Evaluation of Toxicology of Reagents in the Mining Industry

Friedman, Marvin A. Ph.D.
Organization: Society for Mining, Metallurgy & Exploration
Pages: 4
Publication Date: Jan 1, 1994
The following paper describes an overview of evaluations for assessing the potential hazards associated with handling newly developed reagents used in the mining industry. Important factors in determining the risk and hazard associated with handling a particular chemical include hazard identification, dose-response assessment, exposure assessment, and risk characterization. The hazard evaluation step involves collecting and evaluating appropriate toxicology information on a chemical. This can include a comparison of the structure of a developmental chemical with that of a material with known toxicology information. Acute toxicology data, including oral, inhalation, and dermal LD50 values, eye and skin irritation data and sensitization or allergic potential information are typically generated for new chemicals. Environmental and in-vitro genetic toxicology data (e.g. Ames test) are also used to evaluate new mining reagents.
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