggest that the two intrusions are not co-magmatic.Finally, gold may have been leached from rocks of the Siscoe stock and remobilized into the quartz-carbonate mineralized veins. In order to account for the total production at the Siscoe mine, approximately 1.2 km3 of the Siscoe stock is thought to have been partially leached of its gold."

Jan 1, 1990

By R. J. Smyth

A Steel Compression Reinforcement Repair Technique (PetroSleevel) system has been developed that has the ability to repair pipeline defects such as stress corrosion cracking (SCC) without requiring welding to the operating pipeline. The Technology has been used to repair active cracking in ERW seam and cracking in the pipe body. All repairs were performed while the pipeline was in operation. This paper will discuss the engineering theory, testing performed to verify the engineering theory, and examples of actual sleeve installations.

Jan 1, 2005

By S. Deonarain, L. S. Schultz

"This paper details the process and methodology followed to rehabilitate a rectangular ventilation shaft, situated in the Free State region of the Witwatersrand Gold Fields in South Africa. The shaft consists of seven compartments where self-mining of the sidewalls had taken place and damage to the decayed steel work in the shaft had taken place, thus limiting access down the shaft. The paper will provide some insight into the successes and challenges encountered during the project and may provide some learnings for future projects of a similar nature. INTRODUCTION The ventilation shaft forms part of the Phakisa Mine, situated in the Welkom area of the Free State province of South Africa, and is located in the Southern part of the Witwatersrand Basin, one of the world’s largest known and richest gold deposits (Figure 1).As is typical in South African gold mines situated in the Witwatersrand basin, the shaft is 1 770 metres deep (below collar). The shaft was sunk during the early 1940’s and comprised a rectangular shape with 7 compartments, used for both rock hoisting and men and material winding, respectively, with a single lift “Mary-Anne” compartment. Early in 2003, the mine decided to change the shaft from a downcast hoisting shaft to an up-cast ventilation shaft. The conveyances, ropes, winders and headgear (head frame) were removed and replaced with a high volume fan delivering 323m³/s of air at a pressure of 4.2Pa on surface. The up-cast velocity in the shaft was 6.5m/s, however this reduced significantly with the scaling of the shaft and the restrictions at shaft bottom. Although Harmony had converted the shaft from a downcast service shaft to an up-cast ventilation shaft some years back, the shaft steel work in the barrel of the shaft was left intact. Over the years, the steelwork in the shaft had decayed (rust and grime) and portions of this steelwork fell down the shaft. Concurrent with the decaying steel work, portions of the shaft lining had collapsed and it was getting progressively worse."

Jan 1, 2019

By Ann Hubbs, Vincent Castranova, Jane Y. C. Ma, De-Hwa Chao, Joseph K. H. Ma

AN OVERVIEW OF THE ACTION OF TETRANDRINE ON SILICOSISBecause of the persistent presence of silica dust in the lungs silicosis is a progressive and irreversible disease. At present, there is no proven effective therapy for silicosis. Limited choices of therapeutic intervention with corticosteroids and other immunosuppressive regimens 1,2 have been accepted for some forms of pulmonary fibrosis. These treatments are only minimally effective, and the results provide little understanding of the disease state due to the lack of correlation between drug activity and the mechanism of fibrosis. Thus, continuing effort must be made in the search for effective antifibrotic agents, which may be used to provide a sequential analysis of the fibrotic process and to open the door for further research and clinical development. Tetrandrine is one of hundreds of drugs screened for antifibrotic activity by Chinese scientists. It has been used in China as a treatment for silicosis in open clinical trials3 and in laboratory animals. The action of tetrandrine on pulmonary fibrosis has been attributed to its ability to inhibit particle stimulation of alveolar macrophages, a key cell type central to the fibrotic process, to release oxygen radicals and inflammatory cytokines. Alveolar macrophages (AM) residing on the alveolar wall, are the predominant phagocytic cells of the lungs responsible for pulmonary defense against inhaled microorganisms and other particles and thus play an important role in maintaining the homeostasis of the lungs. 7 Ample evidence suggests that cells of the monocyte-macrophage series play an important role in the immunopathogenesis of pulmonary fibrosis. When upregulated by silica, alveolar macrophages generate reactive oxygen metabolites8·9 which can damage lung parenchyma and release fibrogenic growth factors and cytokines, 10,11 such as interleukin 1 (IL-1), which can induce fibroblast proliferation and collagen synthesis. The cytokine-mediated fibroblast proliferation and collagen synthesis are key steps in the development and progression of pulmonary fibrosis .11 Previous studies by our group have shown that tetrandrine exhibits strong binding affinity to AM and inhibits particle-stimulated respiratory burst activity (oxygen consumption, superoxide anion release, and hydrogen peroxide secretion) in these cells. 13 In addition, studies by Kang et al. 14 have reported that tetrandrine inhibits silica-induced release of fibrogenic factors such as IL-1 which are capable of inducing fibroblast proliferation and collagen synthesis. Reist et al. 15 further suggested that the antifibrotic action of tetrandrine may be mediated in part by the direct effect of this drug on the ability of fibroblasts to respond to proliferative agents. These results indicate that the mechanism of silicosis involves activation of AM and fibroblasts by silica, resulting in abnormal collagen production due to miscommunications between the cell types. Tetrandrine may interrupt this process by direct interaction with the lung cells.

Jan 1, 1998