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By E. V. Cilento, K. A. DiGregorio, R. C. Lantz

"K. A. DIGREGORIO, E. v. CILENTO, AND R. c. LANTZ. Measurement of superoxide release from single pulmonary alueolar macrophages. Am. J . Physiol. 252 (Cell Physiol. 21 ): C677-C683, 1987.-An electrooptical method was developed to quantify superoxide (02) release from single rat pulmonary alveolar macrophages (PAM) during adherence to the bottom of a culture dish. This was done by measuring the reduction of nitro blue tetrazolium (NBT) to a diformazan precipitate at 550 nm from videorecorded images of individual cells. Temporal changes in cell optical density, which are proportional to the mass of diformazan produced, were calculated from videophotometric measurements of the change in light intensity over individual cells. Total diformazan produced increased 78 and 1263 with an increase in NBT from 0.5 to 1.0 and 2.0 mg/ml, respectively. Total diformazan produced and maximum rate of production among individual PAM varied two- to threefold providing strong evidence for heterogeneity in 02 production. Specific inhibition of 02 production by superoxide dismutase, iodoacetate, and chlorpromazine significantly reduced the total diformazan produced and maximum rate of diformazan production. Hydrogen peroxide was not involved in NBT reduction, since catalase alone did not significantly change diformazan production. This novel method to quantify 02 release from single PAM should be valuable in analyzing heterogeneity and single cell kinetics of O; production, in assessing the effects of exposure of cells to particulates on O; release, and in relating release to electrophysiological measurements.rat; nitro blue tetrazolium; macrophage heterogeneity; single cell kinetic PULMONARY ALVEOLAR MACROPHAGES (PAM) protect the lungs by phagocytizing foreign debris and bacteria (24). This process involves ingestion as well as destruction of foreign matter. Phagocytosis is usually accompanied by a respiratory burst that increases cellular oxygen consumption and glucose metabolism in the hexose monophosphate shunt (7), which leads to the release of highly reactive oxygen metabolites at the surface of the · plasma membrane (6, 27). These agents have been implicated in the killing of bacteria by phagocytes (22), but have also been shown to be toxic and have been linked to cancer, emphysema, arthritis, diabetes, and other diseases (17, 22, 30). Toxic effects may be a result of either an abnormally low production of metabolites, resulting in damage to lung tissue by respirable bacteria and dusts, or an abnormally high production, resulting in direct damage to lung tissue by metabolites themselves."

Jan 1, 1989

In 2005, data obtained from the Mine Safety and Health Administration (MSHA) indicated a total of 922 underground (6.3%) and 13,744 surface (93.7%) mining operations.1

Jan 1, 2008

By H. M. Cooper, R. F. Abernethy

Determination of the fusibility of coal ash consists in melting a pyramid of the ash to fluid under prescribed conditions . The conditions of the test are specified by the American Society for Testing Materials4/ and must be adhered to strictly if comparable results are to be obtained . The Society formerly specified a particular type of furnace , but with improvements in design of both electric and gas furnaces , it was decided by the Society to specify only essential details of the test . The Chairman of Committee D - 5 , Coal and Coke , of the American Society for Testing Materials suggested that the Coal Analysis Section of the Bureau of Mines conduct a cooperative investigation on the effect of furnace type and atmosphere upon fusibility of coal ash . The Coal Analysis Section enlisted the aid of a number of laboratories using the more common furnaces to cooperate in the investigation . Four types of gas furnaces burning natural and manufactured gases and two types of electric furnaces with different methods of maintaining a reducing atmosphere were employed . The results from the survey are tabulated herein , and some comparisons are made . There were not enough data from any particular furnace and atmosphere to make a reliable statistical analysis . However , definite tendencies are evident , and attention is called to them by direct comparison. in tables .

Oct 1, 1943

By B. J. Moore

This publication contains analyses and related source data for 234 natural gas samples from wells and pipelines in 21 States and 1 foreign country. All of the samples were obtained and analyzed during calendar year 1975 as a part of Bureau of Mines investigations of the occurrences of helium in natural gases of countries with free market economies. This survey has been conducted in the United States by the Bureau of Mines since 1917. In late 1965, the survey was expanded to include foreign gasfields. The analyses published herein were made by mass spectrometer and n special helium analysis apparatus, which are described in Bureau of Mines Bulletins 4862 and 576.3 The results of the investigation of the occurrences of helium are published annually to make the information available as soon as possible to the gas industry and the public in general. Seventeen previous publications have presented the results of 10,831 gas analyses prior to 1975. The first 3, Bulletins 486,4 576,5 and 617,6 contain analyses and related source data on 5,218 gas samples collected from 1917 through 1960. The other 14

Jan 1, 1976

By W. E. Anable

The Bureau of Mines studied the purification of commercially available yttrium by melting it in a 100-kw electron-beam furnace. Button-scale melts were made to determine the ultimate purification that could be attained by melting yttrium at 1,733° to 1,770° C at low pressure (0.05 to 0.1 micron) for 1 to 120 minutes. In addition, numerous melts were made to study the effect of doping yttrium with carbon, 17 selected metallic additions, and 3 compounds. Except for nickel and zirconium, the metallic impurities in yttrium were lowered significantly on extended treatment; silicon was lowered only slightly. The nonmetallic impurities} oxygen, nitrogen, and carbon, were not lowered except on short exposures. In isolated instances, the oxygen content was lowered from 5,860 ppm to about 5,000 ppm. In most instances the carbon con-tent was lowered from 545 to about 220 ppm in 20 minutes and then increased again. It was concluded that yttrium cannot be purified by direct heating or by the doping technique employed.

Jan 1, 1965

By W. F. Marshall

This report describes exhaust-emission data from 10 diesel engines: six 4-cycle, direct-injection, naturally aspirated engines; two 4-cycle, direct-injection, turbocharged engines; one 4-cycle, precombustion-chamber, turbo-charged engine; and one 2-cycle, direct-injection engine. These engines were tested over a 3-year period (1968-70). Lowest emissions were obtained with a precombustion-chamber engine. Emissions from the 2-cycle, direct-injection engine fell within the range of emission rates for the 4-cycle, naturally aspirated, direct-injection engines. Excluding the precombustion-chamber engine and excepting one of the 4-cycle, naturally aspirated engines, carbon monoxide emission rates were about the same for all engines tested. Test data on smoke, odor, and emissions of hydrocarbons, oxides of nitro-gen, carbon monoxide, and aldehydes are given.

Jan 1, 1971

By Thomas R. Bur

The patterns of variation of the 21 anisotropic elastic constants with direction arc presented for all of the symmetry systems that are normally expected to occur in rocks and in the constituent minerals. The exception, which is not discussed, is the triclinic system for which no elastic constants are available. Variations are shown for rotations about the principal axes by means of polar graphs. These include graphs for all of the n-fold symmetry axes possible for elastic symmetry and thus make it possible to visualize variational patterns for rotations about any n-fold axis. Variations throughout space are shown by means of equal area projections for the only constants (those relating axial stress to axial strain) that are uniquely defined by a single closed surface. For those unfamiliar with the compliance (Sij) and stiffness (cij) coefficients, the variations that can be shown by Young's modulus (E), Poisson's ratio (v), and shear modulus (G) are also given.

Jan 1, 2012

By H. Dolezal

An investigation was made on the use of magnesium for the direct reduction of rutile to make low-cost, offgrade titanium which could be upgraded to an acceptable grade of metal by electrorefining. Reductions made with charges containing magnesium chloride under hydrogen yielded products with oxygen con-tests close to the theoretical equilibrium composition. Two reduction products were made from rutile for use in electrorefining amenability tests: (1) a product from reduction in an inert atmosphere which contained 88.9 percent titanium and 4.42 percent oxygen, and (2) a product from reduction in a hydro-gen atmosphere which contained 92.5 percent titanium and 2.40 percent oxygen. Reduction products obtained under both of these conditions were amenable to electrorefining.

Jan 1, 1965

By H. L. Bibbs, H. D. Snedden

"INTRODUCTION The use of beryllium and its alloys has increased rapidly during the last decade. Further expansion of its use is limited; in part, by lack of adequately developed ore reserves. The principal commercial beryllium mineral is beryl, which is found chiefly in pegmatites and produced for market as a byproduct of the mica and feldspar industries. The coarse beryl is mined selectively, sobbed and sorted by hand, and then sold without further beneficiation. The known reserves of coarse beryl are small. No method has been available for concentrating small disseminated beryl crystals, so ores of this type have not been mined or have been left on waste dumps. Disseminated ore in low-grade unmined areas and waste dumps on developed properties is a potential source of beryl, provided a method is developed for its beneficiation.Published literature on the concentration of beryl is lacking in detail or deals chiefly with tests on artificial mixtures of pure minerals, and procedures as given were not applicable to the beryl ores tested at the Salt Lake Station. The testing procedures described in this report are independent developments. By employing these procedures, beryl was satisfactorily con¬centrated from several run-of-mine and dump ores, although these ores wore low in grade and part of the contained beryl was finely crystalline and disseminated.Beryl, quartz, and feldspar, when ground to flotation sizes, are so alike in color and general appearance that they cannot he distinguished by visual observation. The progress of the work depended on rapid determination of the grade of test products by means of the petrographic microscope. Small samples of concentrates and tailings were often cut after each addition of reagents, dried, and examined under the microscope."

May 1, 1947

By W. R. McDonald

Part of the U.S. Bureau of Mines mission is to supply the U.S. mineral industries with information that is useful in planning to meet the Nation's critical and strategic mineral needs if a national emergency occurs. The Bureau conducted laboratory research including operating a nominal 100 lblh pilot plant to demonstrate the recovery and concentration of chromite by gravity and flotation operations from three northern California mineral deposits. Gravity beneficiation test results show that concentrates contained as much as 52 pet chromic oxide (CrZ03) with recoveries of about 80 pet. Results from the bench-scale unit operations of mineral liberation, tabling, vanning, spiraling, pinch sluice, work index, and thickener area determination tests are presented in this report.

Jan 1, 1990

By R. J. Leary

Significant improvements in surface conditions or mechanical properties of steels have been attributed by several investigators to ladle additions of small quantities of rare-earth metals or their oxides. To investigate systematically these effects in wrought and in cast plain carbon and alloy mechanical steels containing approximately 0.35 percent carbon, heats of four representative compositions were melted by the Bureau of Mines in a 4-ton open-hearth furnace. Each heat was cast into three sets of ingots to exemplify respectively, treatments with (1) rare-earth metals, (2) rare-earth metal oxides, and (3) an untreated set as a control. The development of melting, casting and rolling practices is described and discussed. Lance injection of oxygen shortly after melt raised the temperature of the metal immediately as much as 500° F., principally because mechanical agitation exposed the high-carbon metal to the flame and furnace root. An exceptional degree of superheat in the metal at the termination of the refining period was attributed to oxygen injection during the refining period. Bath temperatures higher than industrial practice were permitted by the all-basic furnace lining. Rates of carbon elimination as high as 0.036 percent carbon per minute were achieved by oxygen injections.

Jan 1, 1961

By Clayton M. Rumsey

In 1984, the U.S. Bureau of Mines conducted a mineral survey of a 26,598-acre study area which includes the 23,702-acre Mt. Limbo Wilderness Study Area (NV-020-201). The study area is 65 miles northeast of Reno, NV, and is underlain mainly by Cretaceous granodiorite that comprises the Selenite Range. Tertiary basalt, rhyolite, and sedimentary rock as well as Quaternary alluvium and lake deposits are exposed near the study area boundary. Mines just north of the area in the Hooker mining district produced tungsten ore in the 1940's and 1950?s. Similar deposits are not known in the study area. Disseminated gold is in sinter about 6 miles west of the study area and at several other locations regionally.

Jan 1, 1986

By H. F. Weaver

The 19th National First-Aid and Mine Rescue Contest was held in the Civic Center, Charleston, w. Va., on October 2, 3, and 4, 1961. The meet was sponsored by the Bureau of Mines and the Joseph A. Holmes Safety Association, in cooperation with State mine inspection agencies, management and labor of the mineral extractive industries, and other groups interested in safety. The Arrangements Committee, as authorized by the General Committee, made the necessary arrangements for conducting the 1961 contest. Members of the Arrangements Committee were: George Trevorrow (chairman), Bituminous Coal Operators' Association; James B. Benson, Southern Coal Producers' Association; Charles Ferguson, United Mine Workers of America; Harry Gandy, Jr., National Coal Association; and James Westfield, Bureau of Mines.

Jan 1, 1962

By A. W. Deurbrouck

The separations achieved by eight conventional cyclone washers have been evaluated to determine their performance when processing intermediate size coal of 28 mesh bottom size. The dense-medium cyclones provided efficient, sharp separations in treating feeds of up to 44 percent of near-gravity material at separating specific gravities ranging from 1.42 to 1,55 (one separation of a secondary feed was made at 1.63). Complete washability analyses are shown by sizes of the composite feed to these cyclones. The magnetite losses per ton of coal processed ranged from 0.6 to 2.0 pounds; however, of the eight plants reporting losses, seven indicated magnetite losses were 1.1 pounds or less per ton of coal processed.

Jan 1, 1972

By W. F. Faragher, W. A. HORNE

Previous interrogation of German scientific personnel by numerous in- vestigators and the examination of evacuated documents indicated that fur- ther information was desirable on a miscellany of products and processes of interest to the Petroleum Industry. Accordingly, Dr. Pier and a large number of other men of the I.G. Farbenindustrie, A.G. plant at Ludwigshafen/ Oppau were further interrogated in July-1945. The information contained in this report supplements that previously reported in the CIOS report of 16 August, 1945: "Report on Investigations by Fuels and Lubricants Teams at the I. G. Farbenindustrie A.G. works at Ludwigshafen and Oppau", edited by Lt. Col. R. Holroyd, (FP).

Aug 1, 1943

By E. J. Gleim

This report describes a trip to Europe in the interest of safety in coal mines. It reviews the Eighth International Conference of Directors of Safety in Mines Re-search, which met in Dortmund-Derne, Germany, July 5-10, 1954, to discuss results of studies made in different countries to improve health and safety conditions under-ground. It also summarizes information on subjects of special interest in the United States gained by the writer in visits to mining experiment stations in Belgium, France, and England. The efforts being made to protect life and property underground were discussed, and ideas and experiences were interchanged freely, not only during the conference but also during visits to the several countries. Helpful information was obtained on many topics of interest, but time did not permit as thorough a discussion on some of them as might be desired.

Jan 1, 1956

By S. H. Ash

NO MORE important question has come before the coal-mining industry in many places, especially in the anthracite region of Pennsylvania, than prevention of stream pollution by mine drainage. Available information on acid mine drainage in the anthracite region of Pennsylvania indicates that a pollution problem must be solved in any program of anthracite mine drainage. The major problem concerns satisfactory disposal of the daily average mine-water discharge of 327,000 gallons per minute (g. p. m.), or 472 million gallons per day (g. p. d.), containing a free-acid load of 431 tons or a total acid load of 934 tons a clay as H2S04. This report indicates the scope of the problem and gives some suggestions concerning its solution.

Jan 1, 1951

By J. K. Whyatt

The U.S. Bureau of Mines conducted an overcore stress measurement on the 5300 level of the Lucky Friday Mine, Mullan, ID, to investigate the stress regime around an experimental stope in a rock-burst-prone mine. The result indicated a stress field with unexpected magnitude and orientation [s 1 ?135 MPa (19,600 psi) oriented S 80° W). An unusual amount of rock-burst activity was encountered during subsequent excavation. A careful review of the overcore data suggested the overcore strain measurements were valid. Moreover, concentrated rock-burst activity suggested that the measured stress field did exist, but was localized and therefore did not represent the far-field in situ stress field.

Jan 1, 2010

By Fred N. Kissell

Air recirculation caused by dust scrubbers at coal mine working faces was examined by the Federal Bureau of Mines with regard to the potential hazards caused by a possible buildup of methane gas. A theoretical analysis indicated that there was no apriori way to predict the effect of scrubber recirculation on methane concentration levels. Experiments conducted in a full-scale model of a working face area indicated that methane levels were dependent to a great extent on the location of the scrubber exhaust, but that the scrubber recirculation did not substantially increase the methane concentration above those levels that would have prevailed were the scrubber not in operation. An analysis of two underground scrubber trials showed that the scrubbers had no significant effect on methane levels, and a review of explosions attributed to recirculation showed that these were characterized by a lack of fresh air as well as recirculation. It was concluded that high methane levels are due more to a lack of fresh air than to recirculation.

Jan 1, 1975

By D. Harrington

The desirability of efficient control of air currents, and the necessity of supplying metal-mine workers with better and safer working conditions, has created an active interest in metal-mine ventilation, especially in recent years. This paper discusses the subject both with regard to efficiency and economy, as well as safety and health. It is based on personal observations of the writer from over four year's study of metal mines in six States, in which more than 50 mines were visited. Many of these were studied in detail; in all several thousand working places were examined, and readings taken relative to ventilation run into the tens of thousands.Object of ventilating metal mines:Whereas in coal mines ventilation is generally regarded as essential, in many metal mines, especially shallow ones, the operators pay little attention to ventilation, or ignore it altogether. Recent shortage of labor, and numerous accidents to which State compensation laws have directed attention, are causing metal-mine operators to regard ventilation more seriously, especially in deep, large mines.There is, in fact, greater necessity for adequate ventilation of metal mines than of coal mines. The latter require air currents to remove explosive gases and the fumes of explosives, but metal mines, in addition to the need of removing fumes of explosives, and occasionally explosive gases, frequently have need of removing dusts dangerous to health, reduction of high temperatures and high humidity, and removal of inert but unhealthful gases like CO2 and nitrugen. The generally accepted superior healthfulness of coal miners as compared with metal miners, is probably due in large part to the better air circulation in working places of coal mines.

Jun 1, 1920