Correlation of Lung Crackles with Surface Deformation Using Holographic Interferometry

"INTRODUCTIONThe primary function of the lung, i.e. gas exchange, occurs in peripheral units termed alveoli• Diagnosis of lung dysfunction ls therefore dependent on techniques to evaluate the status of the peripheral airways. Since these airways and alveoli are very small, it is difficult to determine directly how they function or how the function is changing due to disease. Yet this unde1·standing is critical to the design of instrumentation to detect early changes in lung function due to disease.An interesting hypothesis describing one aspect of small airway function has been proposed by Frazer (1) as gas trapping due to the formation of menisci in the airways. An additional study (2) proposes that the breaking and possibly the formation of these menisci could generate lung sounds, i.e. crackles. These lung sounds were recorded by placing a microphone at the trachea of an excised rat lung. The lung was degassed and then inflated and deflated. At points along the path of inflation, lung sounds were recorded. However, determination of the origin of the sounds was not attempted due to the difficulties induced by contacting the lung st1rface with a microphone.The purpose of this paper is to describe a non-contacting, whole field technique to monitor and describe the movements of the lung surface during inflation - deflation cycles.HOLOGRAPHIC INTERFEROMETRYHolographic interferometry is a full field, non-contacting and non-destructive technique that measures deformations of an object with a sensitivity in the order of the wavelength of light. A laser beam is split, with one beam reflected from an object and the other used as a reference beam. Both beams combine to produce a hologram of the object on a photographic plate. The process utilizes the concepts of interference, i.e. the two wave amplitudes will add at the points where the difference in optical path lengths over the exposure period is zero or a whole number of wavelengths and will subtract at other points."