A Report to a Visit to Canada and the United States of America (April-July, 1946) to Enquire into the use of Different Types of Aluminum Powder in the Prevention and Treatment of Silicosis, Together with a General Review of the Subject

Bureau of Medical Inspection, Broken Hill, New South Wales.INTRODUCTIONFor a considerable time it has be3n realised that the pathological changes produced in human lungs by the inhalation of free silica varied, not only according to the amount of silica inhaled, its particle size and the period during which it was inhaled, but also according to other mineral elements which might be admixed with the fine silica dust and inhaled along with it, or inhaled subsequently to the silica containing dust. It was observed that, in many instances, these admixed dusts tended to inhibit the action of the free silica in causing injury to the lungs, as well as the development of certain complications, whilst in other cases it was felt that certain substances could actually accelerate the tissue damage caused by the silica.A fresh impetus to the problem of the prevention of the development of silicosis was given when, in 1937 and 1939, Denny, Robson and Irwin published papers entitled "The Prevention of Silicosis by Metallic Aluminum." Working at the same time at the Saranac La.boratory, and quite independently, and using a colloidal aluminum hydroxide, Gardner arrived at the same conclusions as Denny, Robson and Irwin, namely, that in experimental animals the development of silicotic changes could be prevented if eithertogether with the silica, or subsequent to its inhalation...