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By N. S. Dalal, A. H. Hoffman, X. Shi, D. E. Banks, J. K. H. Ma, Y. Rojanasakul

Excessive production of reactive oxygen radicals by alveolar macrophages is proposed to play an important role in oxidative lung injury. A major product of oxygen radical formation is the highly reactive hydroxyl radical (•OH) generated via a biologic Fenton reaction. In addition to its known ability to induce lipid peroxidation, recent studies have suggested that the •OH may exert its cytotoxic effect through the alteration of [Ca2+], homeostasis. To test this potential mechanism as well as to investigate the relationship between •OH and Ca" overloading in cytotoxic injury, isolated rat alveolar macrophages were exposed to externally generated radical system, H2O2 (0.01 to 1 mM) and Fe (1 mM) and their [Ca2+] levels and cell injury were monitored using quantitative fluorescence microscopy with the aid of the specific Ca" indicator, Fura-2, and membrane integrity indicator, propidium iodide. Electron spin resonance measurements using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) confirmed the production of the .OH radical by this system. Upon the addition of the radicals, the macrophages displayed a rapid initial rise in [Ca2+] which was followed by a slower but more pronounced [Ca2+], elevation that reached a level 3 to 5 times higher than the basal level. This process preceded cell death as evident by nuclear propidium iodide fluorescence. Depletion of extracellular Ca" inhibited both the [Ca2+], response and cell injury. Preincubation of the cells with the Ca" channel blocker verapamil or .0H radical scavenger mannitol similarly inhibited the [Ca2+], rise and loss of viability. Firefly luciferase assay of cellular ATP content demonstrated that the alterations in [Ca2+], following .0H treatment preceded the depletion of ATP. Changes in membrane potential caused by Na* substitution with K* had no significant effect on either the unstimulated or stimulated [Ca"], levels. Taken together, these measurements indicate that .OH-induced injury in alveolar macrophages is associated with the alteration in [Ca2+], homeostasis. The mechanism of •OH-induced [Ca2+] loading is not due to nonspecific membrane damage or energy depletion, but mainly due to an increase in Ca2+ influx through Ca2+ selective channels. This Ca2+ over-load state as well as energy depletion caused by the oxidant may activate certain cellular degradative processes leading to cell injury and death.

Nov 1, 1995

By T. E. Ackman

The Bureau of Mines conducted a study of current trends in methods employed by the coal industry to dispose of acid mine drainage (AMD) treatment sludge. Thirty-three AMD treatment plants, operated by 11 Pennsylvania coal companies, were randomly surveyed. These plants provided data for calculating sludge volumes, as well as information on sludge settling, transportation, and disposal. Onsite visits allowed observation of problems associated with the various methods of sludge disposal: (1) disposal into a deep mine, (2) permanent retention in ponds, (3) disposal at an active coal refuse area, and (4) onsite burial. Method 1 is the most frequently used and the most environmentally sound. It is apparent, based on this representative sampling of AMD treatment plants, that the magnitude of sludge production is such that an aggressive and directed effort in reduction of sludge volume is seriously needed. The areas of major concern are (1) the amount of surface land required for sludge storage and disposal, (2) reclamation of these disturbed surface areas, and (3) effective and efficient means of removing, transporting, and disposing of AMD sludge. In this report, an engineering approach to the practical problems associated with the existing disposal methods is presented, together with recommendations for future research.

Jan 1, 1982

By M. H. Kline, Wing G. Agnew

"INTRODUCTION The Yancey-Crawford tract, located 1-1/2 nines east of Yancey station on the Norfolk & Western Railway in Rockingham County, Va. was from 1917 to 1941 considered an unusually promising manganese prospect. Because of the favorable geologic formations and because of the common occurrence of manganese in the district and Virginia's large production of these minerals from this area, geological report 3/ have listed this tract as the No. 1 prospect in the State. During World War I, extensive geologic studies were made to locate manganese deposits similar to those exploited at the Crimera mine near Waynesboro to alleviate this mineral shortage during the existing emergency.In September 1941 the Bureau of Mines started exploratory drilling on the tract in an effort to discover and block out reserves of manganese minerals as authorized by the 76th Congress under the Strategic Materials Act. After five drill holes wore sunk, the project was terminated October 1941."

Apr 1, 1948

By T. E. Green, E. F. Spano, W. J. Campbell

A combined ion exchange X- ray spectrographic method was evaluated for the determination of 11 metallic elements in high - purity tungsten : Aluminum , calcium , chromium , cobalt , copper , iron , magnesium , manganese , nickel , titanium , and zinc . Copper , nickel , and manganese in the 5- to 100 - microgram range ( 1 to 20 parts per million based on 5 - gram samples of tungsten ) , calcium in the 10- to 100 - microgram range , and cobalt in the 5- to 20 - microgram range can be determined within an accuracy of ± 10 percent of the amount present . Limits of detection of these elements are 0.05 to 0.14 microgram . The overall method was unsatisfactory for the determination of aluminum , chromium , iron , magnesium , titanium and zinc in tungsten .

Jan 1, 1964

By O. M. Bishop

"SUMMARYAs a result of the increased demand for fluorspar during the war, the Bureau of Mines investigated numerous fluorspar properties in the southern Illinois field, which is centered in Rosiclare. Among these the J. J. Shelby 40-acre tract on the western edge of the district presented favorable factors that caused it to be chosen /or exploration.H. G. Spiller, formen lessee of the property, had explored the Shelby vein by means of an adit level and winze, and showed it to contain goad values in zinc and fluorspar at the depth explored. A diamond-drill hole with which Spiller explored the vein 78 feet southwest of the winze, however, failed to cut ore. After studying the field evidence, the Bureau concluded that the vein merited further exploration, particularly at a depth of about 440 feet, where the Fredonia limestone would form the foot-wall of the vein and the hanging wall would be the competent Cypress sandstone.Between October 17, 1944, and March 26, 1945, three diamond-drill holes were bored for a total inclined depth of 1,592 feet. Holes 1 and spaced approximately 500 feet apart, explored the vein at 440 feet 4 below the surface. The economic mineralization existed in the vein where cut. Hole 3 cut the fault at approximately 300 feet below the outcrop but failed to find any vein matter except stringers of calcite with small amounts of pyrite."

Apr 1, 1947

By M. Hayashi

The Bureau of Mines conducted laboratory studies on Idaho mudstones to examine techniques for extracting vanadium. Recovery of vanadium from low-grade sources could contribute to future vanadium production and reduce reliance on imports. An Idaho mudstone surface sample containing 0.30 pct V205 and an underground sample containing 0.21 pct V205 were used in the extraction tests. Leaching of the surface sample for 18 h at 800 C with the addition of up to 1,000 lb/ton H2S04 recovered 70 pct of the vanadium. How-ever, leaching of the underground sample under the same conditions re-covered only 47 pct. By adding 15 wt pct NaCl and roasting the samples at 7500 C for 2 h, followed by leaching with 800 lb/ton H2S04, vanadium extractions were increased to 78 pct from the surface sample and 83 pct from the underground sample. Water leaching of samples roasted at 7500 C for 4 h with a 25-wt-pct NaCI addition yielded about 60 pct of the vanadium from both surface and underground samples. Autoclave leaching at 2000 C for 3 h with 1,000 Ib/ton H2S04 extracted 97 pct of the vanadium from the surface sample and 86 pct from the underground sample. An exploratory solvent extraction investigation to purify and concentrate vanadium in the leach solution using several organic reagents was also conducted.

Jan 1, 1985

By J. P. Coughlin

The U.S. Bureau of Mines has developed a monitoring system that acquires and analyzes data for use in determining the conditions that may precede mountain bumps in coal mines. Based on a UNIX workstation linked to an array of geophones in a working longwall operation, the system captures complete waveforms of microseismic events and simultaneously obtains continuous samples of the voltage levels of each geophone. Event rates and locations are calculated and displayed in real time on the UNIX workstation, which is situated in an underground instrumentation room. These results also are transmitted from the workstation to a display computer near the longwall face. The system runs continuously and has the capability to acquire, analyze, display, and archive microseismic (transient) data and single point data, such as closure and pressure changes, simultaneously.

Jan 1, 1993

By A. C. Richardson

The mine of the Porter Coal Co. is located at the town of Porter in the northwestern part of Jefferson County, Ala., about 20 miles west of Birmingham. The operations in this mine are confined to the middle and bottom benches of the Mary Lee bed. The coal from the Porter mine is handpicked and washed before being placed on the market. The handpicked lump coal and the washed egg and nut coal are sold chiefly as domestic and steam-raising fuel. The coal finer than 1 inch is washed in 2-compartment jigs and utilized in the manufacture of metallurgical coke. The coal company has found that, when coal ranging in size from 1 to 0 inch is washed in jigs, a considerable amount of high-ash material finer than 3/16 inch remains in the washed coal. This paper gives the results of an investigation which was conducted for the purpose of determining the washing characteristics of the through 3/16-inch raw coal and the extent to which the ash might be reduced by means of coal-washing tables. This investigation has been made in connection with an extensive study of the coal-washing problems now being conducted by the United States Bureau of Mines and the University of Alabama, with the cooperation of the coal-mining companies of the State.

Jan 1, 1933

By V. Vallyathan, Xianglin Shi, N. S. Dalai

While Cr(VI) is a known carcinogen, the underlying biochemical mechanism is still not fully understood (1). In a pioneering study Jennette (2) utilized electron spin resonance (ESR) spectroscopy to demonstrate that a long-lived Cr(V) species is generated during the reduction of Cr(VI) by microsomes in the presence of NADPH. Later Wetterhahn and co-workers (3, 4) showed that incubation of chromate with isolated rat liver mitochondria causes the reduction of Cr(VI), as well as the formation of a Cr(V) species. Analogous Cr(V) species have also been detected in the reduction of Cr(VI) by other cellular systems such as Hanserulla polymorphared (5) and blood cells (6, 7). All these as well as other studies (8-12) have suggested that this Cr(V) species plays a significant role in the mechanism of Cr(VI) toxicity. Thus far, however, the chemical structure of this dominant Cr(V) species formed in cellular systems has not been identified, and this observation provided an impetus for the present investigation. Another reason for undertaking this study was that some recent reports (10-16) suggest that hydroxyl ('OH) radicals may also play an important role in the mechanism of Cr(VI) toxicity. In particular, it has been shown that OH radicals are formed in reactions between Cr(V) species and H2O2 (13-16), and that the radical yield depends on the chemical structure of the Cr(V) species (15). For example, while Cr(V)-diol complexes efficiently generate OH radicals, another Cr(V) species, the tetraperoxochromate (CrO3/8) ion, does not (15). Thus in the present study, we focused our attention on the following: (a) structural identification of the Cr(V) species generated in the reduction of Cr(VI) by subcellular as well as cellular systems, using microsomes, mitochondria, and Escherichia coli; (b) possible detection of OH radical in the same systems since there is no earlier report of chromium-mediated generation of 'OH radicals in a cellular system; (c) possible involvement of molecular oxygen in chromium-related OH radical generation since a recent report (17) indicated that Cr(VI) mutagenesis is strongly oxygen dependent; and (d) elucidation of the mechanism of OH radical formation in these systems.

Mar 1, 1992

By D. S. Kingery

Experiments initiated by the Bureau of Mines on August 26. 1969, and recent work of others, have demonstrated the effectiveness of ventilation for controlling concentrations of respirable coal mine dust. Substantial reductions in dust concentrations have been attained by increasing the volume and rate of air movement across the face and by controlling the airflow pattern. Ventilation experiments conducted by the Bureau using high-pressure fans as auxiliary ventilation units showed that lace-generated dust could he effectively controlled in five mines employing continuous mining machines. Additional data was obtained on industry installations in two mines using similar ventilation systems. By maintaining an airflow approaching 100 fpm across the entry, the experimental system reduced the concentration of respirable dust by factors as great as 6.4. In all mines where the system was used the face-generated dust concentrations were reduced to below 3 mg/m3. Total respirable dust in two cases was above the 3 mg/m value because of the dust content of the intake air. In some mines. depending upon the type of coal being mined and other dust control factors in use, it was possible to Obtain concentrations of less than 2 mg/m Although the technology for the application of the dust control system investigated is readily available, it is evident that additional engineering studies should he made in each mine where the system is to be applied.

Jan 1, 1969

By Shiro Watanabe

To determine the potentialities of nickel as a substitute for cobalt in catalysts for the synthesis of hydrocarbons from carbon monoxide and hydrogen, RESULTS The maximum oil yields obtained in bench-scale equipment were as follows: Using 100N1:20Mn:100 kaolin:200 diatomaceous earth catalyst, a maximum yield of 133.8 cm.3/m.3 of pure CO+2H2 was obtained from one pass of the feed gas, With a nickel:cobalt mixed catalyst (Ni:Co - 3:7) having the composition 100(Ni+Co):8MgO: 5Th02:200 diatomaceous earth, a maximum of 172.2 cm.3/m.3 of pure C0+2H2 was obtained.

Jan 1, 1951

By W. D. Mcmillan

Preliminary examination of the north-central Kansas clay deposits was made by the junior author during March 1943. He was accompanied by Norman Plummer, ceramist of the State Geological Survey of Kansas. Three areas Nacre selected for further investigation. Detailed field investigation by the Bureau, consisting of hand auger drilling, trenching, anti. test pitting to obtain representative samples of the clays was carried on from April to June 1943. Field .work was under the direction of Edgar B. Butte and Richard L. Schumacher, former Bureau of Mines engineers. The samples taken were analyzed at the Bureau of Mines laboratory at Rolla, Mo. Factual data obtained from the field investigation and laboratory work are set forth in this report.

Jan 1, 1948

By Stephen D. Hill

The Bureau of Mines devised and constructed a modified Knudsen effusion apparatus, permitting a constant measure of the weight of effusing vapor, to determine the equilibrium vapor pressure of metal halides at temperatures up to 1,200° K and over the pressure range 10-5 to 10-2 torr. The reliability of the apparatus was established by determining the vapor pressure of potassium chloride. After correcting for partial dimerization of the vapor, data obtained on solid KCl between 750° and 950° K can be expressed by the following equation:

Jan 1, 1966

By Ernest W. Loya

The Bureau of Mines has developed a computer program for calculating the composition of gravimetric primary standard gas mixtures. The Fortran IV program applies corrections due to buoyancy variations of the cylinder and inaccuracies of the balance weights. The program also determines the statistical error due to the sensitivity and precision of the balance and applies the analytical error of the weighed gases.

Jan 1, 1985

By Eric R. Bauer

This Bureau of Mines manual is intended to provide a better understanding of ground movement and the technology available for measuring it, The manual deals with convergence, strata separation, lateral roof movement, stress, and support load in underground mines. The instruments that measure these ground control parameters are described in detail. Step-by-step procedures for selecting the appropriate instrument are presented, which consider such factors as approximate cost, installation procedures, data collection, and data interpretation; and an instrument selection worksheet is provided to facilitate the instrument selection process. Actual instrument case studies and a list of instrument suppliers are presented in the appendixes.

Jan 1, 1985

By Arne Landsberg

A study of the chlorination kinetics of germanium, silicon, iron, tungsten, molybdenum, columbium, and tantalum has been made to determine the effects of temperature, chlorine concentration, geometric surface area and gamma radiation. The reaction products were volatile at the temperatures used this making it possible to follow the reaction rates by weight loss of the solid. Chlorination rates of germanium, silicon, and iron were found to be directly proportional to chlorine concentration while the rates for tungsten, molybdenum, columbium, and tantalum were proportional to the 0.5 to 0.6 power of chlorine concentration. A good correlation of reaction rate and geometric surface areas was not obtained because the true surface area of the samples could not be measured. Intense gamma radiation had no effect on reaction rates. The Arrhenius activation energies determined over the temperatures used are as follows: Germanium, 27 kcal/mole (233°-241° C); silicon 33 kcaL/mole (375°-517° C); iron, cold rolled, 20 kcal/mGle (259°-325° C) annealed, 21 kcal/mole (293°-337° C); tungsten, 43 kcal/mole (617-776° C); molybdenum, 37 kcal/mole (445°-4910 C); columbium) 34 kcal/mole (229°?255° C); and tantalum, 29 kcal/mole (370°-449° C).

Jan 1, 1965

By Phillip R. Moyle

In 1985 the U.S. Bureau of Mines evaluated the mineral resources of tie Bruneau River and Jarbidge River study areas, Owyhee County, ID, for the U.S. Bureau of Land Management. The study areas, separated by a narrow corridor, include 90,000 acres of the 107,020-acre Bruneau River Wilderness Study Area (ID-111-17) and 47,000 acres of the 75,340-acre Jarbidge River Wilderness Study Area (ID-17-11). They lie 26 miles and 55 miles, respectively, due south of Mountain Home, ID. Approximately 38 placer claims for gold and 182 lode and placer claims for jasper, agate, and limestone were located within and adjacent to the study areas from 1893 to 1981. Currently, there are eight mining claims for jasper at Indian Hot Springs along the corridor between the study areas.

Jan 1, 1987

By Edward B. Kendall

[This paper is one of a series being prepared far and published by the United States Bureau of Minus describing the methods of mining used and operating costs obtained in producing land and gravel from deposits throughout the United States. This circular describes operations at the Eliot plant of the Pacific Coast Aggregates (Inc.). in Livermore Valley near San Francisco, Calif. These papers are designed to disseminate technical information regarding the methods used. The cost tabulations represent local expenditures only and not total production posts. It is recognized that publication of total costs might in some instances cause embarrassment to individual producers as well as to the industry as a whole. On the other hand, operating costs are essential to the technical discussion and study of methods employed. The attention of the reader is specifically called to this differentiation in order that no misunderstanding of the scope of the cost tabulations shall ensue.]

Jan 1, 1933

By D. W. Frommer, L. Bonicatto, M. M. Fine

A mineral - dressing investigation was conducted to demonstrate the ability of an anionic silica - flotation process to produce high- grade concentrates from submarginal iron ores of the western Mesabi and Menominee ranges . Commercially available equipment and reagents were used . Samples from the Menominee range were exclusively from the Groveland , Mich . , mine and contained hematite as the chief iron - bearing mineral . Bench- scale investigations established that the anionic silica flotation method can function effectively on a variety of undeslimed ores . Continuous tests completed on one Mesabi semitaconite ore and on Groveland mill feed , have verified the validity of the bench research . The Mesabi samples yielded a concentrate containing 60.3 percent Fe and 6.0 percent Sio with an accompanying iron unit recovery at 90.5 percent . Iron recoveries from the mill feed ranged from 79.0 to 87.4 percent .

Jan 1, 1964

By Franklin H. Persse

Domestic bismuth supply was projected from production figures for the ores in which it occurs--copper, lead, zinc, and tungsten. Published and unpublished data concerning host ores were examined to determine bismuth reserves and resources, and mine production. Potential recoverable bismuth occurring with reserves and resources of copper, lead, and zinc was estimated to be 36.3 million pounds. A bismuth availability diagram was developed from quantity estimates and ratios of production cost to value for these host ores. Additional recoverable bismuth occurring with domestic tungsten reserves was estimated to be 1.5 million pounds. Domestic byproduct production of bismuth will approximate 1.3 million pounds annually by 1980. This quantity will provide about 37 percent of the 3.5-million-pound estimated requirement for that year. Known world supply of bismuth appears to be sufficient for world demand to the end of this century. The study indicates that bismuth reserves and potential resources in the rest of the world have not been adequately reported.

Jan 1, 1970