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By P. Wearden, K. Bryner, K. Vrana, V. Castranova, R. Dey, R. Reist, J. Blackford

"Summary: Fibroblast proliferation and enhancement of collagen synthesis are key steps in the development and progression of pulmonary fibrosis. The current investigation presents a fibroblast proliferation assay to detect the release of competence factors from pneumocytes. The specific objective of this study was to define cell culture conditions for fibroblasts that would allow selective detection of competence factors in test media. The results indicate the following: (a) fibroblasts should be cultured for 2 days in plasma-free medium rather than 2% plasma to assure complete quiescence; (b) 1% plasma was optimum for producing progression activity for the bioassay of a competence factor, while 0.5% plasma did not produce sufficient progression activity (yielding false negatives) and 2% plasma often contained significant competence activity (yielding false positives); and (c) fresh plasma should be used since the progression activity of plasma was adversely affected by freezing and thawing. Under these conditions, this bioassay can be employed with either rat or human lung fibroblasts to detect competence factors such as platelet-derived growth factor (PDGF), at levels as low as 25 ng/ml.Fibrotic lung disease, as a consequence of occupational exposure to silica dust. is characterized by the development of concentric hyalinized nodular lesions in the lung and the progressive loss of pulmonary diffusion capacity. Proliferation of pulmonary fibroblasts and enhanced synthesis of collagen by these pneumocytes have been shown to be key steps in the development of chronic silicosis ( 1 ). The regulation of lung fibroblast proliferation by cytokines released from alveolar macrophages may be an important pathogenetic mechanism in the development of the fibrotic process (2). Some cytokines stimulate fibroblast proliferation by activating specific phases of the cell cycle (3,4). In particular, platelet-derived growth factor (PDGF) promotes fibroblast proliferation by inducing the movement of quiescent (G0 ) cells into the G1 phase of the cell cycle (5). Insulin-like growth factor (IGF) and transforming growth factor-P (TGF-P). on the other hand, regulate the rate of transition of fibroblasts from G 1 into the S phase (5,6). These two classes of cytokines have been termed competence and progression factors, respectively. One approach used to examine the release of cytokines from macrophages is the fibroblast proliferation assay in which quiescent fibroblasts are exposed to culture supematants from macrophages exposed to various stimuli. In most of these assays, the supernatant contains fetal calf serum (FCS), which provides the competence factor(s) necessary to facilitate the proliferation of fibroblasts (7-9). Recently, a fibroblast proliferation assay using platelet-poor .plasma [lacking competence factor(s)] as a substitute for FCS bas been described (I 0, 11 ). In this assay, the release of a competence-inducing PDGF-like growth factor from rat and human macrophages can be distinguished from other cytokines that act as progression factors."

Mar 1, 1992

By M Shaffer, D C. Grant, D J. Goudie, P Sylvester, C Voisey

Scanning electron microscope–Mineral Liberation Analyser SEM-MLA can be used to discriminate between hematite/magnetite in iron ores, but achieving backscattered electron (BSE) segmentation between the two minerals is difficult for particles =75 µm using typical preparation and analysis methods for the MLA based on a tungsten filament SEM (Quanta 400) with 25 kV high voltage. Preparing iron ore sample mounts using a slow-speed polishing method, and conducting the experiment on a field emission gun SEM-MLA (Quanta 650) with the high voltage (HV) setting lowered to 15 kV reduces instrument noise and results in very clean BSE images and segmentation. This method requires new X-ray standards to be acquired for each mineral identity at 15 kV because of major changes in the spectra at lower kV. However, once these X-rays are added to the mineral reference list, effective segmentation can be achieved and a proper analysis obtained.CITATION:Grant, D C, Goudie, D J, Voisey, C, Shaffer, M and Sylvester, P, 2017. Discriminating hematite/magnetite via scanning electron microscope–mineral liberation analyser in the - mesh size fraction of iron ores, in Proceedings Iron Ore 2017, pp 541–548 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Jul 24, 2017

By K Pery, J Leahy

Established metallurgical plants operate in a complex environment of interdependent drivers including technology change, operating and maintenance practice, evolving markets, HSEC requirements, statutory and plant requirements, personnel turnover, ore supply, and financial conditions, to name a few. A successful optimisation program should comprehend these factors and drive towards not only lower operating costs, but also higher rates of return for a given level of investment. Optimisation programs have the potential for very high rates of return on capital that Greenfield projects rarely have. This paper presents a robust strategy and methodology for plant optimisation initiatives as well as a case study of how it was implemented at the QNI Yabulu refinery in Queensland, Australia by an integrated team of researchers, engineers and operators. The methodology is premised on the fact that nobody knows the production asset as well as the current operating team. It covers the optimisation process from ideas generation, various stages of selection against the agreed criteria, development, including testwork, funding approval and implementation. It highlights the benefits in the use of integrated teams, the establishment of a sound project basis, and a diligent, phased approach.

Jan 1, 2004

A clear understanding of the meanings of terms is important when discussing a project. Whether it is a submission, an investment study, a feasibility study, an environmental impact statement, an estimate, a tender, a contract, or a close-out.report, the need for all parties involved to understand what is under discussion or what has been written is paramount. The clarity of definition and the level of understanding can affect the outcome of the project. It is vital that all parties know what is wanted, what is expected, and what it will cost. This paper draws attention to some of the problems that beset many projects, clients, project managers and contractors, and it is hoped that its presentation will encourage us to pay more attention to defining what it is that is required. Ultimately we should all be the richer for having defined and understood the requirements at the beginning rather than at the end.

Jan 1, 1990

By Hasan Ozturk

Laboratory testing examined the effect of a variety of intrinsic rock properties and environment conditions that influence the adhesive bond between rock and thin spray-on liners. The liner materials used for these tests were Tekflex, provided by Fosroc, Castonite, provided by Rohms and Haas Co., Rockweb provided by Spray-on Plastics, and CS 1251 2K, provided by Master Builders. Some of the variables examined include: rock strength (tensile/compressive strength) rock mineralogy, rock surface roughness (grain size, fracture/joint roughness), and surface contamination (oil, water or dust). Under optimal conditions, adhesive strengths reaching at least 3 MPa can be achieved. Where the rock surface is contaminated with dust or the rock is weak in tension, it may be difficult to reach adhesion strengths of 1 to 1.5 MPa.

May 1, 2004

By W. J. Young, K. B. Macneill, C. N. Smith

"A BRIEF HISTORY OF THE MURRAY BROOK MINERAL DEPOSITDuring the mid-1950's intensive exploration activity in northern New Brunswick followed the discovery of the world class Brunswick base metal deposit. Using the prototypes of modern airborne geophysical and geochemical exploration techniques many mineralized areas in the Bathurst-Newcastle area were quickly identified. This base metal - silver camp is situated within the metavolcanic - metasidementary rocks of the Tetagouche Group which forms a roughly circular caldera-chaped voloanio complex of Ordivician age.One of the early results in the exploration history in the camp was the discovery of the Murray Brook Deposit by Kennco Explorations, (Canada) Limited. During routine ground checking of geophysical anomalies, most of which turned out to be graphitic schist, the discovery of some copper bearing float was made by the exploration team. This encouraged the company sufficiently to carry out a regional stream sampling program which lead to a large anomaly associated with a hematitic gossan. Diamond drilling of a weak Slingram anomaly over the gossan zone resulted in the discovery of massive sulphide lenses. This was followed in 1956-7 with an intensive drilling program. The result was the delineation of a potential ore body containing an estimated 23 million tons with an overall grade of 0.44% copper, 0.86% lead, 1.95% zinc, 25.73 g/tonne (0.91 oz/ton) silver, 0.28 g/tonne (0.01 oz/ton) gold. Within this package were higher grade zones of copper and lead-zinc mineralization approaching ore grades.A thick blanket of gossan was present and is reported to have caused the drillers considerable trouble as they attempted to penetrate it to get to the underlying sulphides. The gossan, consisting of iron oxides and silica fragments sits on top of the massive sulphides and attains a remarkable thickness of 45.5 meters (150'). Early work had suggested that the gossan was enriched in gold and silver. If this were the case and if the precious metal could be leached out with cyanide, then mining and recovering those values might be economic.With this in mind Northumberland Mines Limited optioned the property from Kennco in 1985. Preliminary leach tests indicated that indeed the gold in particular leached readily. Subsequent drilling of the gossan (using triple core barrel technology for better recovery of the easily ground core) indicated 1,536,363 tonnes (1,690,000 tons) with an average grade of 1.05 g/tonne (0.037 oz/ton) gold and 42.13 g/tonne"

Jan 1, 1993

By B. Tripp

Utah produces a wide variety of industrial rock and mineral commodities, valued in 2005 at a record $758 million (21 percent of the total non-fuel mineral production of Utah). Major commodities produced in 2005 include salts (halite, potash, and magnesium salts), Portland cement, sand and gravel, carbonates (lime, limestone, and dolomite), phosphate, crushed stone, clays, lightweight aggregate (expanded shale and perlite), gypsum, silica, sulfur and sulfuric acid, and building stone. Commodities produced in smaller amounts include diatomite, pumice, gemstones, ornamental stone, fluorspar, and mineral and fossil specimens. Utah is in a period of rapid growth in industrial rock and mineral production; however, some commodities have grown faster than others. The robust western economy has stimulated production of construction-related commodities like sand and gravel, Portland cement raw materials, lime, and building stone, resulting in exploration for raw materials, development of new quarries, and expansion of existing plants

Jan 1, 2007

By Sam Kangwa, Thomson Sinkala

Th e re are three basic types of hole deviations in long hole d ri l l i n g , n a m e l y collar i n g , alignment and tr a j e c t o r y dev i a t i o n s . In mining, the accur a cy in drilling has a significant effect on the effi c a c y and economy of mining oper a t i o n s . This ar t i cl e d e s c ribes the types, s o u r ces and effects of hole deviations in mining oper a t i o n s . The art i cle further demonstrates the economic consequences due to hole dev i a t i o n s .

Jan 1, 2004

By B. Anderson, P. Churak, S. Dewar, A. Johnson, P. Eger

Although vegetation can be successfully established on fine taconite tailings, innovative approaches are needed to reclaim the coarse tailings used for dam construction. Through a series of cooperative projects with various government agencies and industries, EVTAC has been able to develop a unique closure plan. This plan will not only meet current reclamation standards, but also provide mitigation for a disturbed wetland and possibly create a tree plantation in the interior of the basin. By using waste products and exchanging materials, reclamation of the entire basin will be accomplised in a cost effective manner.

Jan 1, 2002

By S. Jennings

The Red Dog zinc-lead-silver deposit is located in the DeLong Mountains of the western Brooks Range in northwest Alaska. The region is located 145 km(90 miles) north of the village of Kotzebue (Fig. 1).Red Dog’s current resource base is 143 Mt (157 million st) averaging 16.1% zinc, 4.3% lead and 83g/t (2.4 oz/st) silver. It is contained in four structurally separate deposits— the Hilltop, Main Deposit, Aqqaluk and the newly discovered Paalaaq deposit. Recent exploration for the Aqqaluk and the Paalaaq deposits has contributed to Cominco American’s understanding of the detailed structural geology of the district and its role in the placement of individual ore bodies.

Jan 1, 1999

By N. A. Eilertsen

Procedures of mining high-calcium limestone underground at the Kimballton mine of the Standard Lime and Cement Co. in Giles County, west-central Virginia, are described. Drilling and blasting procedures arc discussed in detail, and direct mining costs are tabulated in percentage of total cost. Output, about 1,725 tons of limestone a day, is attained with heavy trackless equipment by the room and pillar method of ruining; modified by benching floors. Operating features include underground air compression, electric-eye control of curtained doorways, use of a single jumbo drill rig for all drilling, and an effective plan for maintenance of equipment. The company's safety program has contributed to an outstanding safe mining record. The mina is integrated with a plant on the property which converts the stone to metallurgical and chemical grade lime.

Jan 1, 1964

By Martin Nevens

"In 1998, the Iron Ore Company of Canada initiated an aggressive program to improve the performance of its Carol Lake Concentrator located in Labrador City, Newfoundland. This program was termed the Concentrator Upgrade Program. The Concentrator Upgrade Program was a group of initiatives developed with the common goal of improving the overall process and operations of the IOCC Carol Lake Concentrator. The main goal of the program was to increase the annual production capacity of the concentrator from 18.0 million tomes to 21.6 million tomes. This gain in capacity was to be done mainly through improvements in process iron recovery. The target iron recovery value was 80+% versus a historical value of 70%. This improvement in iron recovery would translate to a natural weight recovery improvement from 44% to 50%.The Concentrator Upgrade Program provided the first opportunity in 30 years to make fimdamental changes to the concentrator flowsheet. To accomplish this, several pilot plants were built to evaluate new circuits. AAer 2 years, a new flowsheet was selected for the primary gravity separation circuit and the magnetite circuit. The centrepiece of the new flowsheet was the introduction of Hindered Settling Separators to the metallurgical process.The Concentrator Upgrade Program has since proceeded into detailed engineering and, as of February 2001, construction. The first one of IOCC’s 3 primary AG Mills (Mill 11) has been converted to the new flowsheet at the time of writing and is in the throes of commissioning. This paper will review the flowsheet development program in the pilot plant for the gravity separation circuit and examine the overall benefits to the operation of the IOCC Carol Lake Concentrator."

Jan 1, 2002

By P. R. Clifford

Phosphogypsum is a byproduct of the manufacture phosphoric acid. There are approximately one billion tons of phosphogypsum stored in stacks in northern and central Florida. The Florida Institute of Phosphate Research (FIPR) is investigating potential uses of phosphogypsum. These include using phosphogypsum as a road base material, as a soil amendment in agriculture, as a daily cover in landfills, and as a construction material. The results of this research will be presented and will be discussed in light of regulatory barriers to the use of phosphogypsum.

Jan 1, 2002

By John J. Murray, Michael T. McRae, Michael A. Krulc, Kathy L. Schuler

The San Vicente Pipeline Tunnel Project involves the construction of an 8.5-foot-diameter water pipeline in an 11 mile tunnel in San Diego, California. The tunnel is located in extremely variable geologic conditions of strong granitic and volcanic rocks, weak sedimentary rocks, abrasive conglomerates, and mixed face conditions. One reach of the tunnel is a 5,200-foot mixed face reach that includes Friars Formation Conglomerate overlying granitic rock. Due to the variable ground conditions in this reach, the use of a TBM was deemed too risky and the contract documents required drill-and-blast and hand mining methods. Although it was not required, the contractor elected to construct this reach using NATM methods. This paper describes the geology of the 5,200-foot mixed-face reach, the design evaluation, and the construction challenges faced on this project.

Jan 1, 2007

By Gloria Fernández

La contaminación por drenaje ácido de mina se considera como la responsabilidad ambiental y económica más grande que actualmente enfrenta la industria minera. En ese sentido, se delimita las áreas afectadas mediante la perforación de pozos de monitoreo a través de un estudio geofísico previo. Por ello, el presente trabajo señala los métodos geofísicos como herramientas que pueden ayudar a delimitar y mapear las zonas afectadas por la contaminación proveniente de drenaje y filtraciones que va desde canchas de relave, pilas de lixiviación a minas abandonadas, etc.

Aug 25, 2002

By Alfred Petrick

This report analyzes the byproducts systems of lead, zinc, uranium, rare earths, iron, aluminum, titanium, and lithium. Specific byproduct metals covered are cadmium, germanium, indium, and thallium from the zinc system; antimony and bismuth from the lead system; vanadium, radium, and scandium from the uranium system; rare-earth oxides from the rare-earth system; and cobalt, gallium hafnium, and rubidium from other systems. The report discusses various metallurgical systems, marginal and incremental production costs of byproduct subsystems, industry structure and organization, and historical data on price, consumption, and supply.

Jan 1, 1973

Vein swarms in metamorphic terranes such as the Otago Schist Belt, New Zealand provide evidence of past hydrothermal flow systems leading to fault initiation and reactivation. A major episode of hydrofracturing and fluid redistribution occurred during early Cretaceous exhumation of the schist belt. As a result, presently exposed lower greenschist facies greyschists in NW Otago are pervaded by abundant quartz-filled hydraulic extension fractures with associated normal faults hosting quartz¦scheelite¦gold mineralisation. Once the effects of Cenozoic folding have been removed, a regional subhorizontal schist foliation contains an aligned array of subvertical hydrofractures striking NNW, striking parallel to a set of low-slip conjugate normal faults; the array extends over an area >1500 km2 and over a depth interval >5 km. The hydrofracture array comprises a mesh of interlinked extensional-shear and pure extension veins. These veins show mutually cross-cutting relations. Extensional hydrofracturing apparently preceded the development of major throughgoing normal faults. Low-displacement normal faults are infilled with laminated quartz (¦ scheelite) veins (

Jan 1, 2002

By Pratheesh George

Solid state galvanic cell with CaF2 as the electrolyte was employed for determining the thermodynamic properties of Nb-Al binary alloys in the temperature range of 973-1073 K. The activities and activity coefficients of Al in NbAl3 were determined. The experimental procedure and the design and construction of the experimental setup have been also explained in detail. Aluminum activity in NbAl3 increased with increase in temperature and shows a strong negative deviation from ideality. The activities of aluminum in NbAl3 were determined to be 0.0165 and 0.0289 at 973 and 1073 K respectively. The stability of NbAl3 has been compared with other available intermetallic systems.

Jan 1, 2006

By Carlos Soria

El presente texto describe los Sistemas de Gerencia de la Información y su aplicación en la industria minera con el objetivo de optimizar la gestión total de la empresa. Dichos sistemas manejan información del proceso y sus valores de producción, cálculos, consumos de energia, emisiones de plantas, tiempos de funcionamiento de equipos, eventos, alarmas, mediciones de laboratorio y control estadístico, etc. De forma que dicha información pueda ser reunida y consolidada, convirtiéndose en materia de significado y relevancia disponible en base a análisis, reportes, listas, tendencias y gráficos para que el usuario final de una planta o en sus oficina pueda tomar mejores decisiones.

Jul 17, 2000

By J. A. Bakken, T. Magnusson, G. Sævarsdottir

This paper describes measurements of current and voltage done on submerged arc furnaces. The aim is to focus on and attempt to separate from one another the electric arc current and the current bypassing the arc through the charge. Toward this goal two measurement campaigns on AC-arcs burning on coke beds are ac-counted for. The first was done on a 150 kVA pilot furnace at SINTEF in Trondheim Norway, and the second one was done on a 48 MVA industrial furnace run by Icelandic Alloys in Iceland. The measurements were compared to simulations employing an advanced MFD arc model. The main results are that a coke bed does not necessarily behave as a linear conductor. However the warmer chemically transformed part of an operating Si-metal or FeSi furnace probably exhibits linear behaviour and passes a considerable fraction of the phase current, perhaps on some operating conditions, as much as 50%.

Jan 1, 2007