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By E. D. Regad, W. E. Wallace, P. S. Mike, C. A. Hill, V. Vallyathan, M. J. Keane

"Respirable-sized quartz, a well-established fibrogenic mineral dust, is compared with kaolin in erythrocyte hemolysis assays aher treatment with saline dispersion of dipalmitoyl phosphatidylcholine, a primary phospholipid component of pulmonary surfactant. Both dusts are rendered inactive after treatment, but the membranolytic activity is partly to fully restored aher treatment with phospholipase Ai. an enzyme normally associated with cellular plasma membranes and lysosomes. Phospholipid-coated dusts were incubated for periods of 2-72 h at a series of applied enzyme concentrations, and the adsorbed lipid species and hemolytic activity were quantitated at each time for both dusts. Surfactant was lost more readily from quartz than from kaolin, with consequent more rapid restoration of mineral surface hemolytic activity for quartz. Interactions of surfactant and mineral surface functional groups responsible for the mineral-specific rate differences, and implications for determining the mineral surface bioavailability of silica and silicate dusts, are discussed. INTRODUCTIONMineral particles depositing in the lung acinus will contact an aqueous coating containing surfactant molecules spread on the air-liquid interface and dispersed within this hypophase; the primary components of that surfactant are diacyl lecithin phospholipids (King and Clements, 1972; King, 1982). Adsorption of this surfactant can suppress the cytotoxicity of mineral dusts (Marks, 1957). Suppression of hemolytic activity, a measure of membranolytic potential and an indicator of bioavailability of the mineral surface, of respirable-sized quartz and kaolin clay dusts with the adsorption of dipalmitoyl glycerophosphorylcholine or dipalmitoyl lecithin (DPL) has been measured (Wallace et al., 1985). Such contact and adsorption of pulmonary surfactant in vivo may provide a first defense system of the lung against respired dusts."

Mar 1, 1992

By Ann Hubbs, Vincent Castranova, Jane Y. C. Ma, De-Hwa Chao, Joseph K. H. Ma

AN OVERVIEW OF THE ACTION OF TETRANDRINE ON SILICOSISBecause of the persistent presence of silica dust in the lungs silicosis is a progressive and irreversible disease. At present, there is no proven effective therapy for silicosis. Limited choices of therapeutic intervention with corticosteroids and other immunosuppressive regimens 1,2 have been accepted for some forms of pulmonary fibrosis. These treatments are only minimally effective, and the results provide little understanding of the disease state due to the lack of correlation between drug activity and the mechanism of fibrosis. Thus, continuing effort must be made in the search for effective antifibrotic agents, which may be used to provide a sequential analysis of the fibrotic process and to open the door for further research and clinical development. Tetrandrine is one of hundreds of drugs screened for antifibrotic activity by Chinese scientists. It has been used in China as a treatment for silicosis in open clinical trials3 and in laboratory animals. The action of tetrandrine on pulmonary fibrosis has been attributed to its ability to inhibit particle stimulation of alveolar macrophages, a key cell type central to the fibrotic process, to release oxygen radicals and inflammatory cytokines. Alveolar macrophages (AM) residing on the alveolar wall, are the predominant phagocytic cells of the lungs responsible for pulmonary defense against inhaled microorganisms and other particles and thus play an important role in maintaining the homeostasis of the lungs. 7 Ample evidence suggests that cells of the monocyte-macrophage series play an important role in the immunopathogenesis of pulmonary fibrosis. When upregulated by silica, alveolar macrophages generate reactive oxygen metabolites8·9 which can damage lung parenchyma and release fibrogenic growth factors and cytokines, 10,11 such as interleukin 1 (IL-1), which can induce fibroblast proliferation and collagen synthesis. The cytokine-mediated fibroblast proliferation and collagen synthesis are key steps in the development and progression of pulmonary fibrosis .11 Previous studies by our group have shown that tetrandrine exhibits strong binding affinity to AM and inhibits particle-stimulated respiratory burst activity (oxygen consumption, superoxide anion release, and hydrogen peroxide secretion) in these cells. 13 In addition, studies by Kang et al. 14 have reported that tetrandrine inhibits silica-induced release of fibrogenic factors such as IL-1 which are capable of inducing fibroblast proliferation and collagen synthesis. Reist et al. 15 further suggested that the antifibrotic action of tetrandrine may be mediated in part by the direct effect of this drug on the ability of fibroblasts to respond to proliferative agents. These results indicate that the mechanism of silicosis involves activation of AM and fibroblasts by silica, resulting in abnormal collagen production due to miscommunications between the cell types. Tetrandrine may interrupt this process by direct interaction with the lung cells.

Jan 1, 1998

By Alan J. Fejes

As part of its mine subsidence research program, the Bureau of Mines and the American Electric Power Co. cooperated on a study, conducted at the Price River Coal Co. No. 3 Mine, directed toward developing the capability to estimate the surface subsidence resulting from longwall mining in a geologic, topographic, and mining environment common to coalfields in the Western United States. Subsidence was monitored at the No. 3 Mine over two adjacent longwall panels. The subsidence study area was reduced when the two planned panels were reduced in length because of equipment failure and a mine fire. Subsidence was measured for 21 months. Subsidence continued for 6 months after mining had been completed. A maximum of 2.2 ft of subsidence occurred over the two longwall panels mined at an overburden depth ranging from 300 to 1,500 ft.

Jan 1, 1986

By W. D. Ludemann, E. A. Loria, E. A. Rowe

The isothermal recrystallization of electrorefined vanadium has been studied as a function of annealing time , temperature , and prior deformation . Specimens were cold- rolled from 30- to 75 - percent reduction in thickness , then annealed from 700 ° to 1,200 ° C at time periods ranging from 1 minute to 96 hours . The course of recrystallization was followed by means of hardness , metallographic , and X- ray techniques , and a recrystallization diagram was constructed . Interpretation of the data indicated that there was around 50- percent softening due to recovery ( first stage of softening) before recrystallization began . The defining of recrystallization limits with respect to the amount of deformation was precisely established for electrorefined vanadium . More than 30- percent reduction was necessary for recrystallization to occur at 850 ° C. With 60- percent reduction , it was initiated at 750 ° C and completed at 950° C. The activation energy for recrystallization , as derived from the data , was 95,300 cal per mole for 60 - percent reduction and annealing at 750 ° to 900 ° C. Recrystallization by the mechanism of nucleation and growth was the principal process during the second stage of softening . minor part of the second stage of softening took place as strain- induced boundary migration , which was observed in specimens reduced 30 percent , bent in L- shape , and annealed at 950 ° C. Grain size decreased significantly only with the largest reductions and annealing between 750 ° and 950 ° C. Grain growth was expressed by the empirical relation D = KKtt"" ,, the exponent being the same at 60- percent reduction and annealing from 750 ° to 900 ° C. Accordingly , the activation energy for grain growth was 75,000 cal per mole .

Jan 1, 1964

By Sidney Katell

This Bureau of Mines study estimates capital investment, operating costs, and selling prices for three underground bituminous mines producing coal with annual production ranging from 1.03 to 3.09 million tons. It is assumed that the mines have a 20-year life. Wages and union welfare payments are considered as of November 12, 1973, under the Bituminous Wage Agreement of 1971, and costs for material and equipment are based on 1973 indexes. Initial capital investment ranges from $12,938,200 for the 1.03-million-ton-per-year (MJ.Vl tpy) mine to $31,435,500 for the 3.09 MM tpy mine. Total capital investment ranges from $21,607,200 to $51,982,000 for the same mines. Corresponding selling prices for the coal range from $9.11 to $8.06 per ton, assuming a 12-percent discounted cash flow rate of return after Federal income taxes.

Jan 1, 1974

By S. Don Brown

Between 1987 and 1988, the Bureau of Mines studied the mineral resources of the White River National Forest and part of the Arapaho National Forest to appraise the resources present and to determine the types of deposits, and their location, that could be mined economically if sufficient demand and metal prices existed. The study included a comprehensive literature search and a limited amount of field investigation of minerals and mining activity in and near the Forest. This report summarizes a more comprehensive minerals report on the Forests prepared by the Bureau of Mines and was written for a general audience without a background in geology or related fields. Mineral resource information indicates that in the Gore Range-the area between Tennessee Pass and Gilman may contain large base-and precious-metal deposits, and could be the focus of exploration activity in the near future. The Breckenridge mining district was found to have a moderate to high likelihood for mineral exploration and possible development of gold. Recent exploration and minor development work has occurred in several other areas: Montezuma, Kokomo-Tenmile, and Upper Blue River districts, and portions of the Sawatch Range.

Jan 1, 1990

By Sam McNary

The U.S. Bureau of Mines used the East Fork Pine Creek watershed to conduct a pilot study for an inactive and abandoned mine lands inventory, during which techniques and methodologies would be developed for subsequent inventories. A total of 177 waste dump samples, 191 mill tailings samples, and 36 stream sediment samples were collected. Water samples were collected from 18 sample sites during five sampling events. Waste dump, tailings, and stream sediment samples were analyzed for antimony, arsenic, cadmium, copper, iron, lead, mercury, and zinc. Results indicate a multidisciplinary approach is necessary: disciplines should include geology, geostatistis, geochemistry, geophysics, biology, hydrology, and remote sensing; small prospects do not generally contribute to watershed contamination, major mine and mill sites may contribute metal enriched sediment of metal enriched water; speciation studies and bioavailability studies are important.

Jan 1, 1995

By Charles L. Parsons, R. B. Moore, S. C. Lind, O. C. SCHAEFER

Early in 1912, from information received by the Bureau of Mines, it became evident that quantities of valuable radium-bearing ore from Colorado were being exported for manufacture in foreign coun- trics and that at least part of the manufactured product was being returned to this country and sold at a price entirely incommensurate with that received by the miner and the prospector. Consequently, in line with its efforts to increase efficiency in the mining and treat- ment of mineral resources, the Bureau of Mines undertook an inves- tigation of conditions. Results of this preliminary investigation were published, in the summer of 1913, as Bulletin 70, which gave an out- line of the radium deposits of the West, the conditions of mining, the wastes involved, and the status of the production of radium from its ores. At about this time newspapers and medical journals were publish- ing statements regarding the value of radium in cancer therapy. These reports, although many of them were exaggerated, brought out clearly the remarkable virtue of the gamma rays for the treat- ment of cancer and other malignant growths. In view of the fact that the largest known supplies of radium ore in the world are in the States of Colorado and Utah and on the public lands of the United States, it was deemed highly important for the Bureau of Mines to study the production of radium in detail. Such study, it was hoped, would enable the prospector and miner to obtain a fairer price for the ores and would furnish information necessary in case Congress appropriated funds to develop methods for extracting radium from ore on the public lands under Government supervision, to be supplied at cost to the hospitals of the Army, Navy, and Public Health Service.

Jan 1, 1915

The Bureau of Mines conducted a field study of respirable dust concentrations at an underground room-and-pillar oil shale mine and at the aboveground milling facility to determine the dust generation sources, personal respirable exposure, characteristic minerals, and size distribution of the dust. Major dust sources in the mine were the scaling and blasthole drilling operations, and major dust sources in the processing mill were the screening and crushing operations. Principal minerals found in the airborne respirable dust were albite, analcite, calcite, dolomite, quartz, and orthoclase. The average alpha-quartz content of mine and mill respirable dust samples was 4.1 pct and 15.5 pct, respectively. Carbonaceous material such as diesel particulate accounted for approximately 75 pct of the respirable particulate found in the mine. The average coefficient of variance of respirable dust concentrations measured with approved personal dust samplers in the mine and mill was 7.6 pct, the best precision observed to date with the personal dust sampler operated in the field.

Jan 1, 1977

By Joseph Grumer

Reported fiscal year 1973 studies of fires and explosions seek to develop capabilities during mining operations to detect and quench ignitions of gas in the face area, to detect and quench by means of passive or triggered barriers explosions propagating in rock-dusted coal dust, and to detect incipient fires early enough for easy extinguishment. Research discussed includes minimum air velocities to lift coal or rock dusts, surveys to determine adequacy of rock dusting, chemical agents to quench gas or coal dust explosions and their relative efficacies, spectra radiated by explosions, and nozzle sprays of extinguishants.

Jan 1, 1973

By Martin S. Oudenhoven

This report describes the results of a Bureau of Mines investigation in which the stress concentrations and distributions caused by inclusions in a strained elastic plate were determined, Finite element analyses were made for 168 models containing single inclusions of elliptical, ovaloidal, and rectangular shape. The variables studied included: horizontal-to-vertical loading ratios, (Sh/Sv) of 0,0.33,0.5, and 1.0; width-to-height ratios (w/h), of 0.25, 0.5, 2, and 4; and Young's modulus of inclusion to Young?s modulus of plate ratios (K ratios) of 0.33, 0.5, 2.0, and 5.0. The results show that the theory for elliptical inclusions can accurately predict the average stress along the x and y axes of symmetry for circular, ovaloidal, and rectangular inclusions from the width-to-height and K ratios. The actual inclusion shape was insignificant, suggesting that the average stresses in other inclusions of irregular shape (orebodies) can be estimated with the theory for an elliptical inclusion. An application of this technique to mining problems is presented. The stresses in the elliptical inclusions were uniform throughout the inclusion for all the models studied.

Jan 1, 1972

By Ludwig Schmidt

Investigations conducted by the Bureau of Dines pertaining to the reduction of evaporation losses of petroleum have shown that such losses may be reduced 70 to 80 per cent by the use of vapor-tight tanks equipped with vacuum and pressure relief valves, and vapor-tight thief hitches. Additional studies have shown that it is often economical to supplement this type of construction with other measures that will reduce evaporation losses still further. Water-cooling systems, insulation, and light colored paints are the measures most often used in connection with vapor-tight tanks. Painting with light colored paints probably is employed in the greater number of cases. On account of the cost of insulation, or of installing water cooling systems, the use of these methods are restricted to tanks containing gasoline or crude petroleum with a very large content of low-boiling fractions. The effect of cooling systems has been discussed in a previous report.2 In choosing paints for tanks many factors must be considered. Probably the three most important are cost, protective value, and color. Many companies have adopted a standard color for all of their tanks in this way they reduce the initial cost of paint by buying in large quantities. The tank farms of such companies usually have a neat appearance, resulting from the uniform painting of all tanks. This procedure also has advertising value. Unfortunately, most of the paints used to protect steel are of the darker colors, usually red or black. These colors accelerate the rate of evaporation. Several companies have solved this difficulty by using a dark colored metal-protective paint as a primer coat, and a paint of any desired color for the final coat. Special metal-protective primers to be used under light-colored cover coats have been placed on the market by several paint manufacturing companies.

Jan 1, 1925

By Michael S. Miller

In 1985 and 1986, at the request of the U.S. Forest Service, the U.S. Bureau of Mines studied the 17,000-acre Pyramid Peak planning area in order to evaluate its identified mineral resources. The planning area is located in Riverside County, CA, 15 miles south of Palm Springs. The planning area contains marginally economic resources of marble and mica, subeconomic resources of garnet and occurrences of gold and tungsten. The area is underlain by marble, quartzite, schist, migmatite, intrusive rock, and a wide zone of intensely sheared rock. Quaternary stream, landslide, talus, and colluvial material overlie the older rocks. Ten claims for marble in or overlapping the southwest and southeast parts of the planning area are current (1986). Many other current claims are outside the planning area, adjacent to or within 2 miles of the southwest and southeast corners. Hundreds of millions of tons of inferred, marginally economic marble in and near the planning area may be mined for cement or lime after other developed resources near markets are depleted or if large-scale construction or other markets develop nearby.

Jan 1, 1987

By Maria I. De Rosa

The major fire and fire injury findings for all metal/nonmetal mining categories for 1990-2001 are shown in tables 64-65. Table 66, partly illustrated in figure 22, shows the number of fires, fire injuries, fire fatalities, risk rates, employees' working hours, and lost workdays for all metal/nonmetal mining categories by time period. For all metal/nonmetal operations (including stone and sand and gravel), a total of 518 fires occurred during 1990-2001; 296 of those fires caused 308 injuries and 4 fatalities (Ewhr = 4,012 x 106 hr, In = 0.015, LWD = 36,204). Thirty fires and 26 injuries involved contractors. The greatest number of fires and fire injuries occurred at surface operations; the highest risk rate values were also calculated for surface operations. The number of fires increased during the first four 2-year time periods (1990-1991, 1992-1993, 1994-1995, and 1996-1997), then decreased during the last two periods (1998-1999 and 2000-2001). The number of injuries showed a decrease throughout the periods, accompanied by an increase in employees' working hours. Twenty-five firefighting interventions by mine rescue teams in underground mines and at least 30 interventions at surface operations were required to combat these fires. However, 45 fires destroyed or heavily damaged facilities and equipment (including 19 pieces of mobile equipment) because of failure of firefighting methods, late fire detection, undetected fires, or fire size. Ninety-seven fires were detected late, and 30 fires were undetected. The ignition sources that caused the greatest number of fires were flame cutting/welding spark/slag/flame (169 fires or 33% with 137 injuries), hydraulic fluid/fuel sprayed onto equipment hot surfaces (89 fires or 17% with 46 injuries and 3 fatalities), heat source/explosion and flammable liquids/ gas/refueling fuel on hot surfaces (98 fires or 19% with 73 injuries), electrical short/arcing (51 fires or 10% with 16 injuries), and spontaneous combustion/hot material (46 fires or 9% with 17 injuries). The flame cutting/welding spark/slag/flame source caused fires usually involving welders' clothing or oxyfuel/grease and other materials (including chute and dust collector liners, flammable liquids, belt material, crusher, hopper and shaker deck materials, washer plants, equipment mechanical components, stampler breaker, hydraulic fluid, rubber tires and hoses, gear boxes, bin feeder, dump rope cables, screen liner and screen panel, kiln and shaft material, pipelines, liquor pumps, wood pallets, electrical junction boxes, handrails, grease, refuse, shop and wood). The spontaneous combustion/hot material and electrical fires were usually detected late due to lack of combustion gas/smoke detection systems. At least 55 of the 89 mobile equipment hydraulic fluid/fuel fires became large fires (requiring 12 mine rescue team interventions in underground

Jan 1, 2004

By Jeffrey H. Welsh

This report presents a study on the use of computerized, continuous remote monitoring systems for fire and explosive atmosphere safety in underground coal mines. The effects of these systems on the safety level in mines are investigated, and the relationship between mine safety regulations and computerized, continuous, remote monitoring is analyzed.

Jan 1, 1982

By T. A. Henrie, J. D. Marchant, E. S. Shedd

Cerium metal was electrowon in a fluoride bath from cerous oxide and tapped from the cell during prolonged operation . Electrolyte constituents were CeF , BaF₂ , and LiF. Twenty- seven pounds of metal of 99.8 percent purity were produced at a rate of 3 pounds per hour and tapped from the cell . Principal impurities were molybdenum , aluminum , oxygen , and carbon . The operating parameters , such as electrode geometry , bath compositions , and oxide feed rate , were investigated . Anode reactions were found to be important factors in cell operation . Stable cerous oxide reacted more uniformly at the anode surface than ceric oxide . Electrowinning was conducted in crucible hearths consisting of both frozen electrolyte and molybdenum metal . Both materials proved satisfactory and did not react with the molten cerium . Stable cerous oxide was prepared by carbothermic reduction and used as a feed material . Cell design proved to be an important factor in continuous cell operation . Complementary to the investigations of electrowinning of cerium , the metal was purified by electrorefining in a chloride electrolyte .

Jan 1, 1964

By Maria I. De Rosa

The U.S. Bureau of Mines performed experiments to determine the embedded hydrogen chloride (HCI) and smoke particle characteristics during combustion of polyvinyl chloride (PVC) and chlorinated mine materials for development of a test parameter. The experiments were conducted in an approximately 20-L furnace at set furnace temperatures of 250° and 1,000° C, for a 14-min duration, with an airflow through the furnace of 10 L/min. The variables studied, as a function of time, were hydrogen chloride embedded on smoke particles, hydrogen chloride concentrations in the gas phase, smoke particle average diameter (dg) and particle concentration (no), and product of smoke particle diameter and concentration (dgno). Other variables included carbon monoxide (CO), carbon dioxide (CO2), and oxygen (O2) concentrations; sample mass weight loss; and furnace temperatures. Results show that there is a correlation between embedded hydrogen chloride, hydrogen chloride gas concentrations, and inverse of the smoke particle diameter-concentration product (1/dgno); the higher the hydrogen chloride gas concentrations, the higher the embedded hydrogen chloride, the higher the 1/(dgno) values. These correlations will enable development of a simple test parameter to assess the toxic hazard that these materials pose during fire.

Jan 1, 2010

By T. H. Dubaniewicz

Fiber-optic technology is progressing rapidly, including the development of fiber-optic sensors for many applications. These sensors have the advantages of high sensitivity, light weight, small size, high bandwidth, and freedom from electromagnetic influences. The U.S. Bureau of Mines is investigating the use of fiber-optic technology to monitor mine atmospheres. This report describes a methane monitor based on differential absorption of infrared light. The monitor can detect methane concentrations as low as 0.2 vol pct as far away as 2 km via fiber-optic cable. The upper range is 100 vol pct methane. Since the system requires no electrical power within the mine, it is intrinsically safe.

Jan 1, 2010

By Floyd D. Everett

The Cougar Spar property is in southwestern Beaver County, Utah, approximately 35 miles by road northwest of Lund, a station on the mainline of the Union Pacific Railroad (fig. 1). Original fluorspar discoveries on the property were made a. short time before 1941. During 1941 lessees produced approximately 600 tons of ores averaging 40 percent CaF2. Bureau of Mines engineers examined the property in 1942 and recommended development. Work was begun in December 1942 and completed in October 1943. The area was mapped by members of the Federal Geological Survey during the project period. Development included surface trenching; drifting, and crosscutting, a short distance below the outcrop. The surface work comprised a total of 440 linear feet of bulldozer and hand trenches. A total of 550 feet of workings was driven on the 100-foot level. Samples were taken for assay from the trench exposures and from the underground workings as work progressed. Pocks in the area of the Cougar Spar property are igneous and consist mainly of fine-grained tuff and quartz monzonite porphyry. The fluorspar mineralization occurs in a northwest fault zone.

Jan 1, 1951

By E. R. Bauer

Noise-induced hearing loss (NIHL) continues to be a concern of the mining industry. A new noise standard (30 CFR, Part 62) is aimed at reducing NIHL in mining through engineering and administrative noise controls. However, the difficulty and expense of implementing engineering controls can make administrative controls an attractive alternative for reducing worker noise exposure. Over the last three years, the National Institute for Occupational Safety and Health (NIOSH) has conducted worker noise exposure surveys in underground and surface coal mines and in coal preparation plants. The surveys revealed numerous possible administrative controls and an approach to implementation and analysis. The surveys have shown that worker dosimetry, time-motion studies and equipment noise profiling are important aspects of effectively utilizing administrative controls. A description of the approach for selecting, implementing and evaluating administrative controls and a list of possible administrative controls are reported.

Jan 1, 2007