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By Vincent Castranova, Jane Y. C. Ma, Joseph K. H. Ma, Chang-geng Mo, Carl J. Malanga

"A group of bisbenzylisoouinoline alkaloids has been shown to exhibit various degrees of effectiveness in preventing silica-induced fibrosis in animal models [1, 2]. The objective the present study was to characterize the binding of several of these alkaloids to phosphatidylcholine vesicles and rat alveolar macrophages using fluorometric and equilibrium dialysis methods, respectively. The lipid binding affinity of these alkaloids was found to depend upon several structural factors including hydrophobic substitutions, chiral configurations, and double oxygen bridge-restricted conformation of the benzylisoquinoline moieties. Tetrandrine, which is a highly effective agent in preventing fibrosis, showed strong binding to both lipid vesicles and alveolar macrophages. In contrast, certain analogues of tetrandrine such as curine and tubocurine, which have little or no effect on silicosis, exhibited only weak binding to lipid vesicles and almost no binding to cells. The moderate binding affinity of fangchinoline to vesicles and cells corresponded to a moderate effectiveness of the compound as an antifibrogenic agent. Methoxyadiantifoline, an alkaloid of unknown antifibrogenic potential, also exhibited high binding affinities for lipid and cells. In conclusion, the results of these studies indicate that alveolar macrophages exhibit large binding capacities for certain members of this class of bisbenzylisoquinoline alkaloids. A positive correlation was observed between binding affinity to alveolar macrophages and the reported antifibrotic potency of these compounds. These data also suggest that the ability of these drugs to interact with alveolar macrophages may be a key step in inhibition of the progression of silica-induced pulmonary disease.INTRODUCTIONInhalation of crystalline silica is associated with the development of silicosis. This fibrotic disease is characterized by the appearance of concentric hyalinized nodular lesions in the lungs with the progressive development of pulmonary dysfunction [3, 4]. Many theories concerning the etiology of silicosis involve silica-induced activation of alveolar macrophages. Evidence indicates that in vitro silica exposures result in the generation of chemiluminescence, and the release of superoxide and hydrogen peroxide from alveolar macrophages [5]. Activation of alveolar macrophages has also been demonstrated after intratracheal instillation or inhalation of silica [5, 6]. Such excess release of reactive products from pulmonary phagocytes has been associated with damage to the lung parenchyma [7, 8]. In addition, silica exposure results in the release of mediators from alveolar macrophages, which enhance proliferation of fibroblasts and collagen synthesis by these pneumocytes [9-12]."

Mar 1, 1992

By E. Dzingayi

Keywords: Pyrometallurgy, furnace, Bindura, nickel The smelter at Bindura Nickel Corporation processes concentrates from its own mines and other external sources. Concentrates are dried, smelted, and converted to a desulphurised matte (leach alloy) for further processing at the refinery. The smelter comprises a drying plant, submerged arc electric furnace, electrostatic precipitator, and three Peirce-Smith type converters capable of treating 150 000 tonnes of concentrates per year. Concentrates are dried in a rotary coal-fired kiln, blended with fluxes, and smelted in a six-in-line submerged-arc 15MW electric furnace. Slag is tapped and granulated for disposal, and matte is tapped at regular intervals for blowing in Peirce-Smith converters. The paper details the 37-year history of the smelter, including furnace rebuilds and operating parameters as they have evolved in response to changing feed compositions. Special challenges, particularly relating to the treatment of high talc concentrates, are also described.

Jan 1, 2006

By A. Mboma

Keywords: Furnace, decommissioning, care and maintenance, re-start, funding, nickel Bindura Nickel Corporation (BNC) operates two nickel mines, and treats concentrates from these mines as well as toll concentrates from the region around its Bindura Smelter and Refinery (BSR) complex. At the smelter, concentrates of at least 5% nickel content are blended and dried to 4% moisture in a coal-fired rotary kiln. Matte smelting of concentrate is carried out in a six-in-line electric arc furnace, where the furnace slag is granulated and discarded. Furnace matte is transferred via ladles into Peirce-Smith converters, where, after granulation, a leach alloy containing 68%Ni, 20%Cu, and 6%S is produced. Converter slag is recycled via the matte-smelting furnace. The onset of the global economic recession towards the end of 2008 resulted in a collapse of metal prices, worsening the local situation that was already marred by unfavourable macro-economic conditions in Zimbabwe. As a result, BNC mines were put on care and maintenance in November 2008, followed by Bindura Smelter and Refinery in February and March 2009 respectively. The business environment has since changed, and BNC is getting ready to re-start the plant. This paper describes the decommissioning of the Bindura furnace, asset preservation during the care and maintenance programme in the past two years, and preparation for starting up of the Bindura smelter in the near future.

Jan 1, 2011

By William I. Busenbark, Elmer C. Newman

At Bingham Canyon, the world's largest open-pit copper mine, annual grease consumption is in the neighborhood of 109 000 kg (240,000 lb), all of which was 544 (120-16) purchased, warehoused, and distributed in 54-kg (120-1b) and 180-kg (400-1b) drums. While perhaps a menial and mundane chore, grease distribution shows on the ledger as a significant expense item. To improve labor and cost performance, Kennecott maintenance engineers undertook a study to find the most direct method for moving multi purpose grease (MPG) from the refinery to the point of final consumption. What they found was a direct vendor system for hulk grease so simple and flexible that long-established drum distribution is being phased out in favor of the newer method throughout 75% of the operation.

Jan 9, 1977

"The greatest mining center in the state of Utah is the incorporated town of Bingham about twenty-five miles southwest of Salt Lake City. The principal industry of this vicinity, prior to the early fall of 1 863, was lumbering and the first saw-mill in the state was built near the mouth of Bingham Canyon. Early in the fall of that year, George B. Ogilvie discovered gold and shortly afterward the first mining district in the state was organized. Some writers place the discovery of gold in the canyon in the late fifties. If this be so, however, the matter was kept extremely quiet because no mining was engaged in until after Ogilvie's discovery.Bingham was a placer mining camp, producing about one million dollars' worth of dust and nuggets from placers up and down the canyon and in Bear Gulch until early in the seventies, or about ten years after the discovery of gold, when a large body of argentiferous lead ore was discovered and soon after heavy shipments were made from a half dozen or more properties.In 1 8 74, A. H. and George L. Bemis erected the first concentrating plant in the state for the treatment of sulphide lead ores.The history of the camp as a producer of copper begins in the summer of 1 88 7, when Enos A. Wall noticed, in observing prospecting drifts and inclines driven some years before, the discoloration caused by the coppery solution. As a large part of the adjacent ground had been abandoned, he located two claims, which he called the ""Dick Mackintosh"" and the ""Charles Reid,"" after two of his friends.Late in 1896, the Highland Boy Mine produced sulphide ore rich in copper, causing a revival of interest in the copper potentialities of the camp, and during the next seven years a number of new claims were located ."

Jan 1, 1925

By R Dwyer

Iron ore currently mined in Australia generally requires very little beneficiation. However, depleting high-grade resources means that in the future low-grade iron ore deposits will need to be mined to meet the increasing demands of the global steel industry. Along with the increased demand, the industry faces additional pressure to reduce the environmental impact of mining and mineral processing. This has stimulated research beyond incremental improvements to conventional processing into alternative low-impact processes, including biotechnological approaches to mineral processing.Bioflotation and bioflocculation have emerged as relatively recent technologies, in which bacteria and/or their extracellular material may be used as flotation reagents (collectors or modifiers), enabling improved selective separation of minerals. The primary advantage is the production of a selective, environmentally-benign alternative to conventional flotation reagents. A biotechnological approach may also be taken in the beneficiation of high-phosphorous iron ores utilising bacteria capable of iron reduction and phosphorous solubilisation.Samples from three iron ore deposits in Western Australia were examined for bacteria suitable for iron ore benefi ciation. A number of common soil microorganisms including Pseudomonas spp, Limnobacter thiooxidans, Paenibacillus spp, and Ralstonia insidiosa were identified using culture-independent molecular techniques. A number of anaerobic species belonging to the genus Clostridium were also identified in the core samples. Selected aerobic species were enriched and isolated on high nutrient media in the presence of haematite. Several of the isolated strains showed an affinity for iron ore, attaching to haematite in enrichment cultures and further demonstrated through adhesion studies. Other isolated species such as Ralstonia isidiosa and Pseudomonas stutzeri are known to solubilise rock phosphates in soils and have potential for the removal of phosphorous from Australian iron ores.

Jul 11, 2011

By Terzis D. PhD, Katterbach M.

While awareness around the environmental impact of existing grout materials and chemical binders is increasing rapidly, biotechnologies are growing traction as sustainable alternatives in groundwork operations. Herein we present the principles and application methods of bio-grouting. The term is used to describe a system which is based on soil, groundwater or marine enzymes which are able to catalyze the production of calcite replicating a natural phenomenon. The system’s end result are mineral crystalline bridges which act as binders to improve the geotechnical properties of soils. This paper presents a comprehensive description of bio-grouts, their underlaying mechanisms contributing to mineralization as well as environmental considerations. With their water-like rheology, bio-grouts have a wide application range and are minimally invasive, requiring only very limited injection pressures. The equipment is the same as that used in conventional cement grouting, and the reactant components are worldwide available or easily suppliable, which explains why bio-grouting has nowadays become a valuable and sustainable alternative towards efficient soil treatment. Recent developments in the last years have allowed to further increase the applicability and efficiency of bio-grouts to ultimately bridge the gap between research and practice. A case study is illustrated in this paper showing the successful implementation of bio-grout for the stabilization of weakly cemented sandstone to safeguard an adjacent road segment in Switzerland

May 1, 2022

By C. Joulian, A. G. Guézennec, A. Chmielarz, Y. Ménard, M. Hanke, P. d’Hugues

"The copper concentrate used in this study is produced by flotation of a black shale organic rich ore. This resource is a carbonate-rich, polymineral concentrate. In the last 5-6 years, ore characteristics changed and the concentrate grades degraded. This study evaluated bioleaching of the concentrate in stirred tank reactors as an alternative to the pyrometallurgical technology that is currently applied, and which may no longer be feasible in future given the concentrate chemistry.The first part of the study focused on testing non-traditional operating conditions during continuous bioleaching experiments: high solids concentration (> 20% solids), reduced agitation and aeration rates. For the same residence time, bioleaching performance at high solids loading (25%) was the same as that reached during previous bioleaching experiments at 15% solids. No mixing or microbial issues were encountered. The bacterial consortium used in the experiments demonstrated a high copper tolerance.The second part of the study was devoted to technology development for metal recovery from copper bearing solutions obtained during bioleaching experiments. Due to the high copper concentration of the leachate, solvent extraction prior to electrowinning was not necessary. After iron removal, high quality copper cathodes (morphology and composition) were obtained from the PLS by electrowinning."

Jan 1, 2014

By A. D. Davis, J. L. Sorensen, C. J. Webb

Environmental impacts from acidic mine drainage are growing national concerns that are particularly acute in the headwaters of the Rocky Mountain region. In the Black Hills of South Dakota, approximately one thousand mines are inactive or abandoned, most of them in the headwaters of major drainages. This paper examines the Bear Butte Creek basin, a heavily mineralized watershed with significant historical mining impacts and a surface gold mine permitted in 1997. The watershed loses its surface discharge to swallow holes in the karstic Madison Limestone. The integrity of the aquatic ecosystem was monitored with a suite of sitespecific bio-indicators. Stream surveys covered the entire reach of Bear Butte Creek from near its headwaters to the swallow holes in the Madison aquifer. Data from the stream surveys, water-quality sampling, and bio-indicator surveys clearly showed that water-quality impacts are limited mainly to Strawberry Creek and to the area of Bear Butte Creek near and downstream of the town of Galena.

Jan 1, 1999

By S. M. Moon

Today, underground exploration is spotlighted as an infinitely developable area. For this purpose, many tunneling technologies were created. And until this very day, many techniques are being developed for more efficient underground movement. Although previous technologies have been developed and now being used in various forms like TMB, struck propulsion method and hydraulic propulsion method, it is hard to find a robot type exploring in small scale. But development of small scale underground exploration robot is a promising research subject for its usage in examination of soil, mineral, and subterranean resources, investigation of hazardous regions, and the military. So we developed a robot that can dig and move underground, inspired from the motion of earthworm and mole cricket. Earthworm and mole cricket dig the soil in the front and draw it off backward, so that they can move forward. We developed a mechanism that uses 2 rotating solid of revolution (bits) for pulverizing the firmly united soil in the front and put it inside the body. The bits rotate in the opposite direction of each other. While moving forward, the soil in the front moves along the spiral on the bit and is saved inside the body. The soil saved inside is taken out through an outlet in the back by a ventilation system. The ventilation system on the ground blows through a hosepipe connected to inner part of the robot and the air blows off the soil. The moving mechanism of exploring underground can be classified into 2 parts. One is to fix the blade link on the soil in a form of 4-bar link. The other one is to move forward rotating the whole link. When the blade link system for movement rotates a certain degree, one blade link is fixed, while the other one is folded in. When 2 blade links of different length rotate as it is, different torque is applied on each link. By the law of action and reaction, the link that has larger torque leads the rotation and movement.

Aug 1, 2013

"Depletion of known ore reserves and increased demand for precious metals have caused a revolution in biohydrometallurgical processing technology for gold recovery. Known ore deposits and future discoveries are most likely to be lower grade sulfide ores that can be difficult to recover with current leaching technology. Future metal recovery operations will increasingly use bio-oxidation techniques.Bacteria are an integral part of mineral cycling and mineral transformation in nature. Although biological processes are recognized as part of the mineralization and oxidation reactions in some ore deposits, they have only recently been applied to enhancing metal recovery in hydrometallurgical procedures. This paper explores the traditional metallurgical application of biological leaching and oxidation reactions and reviews the complete range of bacteria available for metal recovery systems. Pre-treatment of ores with bacteria improves metal recoveries in tank leaching systems and shows promise for heap leaching methods.IntroductionThere is no longer any question that bacteria playa natural role in the on-going transformation of some ore deposits (1,2). As applied to sulfide ores, a few strains have been specifically identified that exhibit a natural leaching potential (3). These bacteria can be isolated from waters and soils in old mining districts where they contribute to continuing leaching and pollution problems in acid drainage and heavy metal solubilization. Sulfur and iron bacteria as well as many heterotrophic strains have also been found in ore deposits and sedimentary rocks at depths up to 2000 meters (4). Their presence in both ore deposits and processed ores shows the microbial association with natural leaching and the potential role that bacteria can play in the development of new leaching technology."

Jan 1, 1988

By Xiu-Xiang Tao

This study investigated bio-liquefaction of lignite and its model compounds of thymol, bezioc acid and quinoline by a fungus, Hypocrea lixii AH. It analyzed, during bio-liquefaction, enzyme activity of oxidase, LiP, Lac, MnP and polyphenol oxidase, and degradation products by UV-Vis, FTIR, 13C NMR and GC-MS. The results showed that the bio-liquefaction percentage (by mass) of lignite was up to 44.86 %. The bio-liquefaction products of lignite were mainly aniline, amide, ether, carboxylic acid ketone and ester. The aromatic ring number was 1-3 with an aromatic carbon ratio of 0.328, which indicated rings opening, bonds breaking and oxidation reaction. By considering with the enzyme activity analysis results, it showed that LiP and Lac catalyzed reactions to open aromatic cycles and to break bonds; esterase to break ester bond; and peroxidase in oxidation reaction.

Aug 1, 2013

Bacteria can play a key role in the processing of 'difficult' ores. Bioleaching opens the way to potentially extract copper from vast amounts of otherwise hard to process refractory low-grade chalcopyrite. In my talk I will outline our research philosophy to develop bioleaching as a Precision Processing unit process step. In our view, Precision Processing is a sophisticated approach to mineral processing where the ultimate goal is to measure and characterise the ore body in-ground and in real time during mining, allowing the down-stream unit processes (bioleaching, in this case) to be continuously tailored and tuned via feedback and feed-forward controls to obtain the highest possible recoveries at the lowest possible cost and environmental impact. I will describe some of the work that we are undertaking to better understand the interfacial phenomena underlying the fundamental bioleaching process with the aim of coming to a Precision Processing approach. We use techniques such as interfacial electrochemistry (scanning electrochemical microscopy, SECM), AFM, zeta potential measurement, and synchrotron science to elucidate the parameters that drive bacterial selectivity and adhesion, bacterial metabolism, and dissolution and precipitation processes for model systems and real chalcopyrite ores. As examples of our research, I will discuss in some detail our method to produce and characterise micro-patterned CuxS - silica thin films as model substrates for electrochemical and bacterial adhesion work and our approach to the interfacial chemical characterisation of extracellular polymeric substances of bio-active bacterial cells. I will also cover some of our recent findings relating to measurement and interpretation of bacterial adhesion on sulfidic substrates and its implications for bacterial adhesion and substrate selectivity. After having identified and discussed crucial leaching parameters, such as pH, Eh, T, [Cu2+], and [O2], the talk will go on addressing some of the early achievements and challenges encountered in our work to design and prepare low-cost, rugged sensing devices that allow the in-situ (in this case, in-dump or in-heap) localised measurement of these parameters. I will conclude my talk by painting the picture of how the work of our group might contribute to realising the dream of transforming bioleaching into genuine high-tech Precision Processing of minerals. This is an ABSTRACT ONLY. A full-length paper was not prepared for this presentation.

Sep 13, 2010

By A I M Ritchie

The pyrite oxidation rate is a process central to both the performance of bio-oxidation heaps, used in the pre-treatment of some refractory gold ores, and to the levels of pollution in acid rock drainage (ARD) from pyritic waste rock dumps. A goal in bio-oxidation heaps is to achieve high oxidation rates in the heap as a whole. In comparison, one way to mitigate the environment impact of ARD, is to reduce the overall oxidation rate in the waste rock dump since pyrite oxidation is the primary pollutant generation process. In both bio-oxidation heaps and waste rock dumps the overall oxidation rate of the pyritic material (the intrinsic oxidation rate) at these sites. Much research has been conducted over the last 40 years or so on the oxidation rate of pyritic material with particular emphasis on the catalytic role played by bacteria. More recently mathematical models and field measurements have clarified the extent to which oxygen transport rates are rate limiting, what the dominant oxygen transport mechanisms are and the physical properties of the heaps which have most impact on these transport rates and on the overall oxidation rate. How the performance of bio-oxidation heaps can be optimised and how the pollution load in drainage from waste rock dumps depends on gas transport mechanisms is briefly reviewed. The sensitive of the overall oxidation rate in bio-oxidation heaps and waste rock dumps to details of the intrinsic oxidation rate is quantified.

Jan 1, 1994

Bio-Oxidation of Arsenic and Stibium Bearing Gold Ores Bio-oxidation of arsenic and stibium bearing gold ores with acidithiobacillus ferrooxidans was studied. The preoxidation results show that the best bio-oxidation technical parameters are the initial pH in the range of 1.8 ~ 2.0, particle sizes under 0.074 mm, temperature in the range of 25¦C ~ 30¦C and rotating speed of the orbital incubator in 100 rpm ~ 160 rpm. The leaching results show that If the ore, of which contain 10.37 per cent arsenic and 36.81 per cent stibium, is not bio-oxidised, gold leaching is only about 41 per cent, after 8 days oxidised, the result is about 76.55 per cent, which improved about 35.62 points. The relationship between gold leaching and arsenic oxidation is direct proportion, furthermore, it needs only partly oxidise and higher gold leaching could be get, for example, gold leaching is over 90 per cent when asenic oxidation is 60 per cent. The results will provide theoretical and technological supports of bio-oxidation arsenopyrite for pretreating refractory gold ores.

Sep 13, 2010

By J. Y. ` Xie

The paper introduced bio-oxidation plants of refractory gold concentrate in China and CCGRI cultures. CCGRI cultures are composed of bacteria and archaea. Archaea Ferroplasma acidiphilum is very thick and fills whole mineral surface. It plays a more dominant role in CCGRI process. Several years of practice has proved that the operating temperature in bioreactors between 38~52?,gold recovery is almost same. Pulp concentration has been increased each year and reached to 25%.

Jan 1, 2014

By M. P. Neira

In-situ leaching of copper from chalcocite relies on ferric iron concentration in the lixiviant being reduced to ferrous. To re-establish the ferric concentration in solution, ferrous must be re-oxidized. This reaction is slow under normal chemical conditions but it is catalyzed by Thiobacillus ferrooxidans bacteria. BHP Copper's Miami In-situ unit developed a bio-reactor as a method of oxidizing ferrous to ferric. The effects on oxidation of temperature, CO2? oxygen, and air injection flowrate were defined. This paper summarizes the results of ferrous bio-oxidation using plastic column packing and oxide ores as bio-reactors and the leaching results of the bio-reacted lixiviant on chalcocite ores.

Jan 1, 1997

By J. K. Afidenyo, J. Osei-Owusu

"The Obuasi Mine of AngloGold Ashanti Limited has been operating the world’s largest Biooxidation Plant at its Sulfide Treatment Plant (STP) in Ghana, using the Gencor Biox® technology since February 1994. The Biox® technology was preferred to other alternative methods of treating refractory sulfide ores such as roasting, pressure oxidation and nitric acid leaching due to among other reasons, its lower capital and operating costs, reduced technical risk, relatively benign environmental impact and its ease of operation and maintenance in a remote location.STP has since commissioning succeeded in operating this technology successfully but not without some operational problems. The Plant has seen a number of upgrades and modifications in its circuits which were motivated by cost, operational and throughput constraints.The objective of this paper is therefore to highlight the mine’s experience in the treatment of its complex carbonaceous refractory sulfide gold ores with emphasis on plant operations and improvements such as the Biox® reactors expansion, flotation concentrate upgrade project and neutralization circuit modifications. The Biox® Plant operating cost is also discussed.INTRODUCTIONThe Obuasi mine forms part of the AngloGold Ashanti Group of Gold Mines. It is located in the Adansi West District of the Republic of Ghana. The mine is primarily an underground operation, although some surface mining still takes place. Ore is processed by two main treatment plants: the Sulfide Treatment Plant (for underground ore) and the Tailings plant (for tailings reclamation operations). A third plant, the Oxide Plant, is used to batch-treat remnant opencast ore and stockpiles, of which there are adequate tonnages to keep the plant operational until 2008.Though reference is made in this paper to the Tailings and Oxide Treatment Plants, the main focus will be on the Sulfide Treatment Plant."

Jan 1, 2008

By F. E. Brinckman, G. J. Olson, D. Johnsonbaugh, T. K. Trout

"Microbiological metal recovery is an emerging technology likely to play an increasing role in commercial ore leaching, metal removal from process and waste streams, and perhaps ultimately in processing to yield metal products in specified forms or oxidation states. We are studying the potential for using microorganisms for the recovery of elements important to emerging materials technologies and for which domestic supplies are limited and/or low grade. Examples to be discussed include the bioaccumulation of yttrium and gallium. These elements are important in the production of new superconductor and semiconductor materials. However, limited domestic reserves and technologies for their recovery may cause supply problems. Microbiological processes may offer new techniques for recovery of these and other strategic elements.IntroductionMicroorganisms in ore leachingMicroorganisms assist in the commercial leaching of copper and uranium from low grade ores (1,2) and recently have been shown to have immediate commercial potential for the pretreatment of refractory gold ores to increase the gold-cyanide recovery yield (3). Copper bioleaching is the best known example of biotechnology applied to metal recovery. Copper can be recovered by commercial leaching of huge piles or dumps of low grade sulfidic ores and waste materials, which are not otherwise processable. Microbial activity in the leach dump environment oxidizes metal sulfides to soluble metal sulfates:"

Jan 1, 1988

By E. Mohammadi Zahrani

In this study, Mg-doped fluorapatite (Mg-FA) nanopowders were prepared through a sol-gel, technique and characterized. Designated degree of Mg2+ ions incorporation into the apatite structure was indicated by the x value in the general formula of (Ca10-xMgx (PO4)6F2), where x=0, 0.25, 0.5, 0.75, and 1. XRD, AAS, FTIR and TEM techniques were utilized to characterize the synthesized nanopowders. In vitro bioactivity of the powders was evaluated in simulated body fluid. Powders had a crystallite size less than 100 nm. It was concluded that Mg-substitution could alter bioactivity and dissolution behaviour of Mg-FA. These two parameters were proportional to magnesium content of the powders.

Jan 1, 2010